List of works - Attilio Di Pietro

6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein

scientific article published on 21 May 2012

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

scientific article published in January 2003

A synthetic chalcone as a potent inducer of glutathione biosynthesis

scientific article

A template model for studying anticancer drug efflux transporter inhibitors in vitro

scientific article published on 08 August 2012

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

scientific article

ABCG2 transports and transfers heme to albumin through its large extracellular loop

scientific article

ABCG2: recent discovery of potent and highly selective inhibitors

scientific article published on June 2013

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

scientific article published on 13 February 2007

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents

scientific article

Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.

scientific article

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

scientific article published on 09 January 2009

Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.

scientific article

Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis

scientific article

ChemInform Abstract: The Flavanolignan Silybin and Its Hemisynthetic Derivatives, a Novel Series of Potential Modulators of P-Glycoprotein

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

scientific article

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

scientific article

Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells.

scientific article

Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells

scientific article published on 30 August 2011

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity

scientific article published on March 2017

Highly efficient over-production in E. coli of YvcC, a multidrug-like ATP-binding cassette transporter from Bacillus subtilis.

scientific article published in September 2002

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

scientific article published on 14 October 2013

Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1.

scientific article published on June 2011

Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2).

scientific article

Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity

scientific article published on 02 April 2012

Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

scientific article published on 01 December 2014

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models

scientific article

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

scientific article

MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion.

scientific article published on 18 November 2016

MRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors

scientific article published on 20 January 2011

Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans

scientific article published on 25 July 2018

Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein

scientific article published on 11 November 2011

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells

scientific article

Multidrug resistance ABC transporter structure predictions by homology modeling approaches

scientific article published on March 2011

New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity

scientific article published on 30 September 2013

New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2.

scientific article published on 27 June 2016

Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors

scientific article

Pharmacokinetic interactions in mice between irinotecan and MBL-II-141, an ABCG2 inhibitor.

scientific article published on 16 February 2017

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth

scientific article

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

scientific article published on 3 July 2015

Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.

scientific article

Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953

scientific article published on 01 August 2003

Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach

scientific article

Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.

scientific article published on 6 February 2013

Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position

scientific article

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

scientific article

Recent trends of chalcones potentialities as antiproliferative and antiresistance agents

scientific article published on January 2015

Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2)

scientific article

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

scientific article published on 13 December 2013

Structuring detergents for extracting and stabilizing functional membrane proteins

scientific article

Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein

scientific article published on 06 January 2012

Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones

scientific article published on 24 March 2014

Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance

scientific article

Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2

scientific article published on 12 November 2020

Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein

scientific article

List of works by Attilio Di Pietro

6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

A synthetic chalcone as a potent inducer of glutathione biosynthesis

A template model for studying anticancer drug efflux transporter inhibitors in vitro

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

ABCG2 transports and transfers heme to albumin through its large extracellular loop

ABCG2: recent discovery of potent and highly selective inhibitors

Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.

Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents

Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.

Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis

ChemInform Abstract: The Flavanolignan Silybin and Its Hemisynthetic Derivatives, a Novel Series of Potential Modulators of P-Glycoprotein

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells.

Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity

Highly efficient over-production in E. coli of YvcC, a multidrug-like ATP-binding cassette transporter from Bacillus subtilis.

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1.

Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2).

Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity

Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models

MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts

MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion.

MRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors

Make azoles active again: chalcones as potent reversal agents of transporters-mediated resistance in Candida albicans

Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells

Multidrug resistance ABC transporter structure predictions by homology modeling approaches

New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity

New, highly potent and non-toxic, chromone inhibitors of the human breast cancer resistance protein ABCG2.

Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors

Pharmacokinetic interactions in mice between irinotecan and MBL-II-141, an ABCG2 inhibitor.

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.

Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953

Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach

Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.

Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

Recent trends of chalcones potentialities as antiproliferative and antiresistance agents

Selective Cytotoxicity of 1,3,4-Thiadiazolium Mesoionic Derivatives on Hepatocarcinoma Cells (HepG2)

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

Structuring detergents for extracting and stabilizing functional membrane proteins

Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein

Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones

Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance

Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2

Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein