List of works - Jason M Brenchley

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA

scientific article (publication date: March 2014)

Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys

scientific article

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies

scientific article

Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection

scientific article

Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope

scientific article published on June 2007

Beyond six colors: a new era in flow cytometry

scientific article

CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection

scientific article published on April 2008

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

scientific article published on 14 June 2009

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

scientific article

CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus

scientific article

Commensal-dendritic-cell interaction specifies a unique protective skin immune signature

scientific article

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

scientific article

Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL response

scientific article published in June 2006

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

scientific article

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

scientific article published on 29 July 2008

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

scientific article

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

scientific article

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques

scientific article published on 16 November 2011

Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy

scientific article published on June 2009

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

scientific article

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

scientific article (publication date: April 2003)

Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques

scientific article

Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis

scientific article

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

scientific article published on 11 November 2015

HIV preferentially infects HIV-specific CD4+ T cells

scientific article

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

scientific article (publication date: August 2009)

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome

scientific article published on February 2012

High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance

scientific article published on 03 July 2013

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control

scientific article published on 13 July 2011

Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells

scientific article

Immunodeficiency lentiviral infections in natural and non-natural hosts ⬇️

scientific article published on April 19, 2011

Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy

scientific article

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

scientific article

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

scientific article

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

scientific article

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.

scientific article

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals

scientific article

Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates

scientific article

Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression

scientific article published on 26 June 2011

Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection.

scientific article

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

scientific article

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

scientific article published on 19 November 2006

Microbial translocation, immune activation, and HIV disease

scientific article published on 11 October 2012

Nonprogressive and progressive primate immunodeficiency lentivirus infections

scientific article

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

scientific article

Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome

scientific article

Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction

scientific article

Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques ⬇️

scientific article published on September 18, 2012

Plasma levels of soluble CD14 independently predict mortality in HIV infection

scientific article

Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo

scientific article

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

scientific article published on 16 January 2013

Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques

scientific article published on 11 February 2013

Recombination-Mediated Changes in Coreceptor Usage Confer an Augmented Pathogenic Phenotype in a Nonhuman Primate Model of HIV-1-Induced AIDS ⬇️

scientific article published on August 3, 2011

Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy

scientific article

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

scientific article published on 19 October 2012

Reduction of immune activation with chloroquine therapy during chronic HIV infection

scientific article published on 15 September 2010

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.

scientific article published on 29 September 2011

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage

scientific article

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys

scientific article published on September 2007

Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys

scientific article

Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals

scientific article

Superior T memory stem cell persistence supports long-lived T cell memory

scientific article published on 2 January 2013

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy

scientific article

Th17 cell dynamics in HIV infection

scientific article published on March 2010

The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

scientific article

The mucosal barrier and immune activation in HIV pathogenesis

scientific article

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells

scientific article

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

scientific article

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease

scientific article

Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques

scientific article

List of works by Jason M Brenchley

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA

Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies

Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection

Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope

Beyond six colors: a new era in flow cytometry

CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus

Commensal-dendritic-cell interaction specifies a unique protective skin immune signature

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL response

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques

Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques

Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

HIV preferentially infects HIV-specific CD4+ T cells

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome

High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control

Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells

Immunodeficiency lentiviral infections in natural and non-natural hosts ⬇️

Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals

Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates

Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression

Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection.

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Microbial translocation, immune activation, and HIV disease

Nonprogressive and progressive primate immunodeficiency lentivirus infections

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome

Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction

Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques ⬇️

Plasma levels of soluble CD14 independently predict mortality in HIV infection

Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques

Recombination-Mediated Changes in Coreceptor Usage Confer an Augmented Pathogenic Phenotype in a Nonhuman Primate Model of HIV-1-Induced AIDS ⬇️

Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

Reduction of immune activation with chloroquine therapy during chronic HIV infection

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys

Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys

Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals

Superior T memory stem cell persistence supports long-lived T cell memory

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy

Th17 cell dynamics in HIV infection

The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

The mucosal barrier and immune activation in HIV pathogenesis

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease

Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques