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List of works by Marcello Allegretti

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

scientific article published on June 2005

Allosteric Modulation of Chemoattractant Receptors

scientific article

Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls

scientific article published on 20 April 2008

Antinociceptive effect of two novel transient receptor potential melastatin 8 antagonists in acute and chronic pain models in rat.

scientific article published on 27 February 2018

Antitumor Effects of a Human Dimeric Antibody Fragment 131I-AFRA-DFM5.3 in a Mouse Model for Ovarian Cancer ⬇️

scientific article published on November 8, 2011

Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors

scientific article published on 7 August 2011

Autocrine CXCL8-dependent invasiveness triggers modulation of actin cytoskeletal network and cell dynamics

scientific article published on 27 January 2020

Binding Mode Exploration of B1 Receptor Antagonists' by the Use of Molecular Dynamics and Docking Simulation-How Different Target Engagement Can Determine Different Biological Effects

scientific article published on 16 October 2020

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

scientific article published on 06 April 2020

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

scientific article published on 02 October 2020

CXCR1/2 Antagonism Is Protective during Influenza and Post-Influenza Pneumococcal Infection.

scientific article published on 13 December 2017

CXCR1/2 inhibition blocks and reverses type 1 diabetes in mice

scientific article

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

scientific article

CXCR1/2 pathways in paclitaxel-induced neuropathic pain

scientific article

Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs).

scientific article

Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain

scientific article published on 14 June 2019

Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor.

scientific article published on 15 August 2008

Correction to: The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury

scientific article published on 01 August 2019

Correction: Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis

scientific article published on 24 July 2019

Current status of chemokine receptor inhibitors in development ⬇️

scientific article published on April 20, 2012

DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain

scientific article published on 13 August 2019

DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

scientific article published on 16 November 2015

DF3016A induces increased BDNF transcription in ischemic neuroinflammation injury

scientific article published on 05 September 2020

DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats

scientific article published on 6 November 2015

Design of Noncompetitive Interleukin-8 Inhibitors Acting on CXCR1 and CXCR2

scientific article published on 01 August 2007

Development and validation of an LC-MS/MS method for determination of methanesulfonamide in human urine.

scientific article

Development of a systemically-active dual CXCR1/CXCR2 allosteric inhibitor and its efficacy in a model of transient cerebral ischemia in the rat.

scientific article published in March 2006

Differential protein modulation by ketoprofen and ibuprofen underlines different cellular response by gastric epithelium.

scientific article published on 15 July 2017

ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets

scientific article

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study

scientific article published on 03 April 2019

Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise

scientific article published on 30 July 2020

FOCUS ON THE USE OF RESVERATROL AS ADJUVANT IN GLIOBLASTOMA THERAPHY

scientific article published on 31 March 2020

Gastroprotective Effects of L-Lysine Salification of Ketoprofen in Ethanol-Injured Gastric Mucosa

Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice

scientific article

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells

scientific article

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment

scientific article published on 24 January 2017

Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis

scientific article

Multiple anti-tumor effects of Reparixin on thyroid cancer

scientific article

NSAIDs-dependent adaption of the mitochondria-proteasome system in immortalized human cardiomyocytes

scientific article published on 27 October 2020

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

scholarly article

Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis

Phase II Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis

Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury.

scientific article

Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors

scientific article published on 13 June 2009

Synthesis of E-Aryl Ethenesulfonamides: A Simple One-Pot, Two-Step Procedure from 1-Hydroxy-1-arylalkanes ⬇️

scientific article published on October 3, 2003

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling

scientific article published on 26 October 2015

Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

scientific article

The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury

scientific article published on 05 April 2019

Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial

scientific article published on 26 August 2019

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs).

scientific article

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