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List of works by Michael G. Natchus

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

scientific article

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Analysis of the Potential for N 4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

scientific article published on 27 January 2020

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

scientific article published on 30 January 2013

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

scientific article published on 01 October 2019

Development of a novel progesterone analog in the treatment of traumatic brain injury

scientific article published on 14 September 2018

Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-alpha production

scientific article

Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties

scientific article published on 21 March 2016

Discovery of tetrahydroisoquinoline-based CXCR4 antagonists

scientific article published on 5 September 2013

Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.

scientific article published on 4 June 2016

Host-Directed Inhibitors of Myxoviruses: Synthesis and in Vitro Biochemical Evaluation ⬇️

scientific article published on August 23, 2011

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening

scientific article

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex

scientific article

Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics ⬇️

scientific article published on April 20, 2012

Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer

scientific article published on 25 March 2011

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

scientific article published on 27 July 2018

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase

scientific article published on 13 July 2020

Potent Host-Directed Small-Molecule Inhibitors of Myxovirus RNA-Dependent RNA-Polymerases ⬇️

scientific article published on May 16, 2011

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

scientific article published on 25 December 2019

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

scientific article

Small-Molecule Antiviral β-d--Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Sphingolipid analogues inhibit development of malaria parasites

scientific article

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy

scientific article published on August 2013

The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor

scientific article published in 1997

The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol

scientific article published in 1997

The development of new triazole based inhibitors of tumor necrosis factor-α (TNF-α) production ⬇️

scientific article published on May 19, 2003

The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection

scientific article published on 05 September 2019

Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury

scientific article

β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.

scientific article published on 22 November 2017

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