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List of works by Hiromitsu Kumada

18F-Fluorodeoxyglucose Uptake in Hepatocellular Carcinoma as a Useful Predictor of an Extremely Rapid Response to Lenvatinib

scientific article published on 13 November 2019

A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan

scientific article published on 05 December 2019

A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment who Developed Inclusion Body Myositis.

scientific article published on 30 March 2018

A Pilot Study of Thymosin .ALPHA.1 Therapy for Chronic Hepatitis B Patients

scientific article published on October 1, 2003

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

scientific article published on 21 April 2021

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

scientific article published on 6 April 2009

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region

scientific journal article

A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration

scientific article

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection

scientific article published on 4 June 2015

A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C

scientific article

A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients.

scientific article

A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan: amino acid substitutions in HCV core region as predictor of sustained virological response.

scientific article published on March 2009

A nucleotide sequence variation detection system for the core region of hepatitis C virus-1b

scientific article published on 20 December 2006

A pilot study of triple therapy with telaprevir, peginterferon and ribavirin for elderly patients with genotype 1 chronic hepatitis C.

scientific article published on 16 July 2013

A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C.

scientific article published on 31 January 2009

A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma

scientific article

A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 infection

scientific article published on 22 January 2014

A randomized, controlled study of peginterferon lambda-1a/ribavirin ± daclatasvir for hepatitis C virus genotype 2 or 3.

scientific article published on 19 August 2016

A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.

scientific article published on 18 November 2010

Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C.

scientific article published on 7 October 2010

Accuracy of non-invasive scoring systems for diagnosing non-alcoholic steatohepatitis-related fibrosis: Multicenter validation study

scientific article published on 06 August 2018

Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.

scientific article published in November 2004

Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.

scientific article published in November 2004

Administration of interferon for two or more years decreases early stage hepatocellular carcinoma recurrence rate after radical ablation: A retrospective study of hepatitis C virus-related liver cancer.

scientific article published on 16 September 2010

Advantage of liver stiffness measurement before and after direct-acting antiviral therapy to predict hepatocellular carcinoma and exacerbation of esophageal varices in chronic hepatitis C

scientific article published on 12 January 2020

Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

scientific article

Amino Acid Substitutions in the Hepatitis C Virus Core Region Predict Hepatocarcinogenesis Following Eradication of HCV RNA by All-Oral Direct-Acting Antiviral Regimens.

scientific article published on 10 February 2018

Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment

scientific article published on 8 June 2012

Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy

scientific article published on 5 July 2011

Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.

scientific article published in August 2010

Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy.

scientific article published in June 2011

Amino acid substitutions in the hepatitis C Virus core region and lipid metabolism are associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy.

scientific article published on 16 August 2012

Amino acid substitutions in the hepatitis C virus core region are the important predictor of hepatocarcinogenesis.

scientific article published in November 2007

Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin.

scientific article published in April 2010

Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus.

scientific article published on June 2009

An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads.

scientific article published on 17 April 2009

Analysis of Hepatitis C Virus Genotype 1b Resistance Variants in Japanese Patients Treated with Paritaprevir-Ritonavir and Ombitasvir

scientific article

Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma.

scientific article

Anticarcinogenic impact of interferon on patients with chronic hepatitis C: a large-scale long-term study in a single center

scientific article published in January 2006

Antitumor efficacy of transcatheter arterial chemoembolization with warmed miriplatin in hepatocellular carcinoma

scientific article published on 10 January 2013

Antiviral activity, dose-response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial

scientific article published on 23 May 2009

Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients

scientific article published on 10 May 2011

Association of HLA-DR14 with the treatment response in Japanese patients with autoimmune hepatitis

scientific article published on 22 January 2010

Association of IL28B genotype and viral response of hepatitis C virus genotype 2 to interferon plus ribavirin combination therapy.

scientific article published on October 2012

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy.

scientific article published in November 2005

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy.

scientific article published on 5 May 2009

Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy.

scientific article published in March 2003

Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus.

