Search filters

List of works by Michael J Grusby

A Signal Transducer and Activator of Transcription (Stat)4-independent Pathway for the Development of T Helper Type 1 Cells ⬇️

scientific article published on September 21, 1998

Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy

scientific article published on 01 August 1994

Activation of T cells by superantigen in class II-negative mice.

scientific article published on December 1994

An essential role in liver development for transcription factor XBP-1

scientific journal article

Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice

scientific article

Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.

scientific article published on October 1999

B lymphocyte development and activation independent of MHC class II expression

scientific article published on 01 February 1993

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

scientific article published on 01 June 1994

Biology of IL-21 and the IL-21 receptor

scientific article

CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus

scientific article published in May 2001

CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism

scientific article

CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts

scientific article published on 01 April 1997

Casein expression in cytotoxic T lymphocytes

scientific article

Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice

scientific article (publication date: 18 January 1996)

Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease

scientific article

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice

scientific article

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase

scientific article

DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target

scientific article

Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo

scientific article published in April 2004

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc ⬇️

scientific article published on 01 January 1998

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice

scientific article published in September 1991

Development and characterization of IL-21-producing CD4+ T cells

scientific article published on 12 May 2008

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

scientific article

Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

scientific article

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

scientific article

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

scientific article

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands

scientific article

IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis

scientific article

IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet ⬇️

scientific article published on March 11, 2013

IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma

scientific article published in July 2003

IL-21 induces the apoptosis of resting and activated primary B cells

scientific article published on 01 April 2003

IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression

scientific article published in September 2006

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

scientific article published on 01 April 2002

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.

scientific article published on 15 December 2008

Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells

scientific article published on January 1990

Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation

scientific article

Immune responses in MHC class II-deficient mice

scientific article

Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells

scientific article published on 01 February 1997

Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products

scientific article

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

scientific article published on July 1996

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo

scientific article

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

scientific article

Interleukin-21 is required for the development of type 1 diabetes in NOD mice

scientific article published on 10 February 2009

Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL.

scientific article published on 22 May 2002

Marking IL-4-producing cells by knock-in of the IL-4 gene

scientific article published on 01 February 1999

Mice lacking major histocompatibility complex class I and class II molecules

scientific article

Molecular cloning of mouse cathepsin D.

scientific article published on July 1990

Most gamma delta T cells develop normally in the absence of MHC class II molecules

scientific article published on 01 November 1993

NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression

scientific article

NIP45 controls the magnitude of the type 2 T helper cell response.

scientific article

Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells

scientific article published on 01 May 1999

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3 ⬇️

scientific article published on December 6, 2011

PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.

scientific article published on 25 June 2012

PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation

scientific article published on 08 January 2009

PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit

scientific article

Peripheral lymphoid development and function in TCR mutant mice

scientific article published on 01 July 1994

Plasma cell differentiation requires the transcription factor XBP-1

scientific article

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice

scientific article

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity ⬇️

scientific article published on October 14, 1997

Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response

scientific article

Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation ⬇️

scientific article published on 01 November 1997

Regulation of T helper cell differentiation by STAT molecules ⬇️

scientific article published on July 1, 1998

Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.

scientific article published on February 2007

Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development

scientific article

SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling

scientific article published in June 2005

Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

scientific article published on October 1998

Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease

scientific article

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

scientific article published on 01 October 1993

Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression ⬇️

scientific article published on April 1, 1998

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

scientific article

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis

scientific article

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

scientific article published in March 1996

Stat6-dependent and -independent pathways for IL-4 production

scientific article published on 01 December 1999

Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response ⬇️

scientific article published on February 15, 1998

The IL-21 receptor augments Th2 effector function and alternative macrophage activation

scientific article

The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells ⬇️

scientific article published on September 1, 1998

The Zinc Finger Protein ZBTB20 Regulates Transcription of Fructose-1,6-Bisphosphatase 1 and β Cell Function in Mice ⬇️

scientific article published on February 25, 2012

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice

scientific article

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo

scientific article

The transcription factor NF-ATc is essential for cardiac valve formation ⬇️

scientific article published on March 12, 1998

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

scientific journal article

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

scientific article published on November 1993

Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells

scientific article published on 01 June 1999

Transcription of the interleukin 4 gene is regulated by multiple promoter elements

scientific article

Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation

scientific article published on 01 April 1995

Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes

scientific article

Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease

Two levels of help for B cell alloantibody production

scientific article published on February 1996

Upstream elements of the MHC class II E beta gene active in B cells

scientific article

ZBTB20 is required for anterior pituitary development and lactotrope specification

scientific article published on 15 April 2016

Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver

scientific journal article

Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis

scientific article published on 09 March 2009

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

article

Paulina is supported by:

About Paulina

Help