Search filters

List of works by Marylore Chenel

A physiologically based pharmacokinetic model for strontium exposure in rat.

scientific article

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

scientific article published on 12 November 2019

Application of hematological toxicity modeling in clinical development of abexinostat (S-78454, PCI-24781), a new histone deacetylase inhibitor.

scientific article

Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates.

scientific article

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

scientific article published on 27 March 2018

Development of a complex parent-metabolite joint population pharmacokinetic model.

scientific article published on 27 May 2011

Development of a physiologically-based pharmacokinetic model of the rat central nervous system.

scientific article published on 18 March 2014

Dose ranging pharmacokinetics and brain distribution of norfloxacin using microdialysis in rats

scientific article published in December 2003

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes

scientific article published in December 2008

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

scientific article published on December 2008

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.

scientific article published on 13 January 2018

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

scientific article published on 20 December 2019

Impact of hepatic CYP3A4 ontogeny functions on DDI risk in paediatric PBPK/PD modelling: critical literature review and ivabradine case study

scientific article published on 07 December 2020

Impact of interleukin-6 on drug transporters and permeability in the hCMEC/D3 blood-brain barrier model

scientific article published on 05 August 2020

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes

scientific article published on 21 June 2016

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: a Novel Method to Handle the Interval Censoring Caused by Measurement of Smaller Tumors

scientific article published on 12 January 2016

Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics

scientific article

Influence of the duration of intravenous drug administration on tumor uptake

scientific article published on 25 July 2013

Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART® Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

scientific article published on 20 February 2018

Model Description Language (MDL): A Standard for Modeling and Simulation

scientific article published on 23 June 2017

Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.

scientific article published on 7 March 2018

Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment.

scientific article published on 12 November 2015

Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment

scientific article published on 14 November 2015

Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

scientific article published on 28 October 2021

Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration

scientific article published in January 2006

Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate

scientific article published on November 2003

Optimal blood sampling time windows for parameter estimation using a population approach: design of a phase II clinical trial.

scientific article published in December 2005

Optimal sampling times for a drug and its metabolite using SIMCYP(®) simulations as prior information

scientific article published on January 2013

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm

scientific article

Pharmacokinetic modeling of free amoxicillin concentrations in rat muscle extracellular fluids determined by microdialysis

scientific article

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.

scientific article

Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients

scientific article

Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I.

scientific article

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

scientific article published on 02 April 2019

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

scientific article published on 24 May 2017

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

scientific article published in April 2010

Quantitative Systems Pharmacology approaches for Immuno-oncology: adding virtual patients to the development paradigm

scientific article published on 19 July 2020

Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method

scientific article published on 08 October 2020

Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.

scientific article published on May 2004

Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models

scientific article

Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

scientific article published on 10 November 2019

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

scientific article published on 25 May 2020

Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice

scientific article published on 18 September 2018