scientific article published on 23 March 2012

Beneficial effect of arterial embolization with warmed miriplatin for multiple hepatocellular carcinoma

scientific article published on 21 September 2016

Benefit of lamivudine therapy and factors associated with clinical outcome in spontaneous severe acute exacerbation of chronic hepatitis B virus infection

scientific article published in November 2004

Biphasic skin reactions during telaprevir-based therapy of Japanese patients infected with hepatitis C virus

scientific article published in March 2014

Cancer preventive effect of pegylated interferon α-2b plus ribavirin in a real-life clinical setting in Japan: PERFECT interim analysis

scientific article published on June 28, 2011

Change of hepatitis B virus genotypes in acute and chronic infections in Japan

scientific article published in November 2008

Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy

article

Changes in viral loads of lamivudine-resistant mutants during entecavir therapy

scientific article published on 15 June 2007

Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir

scientific article published on 22 November 2012

Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection

scientific article published on 25 September 2017

Circulating MicroRNA-122 and Fibrosis Stage Predict Mortality of Japanese Patients With Histopathologically Confirmed NAFLD

scientific article published on 05 November 2019

Circulating microRNA-122 levels are important predictor of hepatitis B virus surface antigen seroclearance

scientific article published on 10 July 2018

Classification of hepatitis B virus genotypes by the PCR-Invader method with genotype-specific probes

scientific article published on 24 August 2006

Clearance of hepatitis B surface antigen during long-term nucleot(s)ide analog treatment in chronic hepatitis B: results from a nine-year longitudinal study

scientific article published on 12 October 2012

Clinical and pathological characteristics of the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome

scientific article published on 01 June 2004

Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up

scientific article published on February 2005

Clinical and virological effects of long-term (over 5 years) lamivudine therapy

scientific article published in April 2010

Clinical and virological features of non-breakthrough and severe exacerbation due to lamivudine-resistant hepatitis B virus mutants

scientific article

Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.

scientific article published in January 2002

Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study.

scientific article

Clinical effectiveness of bipolar radiofrequency ablation for small liver cancers

scientific article published on October 10, 2012

Clinical features of hepatitis B virus genotype A in Japanese patients.

scientific article published on January 2003

Clinical significance of hepatectomy for primary biliary cirrhosis patients with hepatocellular carcinoma: Report of a single center case series and review of the published work

scientific article published on 07 May 2013

Clinicopathological features, background liver disease, and survival analysis of HCV-positive patients with hepatocellular carcinoma: differences between young and elderly patients

scientific article published on 24 December 2008

Clinicopathological improvement of non-alcoholic steatohepatitis associated with weight loss during a 14-year follow-up period.

scientific article published on 26 September 2007

Clinicopathological indices to predict hepatocellular carcinoma molecular classification

scientific article

Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B.

scientific article published on 22 November 2011

Combination therapy of peginterferon and ribavirin for chronic hepatitis C patients with genotype 1b and low-virus load

scientific article published on 2 March 2009

Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma

scientific article

Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.

scientific article published in June 2011

Comparative quantitative analysis of hepatitis C mutations at amino acids 70 and 91 in the core region by the Q-Invader assay

scientific article published on November 2, 2012

Comparison of interferon and lamivudine treatment in Japanese patients with HBeAg positive chronic hepatitis B

scientific article published on 01 September 2007

Complicated relationships of amino acid substitution in hepatitis C virus core region and IL28B genotype influencing hepatocarcinogenesis

scientific article published on December 2012

Consistently low hepatitis B virus DNA saves patients from hepatocellular carcinogenesis in HBV-related cirrhosis. A nested case-control study using 96 untreated patients

scientific article published in January 2003

Correction to: Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection

scientific article

Correlation between efficacy of daclatasvir/asunaprevir combination therapy and HCV NS3/NS5A resistance-associated variants detected by the PCR-Invader assay

scientific article published in 2015

Correlation between hepatitis B virus surface antigen level and alpha-fetoprotein in patients free of hepatocellular carcinoma or severe hepatitis

