List of works - Robert W Buckheit

"Set it and forget it": women's perceptions and opinions of long-acting topical vaginal gels

scientific article

A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

scientific article

An Algorithm for the Preclinical Development of Anti-HIV Topical Microbicides ⬇️

scientific article published on January 1, 2012

An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.

scientific article published on 4 November 2016

Anti-HSV activity of serpin antithrombin III.

scientific article

Antiviral interactions of combinations of highly potent 2,4(1H,3H)-pyrimidinedione congeners and other anti-HIV agents

scientific article published on 19 October 2011

CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants

scientific article published on 12 December 2013

Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase

scientific article

Current and emerging formulation strategies for the effective transdermal delivery of HIV inhibitors

scientific article

Development of Dual-Acting Pyrimidinediones as Novel and Highly Potent Topical Anti-HIV Microbicides ⬇️

scientific article published on September 6, 2011

Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection ⬇️

scientific article published on January 6, 2012

Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.

scientific article published on 3 March 2008

Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.

scientific article

Development of topical microbicides to prevent the sexual transmission of HIV

scientific article

Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles.

scientific article

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

scientific article published on 6 July 2017

Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1

scientific article

Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles

scientific article

Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes

scientific article

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

scientific article published on 23 January 2015

HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon

scientific article

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice

scientific article published on 03 January 2014

Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

scientific article published on 6 March 2012

Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database

scientific article

In vitro and ex vivo evaluations on transdermal delivery of the HIV inhibitor IQP-0410

scientific article

In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories

scientific article

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef

scientific article

Inhibition of tubulin polymerization by select alkenyldiarylmethanes

scientific article

Inhibitory Potential of Subpopulations of CD8+T Cells in HIV-1-Infected Elite Suppressors ⬇️

scientific article (publication date: December 2012)

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

scientific article

Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp

scientific article

Meaning-making matters in product design: users' sensory perceptions and experience evaluations of long-acting vaginal gels and intravaginal rings

scientific article

Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication

scientific article published on 23 October 2009

Novel targets for HIV therapy

scientific article

Optimization of unique, uncharged thioesters as inhibitors of HIV replication

scientific article

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

scientific article

Potent inhibition of HIV-1 entry by (s4dU)35.

scientific article published in April 2005

Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells

scientific article published on July 2013

Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.

scientific article

Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy ⬇️

scientific article published on December 5, 2011

Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents

scientific article published on August 2006

Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings

scientific article published on 12 December 2011

Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention

scientific article

Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1

scientific article

Susceptibilities of Simian Immunodeficiency Virus to Protease Inhibitors ⬇️

scientific article published on May 1, 2003

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings

scientific article published on April 2006

Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems

scientific article published on 19 June 2007

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on 19 September 2008

Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on September 2005

Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

scientific article

The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets ⬇️

scientific article published on July 10, 2012

The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development

scientific article

The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention.

scientific article published on 17 June 2015

Understanding HIV resistance, fitness, replication capacity and compensation: targeting viral fitness as a therapeutic strategy

scientific article published in August 2004

Vaginal Film Drug Delivery of the Pyrimidinedione IQP-0528 for the Prevention of HIV Infection ⬇️

scientific article published on March 6, 2012

Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1.

scientific article

List of works by Robert W Buckheit

"Set it and forget it": women's perceptions and opinions of long-acting topical vaginal gels

A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

An Algorithm for the Preclinical Development of Anti-HIV Topical Microbicides ⬇️

An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.

Anti-HSV activity of serpin antithrombin III.

Antiviral interactions of combinations of highly potent 2,4(1H,3H)-pyrimidinedione congeners and other anti-HIV agents

CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants

Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase

Current and emerging formulation strategies for the effective transdermal delivery of HIV inhibitors

Development of Dual-Acting Pyrimidinediones as Novel and Highly Potent Topical Anti-HIV Microbicides ⬇️

Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection ⬇️

Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.

Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.

Development of topical microbicides to prevent the sexual transmission of HIV

Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles.

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1

Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles

Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice

Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database

In vitro and ex vivo evaluations on transdermal delivery of the HIV inhibitor IQP-0410

In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef

Inhibition of tubulin polymerization by select alkenyldiarylmethanes

Inhibitory Potential of Subpopulations of CD8+T Cells in HIV-1-Infected Elite Suppressors ⬇️

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp

Meaning-making matters in product design: users' sensory perceptions and experience evaluations of long-acting vaginal gels and intravaginal rings

Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication

Novel targets for HIV therapy

Optimization of unique, uncharged thioesters as inhibitors of HIV replication

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

Potent inhibition of HIV-1 entry by (s4dU)35.

Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells

Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.

Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy ⬇️

Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents

Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings

Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention

Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1

Susceptibilities of Simian Immunodeficiency Virus to Protease Inhibitors ⬇️

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings

Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors

Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets ⬇️

The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development

The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention.

Understanding HIV resistance, fitness, replication capacity and compensation: targeting viral fitness as a therapeutic strategy

Vaginal Film Drug Delivery of the Pyrimidinedione IQP-0528 for the Prevention of HIV Infection ⬇️

Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1.