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List of works by Timothy D W Claridge

"Pure by NMR"?

scientific article published on 01 December 2008

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

scientific article published on 2 March 2017

A blood-based metabolomics test to distinguish relapsing-remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application

scientific article published on 24 July 2020

A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.

scientific article published on 9 January 2017

A two-directional approach to enantiopure 1,4-difluoro-cyclohexenes: synthesis of difluorinated cyclitol analogues

scientific article published on 03 September 2008

A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis

scientific article

AC-linked Glycomimetic in the Gas Phase and in Solution: Synthesis and Conformation of the Disaccharide Manα(1,6)-C-ManαOPh

scientific article published on 14 April 2009

All-or-nothing cooperative self-assembly of an annulene sandwich

scientific article

Ammonium-directed dihydroxylation of 3-aminocyclohex-1-enes: development of a metal-free dihydroxylation protocol

scientific article

Ammonium-directed olefinic epoxidation: kinetic and mechanistic insights

scientific article published on 13 August 2012

Amylose-wrapped luminescent conjugated polymers

scientific article published on 01 May 2008

An unsaturated peptidomimetic assembly derived from a carbohydrate

scientific article published in January 2004

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase

scientific article

Anomalous nuclear Overhauser effects in carbon-substituted aziridines: scalar cross-relaxation of the first kind

scientific article published on 28 January 2015

Aromatic and antiaromatic ring currents in a molecular nanoring

scientific article published on 19 December 2016

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

scientific article

Barrierless Photoisomerization of 11-cis Retinal Protonated Schiff Base in Solution

scientific article published on 24 September 2015

Bend ribbon-forming tetrahydrofuran amino acids

scientific article

Binding of (5S)-penicilloic acid to penicillin binding protein 3

scientific article

Biomimetic synthesis of the crispatene core

scientific article published on 01 March 2003

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.

scientific article published on 12 January 2010

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

scientific article

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

scientific article published on 28 April 2016

Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients

scientific article published on March 2015

ChemInform Abstract: Fluoromethylated Derivatives of Carnitine biosynthesis Intermediates - Synthesis and Applications

Classifying the antibody-negative NMO syndromes: Clinical, imaging, and metabolomic modeling

scientific article published on 28 October 2019

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

article

Conformational studies of oligomeric oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose.

scientific article published in September 2005

Cover Picture: Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by19F NMR Spectroscopy (Angew. Chem. Int. Ed. 12/2014)

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

article

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase

scientific article

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

scientific article

Early Diagnosis of Brain Metastases Using a Biofluids-Metabolomics Approach in Mice

scientific article

Endohexosaminidase M: Exploring and Exploiting Enzyme Substrate Specificity

scientific article published on 26 June 2006

Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.

scientific article published in January 2009

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

scientific article

Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.

scientific article published on February 2014

From Disulfide- to Thioether-Linked Glycoproteins

scientific article published on 01 January 2008

Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

Global Aromaticity and Antiaromaticity in Porphyrin Nanoring Anions

Global Aromaticity at the Nanoscale

Group epitope mapping considering relaxation of the ligand (GEM-CRL): including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments

scientific article

Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

scientific article published on 28 April 2016

Helix-forming carbohydrate amino acids

scientific article

Highly (E)-selective Wadsworth-Emmons reactions promoted by methylmagnesium bromide

scientific article published in December 2008

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

scientific article

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

scientific article

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris

scientific article published on 11 February 2007

Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis

scientific article published on 19 April 2021

Interaction of Avibactam with Class B Metallo-β-Lactamases

scientific article

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

scientific article

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis

scientific article

Is JmjC oxygenase catalysis limited to demethylation?

scientific article published on 20 June 2013

Mechanistic Investigation of Rh(I)-Catalyzed Asymmetric Suzuki-Miyaura Coupling with Racemic Allyl Halides

Metal-driven ligand assembly in the synthesis of cyclodextrin [2] and [3]rotaxanes

scientific article published on 05 January 2007

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

scientific article published on 11 September 2017

Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by19F NMR Spectroscopy

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy

scientific article published on 24 February 2014

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde

scientific article published in March 2010

NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis.

scientific article

Nitrogen inversion as a diastereomeric relay in azasugar synthesis: the first synthesis of adenophorine

scientific article published on 01 August 2003

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

scientific article

Normal tissue radioprotection by amifostine via Warburg-type effects

scientific article

Oxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic Acids

scientific article (publication date: 6 October 2014)

Oxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic Acids

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

scientific article

Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis

scientific article published on 01 November 2018

Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites

scientific article published on 08 October 2020

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity.

scientific article published on 22 September 2016

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

scientific article

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.

scientific article published on 3 March 2017

Reducing agent mediated non-enzymatic conversion of  2-oxoglutarate to succinate - implications for oxygenase assays

scientific article published on 01 June 2020

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

scientific article

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

scientific article

Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein

scientific article

Scalar Cross-Relaxation Detected in the NOESY Spectra of Oxazolidines and Thiazolidines.

scientific article published on 11 May 2016

Sequential desymmetrization-fluorination: enantioselective synthesis of fluorinated cyclitols

scientific article published on 01 December 2006

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases

scientific article published on 3 April 2011

Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase

scientific article published on 9 October 2013

Stereospecific anti SE2' fluorination of allenylsilanes: synthesis of enantioenriched propargylic fluorides

scientific article published on 03 April 2008

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

scientific article

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

Structure and reactivity of bicyclic methylene aziridines prepared by intramolecular aziridination of allenes

scientific article published on 18 May 2010

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

scientific article

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

scientific article published on 16 December 2015

Studies on the reaction of glutathione and formaldehyde using NMR.

scientific article published on 24 August 2010

Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles

scientific article published on 28 October 2019

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

scientific article published on 4 November 2014

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor

scientific article

Swarm formation in the desert locust Schistocerca gregaria: isolation and NMR analysis of the primary maternal gregarizing agent

scientific article

Synthesis and characterization of a novel N-F reagent derived from the ethano-Tröger's base: (1)J(FN) coupling constants as a signature for the N-F bond

scientific article published on 11 December 2015

Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

article

Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation

scientific article published in July 2006

Synthesis of fluorophosphate nucleotide analogues and their characterization as tools for ¹⁹F NMR studies.

scientific article published on 08 April 2015

Synthesis, structure and dynamics of methoxynaphthalene-substituted phospha-ruthenocenes and -ferrocenes

scientific article published on 18 May 2005

Synthetic Control of Retinal Photochemistry and Photophysics in Solution

scientific article published on 30 January 2014

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

scientific article published on 12 October 2020

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

scientific article published on 12 July 2017

The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues

scientific article published on 18 January 2011

The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves

scientific article published on 18 July 2015

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

scientific article

The synthesis of oligomers of oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose

scientific article published in June 2005

Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

scientific article published on 01 January 2008

Titelbild: Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by19F NMR Spectroscopy (Angew. Chem. 12/2014)

Torsional and Electronic Factors Control the C-H⋅⋅⋅O Interaction

scientific article (publication date: 7 November 2016)

Tuning the Cavity of Cyclodextrins: Altered Sugar Adaptors in Protein Pores

article by Wen-Wu Li et al published 16 February 2011 in Journal of the American Chemical Society

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

scientific article

Vernier templating and synthesis of a 12-porphyrin nano-ring

scientific article

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

scientific article published on 28 June 2017

α- and α'-Lithiation-Electrophile Trapping of N-Thiopivaloyl and N-tert-Butoxythiocarbonyl α-Substituted Azetidines: Rationalization of the Regiodivergence Using NMR and Computation

scientific article published on 24 September 2015

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

scientific article

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