scientific article published on 12 October 2013

Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients

scientific article published in January 2009

Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment

scientific article published on 25 September 2009

Corticosteroid withdrawal therapy in patients with chronic hepatitis B virus infection

scientific article published in August 2004

Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter

scientific article published on 02 November 2005

Cross-over study in hyperammonemia patients for efficacy, safety, and acceptability of a new lactulose preparation (SK-1202) compared to approved drug

scientific article published on 09 August 2018

Current issues and management of long-term nucleos(t)ide analogues treatment for chronic hepatitis B

scientific article published in January 2018

Daclatasvir combined with peginterferon alfa-2a and ribavirin in Japanese patients infected with hepatitis C genotype 1.

scientific article published on 22 January 2014

Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection

scientific article

Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection

scientific article published on 9 August 2016

Dermatological side-effects of telaprevir-based triple therapy for chronic hepatitis C in phase III trials in Japan

scientific article published on 5 June 2013

Detection of Hantaviral Antibodies among Patients with Hepatitis of Unknown Etiology in Japan

scientific article published in 2000

Detection of TERT promoter mutation in serum cell-free DNA using wild-type blocking PCR combined with Sanger sequencing in hepatocellular carcinoma

scientific article published on 26 February 2020

Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with HCV genotype 1.

scientific article published on July 2012

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

scientific article published in September 2005

Determinants of the clinical outcome of patients with severe acute exacerbation of chronic hepatitis B virus infection.

scientific article published on 29 February 2012

Development of HCC in patients receiving adefovir dipivoxil for lamivudine-resistant hepatitis B virus mutants.

scientific article published on 25 September 2009

Development of hepatocellular carcinoma in elderly patients with chronic hepatitis C with or without elevated aspartate and alanine aminotransferase levels.

scientific article

Development rate of chronic kidney disease in hepatitis C virus patients with advanced fibrosis after interferon therapy.

scientific article published on 24 August 2011

Diabetes enhances hepatocarcinogenesis in noncirrhotic, interferon-treated hepatitis C patients

scientific article published in October 2010

Diabetes mellitus increases the risk of hepatocarcinogenesis in patients with alcoholic cirrhosis: A preliminary report.

scientific article published on July 2007

Diabetes mellitus worsens the recurrence rate after potentially curative therapy in patients with hepatocellular carcinoma associated with nonviral hepatitis

scientific article published on 17 August 2008

Diagnosis and Resection Treatment of Triplet Hepatocellular Carcinomas with a non-B non-C Background in a Middle Aged Man over a Period of 6-years

scientific article published on 23 June 2020

Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients

scientific article published on 19 December 2011

Differences of hepatocellular carcinoma patients with hepatitis B virus genotypes of Ba, Bj or C in Japan

scientific article published in July 2005

Direct-Acting Antivirals Decreased Tumor Recurrence After Initial Treatment of Hepatitis C Virus-Related Hepatocellular Carcinoma.

scientific article published on 7 September 2017

Discrimination of fibrotic staging of chronic hepatitis C using multiple fibrotic markers

scientific article published on 18 September 2013

Dose Finding of Lenvatinib in Subjects With Advanced Hepatocellular Carcinoma Based on Population Pharmacokinetic and Exposure-Response Analyses

scientific article published on 31 May 2017

Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options

scientific article published on 23 November 2012

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders

scientific article published on 30 January 2012

Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis

scientific article published on February 2006

Early decline of hemoglobin can predict progression of hemolytic anemia during pegylated interferon and ribavirin combination therapy in patients with chronic hepatitis C.

scientific article published on 20 August 2007

Early viral kinetics and treatment outcome in combination of high-dose interferon induction vs. pegylated interferon plus ribavirin for naive patients infected with hepatitis C virus of genotype 1b and high viral load.

scientific article published on January 2005

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

scientific article

Effect of Nuclear Receptor Downregulation on Hepatic Expression of Cytochrome P450 and Transporters in Chronic Hepatitis C in Association with Fibrosis Development

scientific article published on December 13, 2011

Effect of acute self-limited hepatitis C virus (HCV) superinfection on hepatitis B virus (HBV)-related cirrhosis. Virological features of HBV-HCV dual infection

scientific article published on February 2004

Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C.

scientific article published on 7 February 2013

Effectiveness and safety of reduced-dose telaprevir-based triple therapy in chronic hepatitis C patients

scientific article published on 8 January 2014

Effectiveness of Particle Radiotherapy in Various Stages of Hepatocellular Carcinoma: A Pilot Study

scientific article published on 14 March 2018

Effects of Alcohol Consumption on Hepatocarcinogenesis in Japanese Patients With Fatty Liver Disease

scientific article published on 17 December 2015

Effects of a sodium-glucose cotransporter 2 inhibitor in nonalcoholic fatty liver disease complicated by diabetes mellitus: Preliminary prospective study based on serial liver biopsies.

scientific article published on 27 February 2017

Effects of alcohol consumption on multiple hepatocarcinogenesis in patients with fatty liver disease

scientific article published on 16 September 2020

Effects of branched-chain amino acid granules on serum albumin level and prognosis are dependent on treatment adherence in patients with liver cirrhosis

scientific article published on 10 October 2012

Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis

scientific article published on 01 July 2005

Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection

scientific article published on 25 September 2009

Efficacy and Safety of Glecaprevir/Pibrentasvir in Japanese Patients with Chronic Genotype 2 Hepatitis C Virus Infection.

scientific article published on 2 September 2017

Efficacy and Safety of Ramucirumab in Patients with Unresectable Hepatocellular Carcinoma with Progression after Treatment with Lenvatinib

scientific article published on 19 September 2020

Efficacy and anticarcinogenic activity of interferon for hepatitis C virus-related compensated cirrhosis in patients with genotype 1b low viral load or genotype 2.

scientific article

Efficacy and anticarcinogenic activity of ribavirin combination therapy for hepatitis C virus-related compensated cirrhosis

scientific article published on 4 October 2012

Efficacy and resistance of entecavir following 3 years of treatment of Japanese patients with lamivudine-refractory chronic hepatitis B.

scientific article

Efficacy and safety in sitagliptin therapy for diabetes complicated by chronic liver disease caused by hepatitis C virus.

scientific article published on 24 March 2011

Efficacy and safety in sitagliptin therapy for diabetes complicated by non-alcoholic fatty liver disease.

scientific article published on 12 March 2013

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 1b and high virus load

scientific article published in June 2010

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 2 and high virus load

scientific article published in June 2010

Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients.

scientific article published in October 2011

Efficacy and safety of elbasvir plus grazoprevir combination therapy in Japanese patients infected with hepatitis C virus genotype 1b

scientific article published on 23 September 2018

Efficacy and safety of entecavir in lamivudine-refractory patients with chronic hepatitis B: randomized controlled trial in Japanese patients

scientific article published on 28 June 2008

Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection

scientific article published on 20 October 2017

Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis.

scientific article published on 25 September 2017

Efficacy and safety of telaprevir with natural human interferon-β and ribavirin in Japanese chronic hepatitis C patients with depression

scientific article published on 11 May 2017

Efficacy and safety of telaprevir with pegylated interferon α-2a and ribavirin in Japanese patients

scientific article published on 7 April 2016

Efficacy and safety of tenofovir disoproxil fumarate rescue therapy for chronic hepatitis B patients who failed other nucleos(t)ide analogs

scientific article published on 15 November 2016

Efficacy and treatment strategy for drug resistances of nucleos(t)ide analogues for chronic hepatitis B

scientific article published on 01 February 2011

Efficacy in patients with dose reduction in combination therapy of peginterferon and ribavirin for chronic hepatitis C.

scientific article published on 29 February 2008

Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.

scientific article published in October 2004

Efficacy of entecavir treatment for lamivudine-resistant hepatitis B over 3 years: histological improvement or entecavir resistance?

scientific article published on 15 February 2009

Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection.

scientific article published in May 2006

Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors

scientific article published in December 2002

Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy

scientific article

Efficacy of interferon therapy for aged patients with chronic hepatitis C

scientific article published on 01 November 2004

Efficacy of interferon therapy in elderly patients with chronic hepatitis C.

scientific article published in January 2006

Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients

scientific article published on 18 July 2005

Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan.

scientific article published in January 2003

Efficacy of lamivudine therapy in elderly patients with chronic hepatitis B infection

scientific article published on 25 May 2007

Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis

scientific article published in November 2004

Efficacy of long-term tenofovir-based rescue therapy in patients with chronic hepatitis B refractory to nucleoside/nucleotide analogs

scientific article published on 3 October 2016

Efficacy of low-dose intermittent interferon-alpha monotherapy in patients infected with hepatitis C virus genotype 1b who were predicted or failed to respond to pegylated interferon plus ribavirin combination therapy

scientific article published on August 2008

Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus: A randomized, double-blind trial

scientific article

Efficacy of platinum analogue for advanced hepatocellular carcinoma unresponsive to transcatheter arterial chemoembolization with epirubicin

scientific article published on 25 November 2008

Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load

scientific article published in January 2003

Efficacy of reduction therapy of natural human β-interferon and ribavirin in elderly patients with chronic hepatitis C, genotype 1b and high viral load

scientific article published on 21 May 2012

Efficacy of reduction therapy of natural human β-interferon and ribavirin in elderly patients with chronic hepatitis C, genotype 2 and high virus load.

scientific article published on 26 March 2012

Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients.

scientific article published in May 2010

Efficacy of telaprevir-based therapy for difficult-to-treat patients with genotype 2 chronic hepatitis C in Japan

scientific article published on 18 November 2014

Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.

scientific article published on 18 September 2006

Emergence of telaprevir-resistant variants detected by ultra-deep sequencing after triple therapy in patients infected with HCV genotype 1.

scientific article published on June 2013

Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A.

scientific article published in April 2004

Erratum to: Efficacy and resistance of entecavir following 3 years of treatment of Japanese patients with lamivudine-refractory chronic hepatitis B.

scientific article published on 30 October 2010

Estimating the Long-Term Clinical and Economic Outcomes of Daclatasvir Plus Asunaprevir in Difficult-to-Treat Japanese Patients Chronically Infected with Hepatitis C Genotype 1b

scientific article published on 21 May 2014

Estimating the cost-effectiveness of daclatasvir plus asunaprevir in difficult to treat Japanese patients chronically infected with hepatitis C genotype 1b.

scientific article published on 19 August 2015

Evaluation of long-term biochemical responses to combination therapy of interferon plus ribavirin in those infected with hepatitis C virus genotype 1b and high baseline viral load.

scientific article

Evaluation of long-term entecavir treatment in stable chronic hepatitis B patients switched from lamivudine therapy

scientific article

Evolution of hepatitis C virus quasispecies during ribavirin and interferon-alpha-2b combination therapy and interferon-alpha-2b monotherapy

scientific article published on 21 August 2006

Evolution of simeprevir-resistant variants in virological non-responders infected with HCV genotype 1b.

scientific article published on April 2015

Evolution of simeprevir-resistant variants over time by ultra-deep sequencing in HCV genotype 1b.

scientific article published on 5 May 2014

Exploratory study on telaprevir given every 8 h at 500 mg or 750 mg with peginterferon-alpha-2b and ribavirin in hepatitis C patients.

scientific article published on 29 November 2012

Extending combination therapy with peginterferon plus ribavirin for genotype 2 chronic hepatitis C virological responders: a pilot study of 7 cases

scientific article published on 3 March 2010

Factors associated with early cancer-related death after curative hepatectomy for solitary small hepatocellular carcinoma without macroscopic vascular invasion

scientific article

Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.

scientific article

Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C.

scientific article

Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C.

scientific article published on 19 January 2011

Favorable efficacy of daclatasvir plus asunaprevir in treatment of elderly Japanese patients infected with HCV genotype 1b aged 70 and older.

scientific article

Favorable efficacy of glecaprevir plus pibrentasvir as salvage therapy for HCV failures to prior direct-acting antivirals regimens

scientific article published on 03 September 2018

Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study.

scientific article published in April 2005

Fibrosis score consisting of four serum markers successfully predicts pathological fibrotic stages of chronic hepatitis B

scientific article published on 07 November 2012

Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment

scientific article published on 15 June 2020

Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

scientific article

Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C.

scientific article published on 28 January 2012

Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts

scientific article published in January 2008

Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan

scientific article published in January 2010

Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan

scientific article published in January 2010

HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy

scientific article published on 14 September 2010

HBe antigen loss during lamivudine therapy is not caused by mutations in precore and core promoter genes in patients with chronic hepatitis B.

scientific article published in July 2003

HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials

scientific article published on 3 March 2016

HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy

scientific article published on 10 November 2010

HLA-DP genes polymorphisms associate with hepatitis B surface antigen kinetics and seroclearance during nucleot(s)ide analogue therapy.

scientific article published on 28 August 2014

HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study

scientific article

Hepatitis B virus-related hepatocellular carcinogenesis and its prevention

scientific article published in January 2005

Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis

scientific article published on October 2008

Hepatocarcinogenesis following HCV RNA eradication by interferon in chronic hepatitis patients.

scientific article published in October 2008

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

scientific article published on 01 June 2004

Hepatocellular carcinoma is the most common liver-related complication in patients with histopathologically-confirmed NAFLD in Japan

scientific article published on 06 November 2018

Hepatocyte steatosis is an important predictor of response to interferon (IFN) monotherapy in Japanese patients infected with HCV genotype 2a: Virological features of IFN-resistant cases with hepatocyte steatosis

scientific article published on April 2005

Heterogeneous type 4 enhancement of hepatocellular carcinoma on dynamic CT is associated with tumor recurrence after radiofrequency ablation

scientific article published on 01 October 2011

High Sustained Virologic Response to Daclatasvir Plus Asunaprevir in Elderly and Cirrhotic Patients with Hepatitis C Virus Genotype 1b Without Baseline NS5A Polymorphisms

scientific article published on 9 July 2015

High serum des-gamma-carboxy prothrombin level predicts poor prognosis after radiofrequency ablation of hepatocellular carcinoma

scientific article published on 01 February 2009

High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load.

scientific article published on January 2004

Highly sensitive AFP-L3% assay is useful for predicting recurrence of hepatocellular carcinoma after curative treatment pre- and postoperatively.

scientific article

Histological improvements after a three-year lamivudine therapy in patients with chronic hepatitis B in whom YMDD mutants did not or did develop

scientific article published in January 2003

IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.

scientific article published on 12 January 2011

IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C

scientific article published in July 2011

ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.

scientific article published on 14 July 2010

Impact of Mutations at Amino Acid 70 in Hepatitis C Virus (HCV) Genotype 1b Core Region on Hepatocarcinogenesis following Eradication of HCV RNA.

scientific article

Impact of circulating miR-122 for histological features and hepatocellular carcinoma of nonalcoholic fatty liver disease in Japan

scientific article

Impact of daily high-dose IFNalpha-2b plus ribavirin combination therapy on reduction of ALT levels in patients with chronic hepatitis C with genotype 1 and high HCV RNA levels

scientific article published in February 2005

Impact of hepatitis B core-related antigen on the incidence of hepatocellular carcinoma in patients treated with nucleos(t)ide analogues

scientific article published on 20 January 2019

Impact of sodium glucose cotransporter 2 inhibitor on histological features and glucose metabolism of non-alcoholic fatty liver disease complicated by diabetes mellitus

scientific article published on 06 February 2019

Impact of virus clearance for the development of hemorrhagic stroke in chronic hepatitis C.

scientific article published on 24 October 2013

Implication of an extremely high preoperative alpha-fetoprotein value (>4,000 ng/mL) for the long-term outcomes of hepatectomy for resectable hepatocellular carcinoma.

scientific article

In hepatocellular carcinomas, any proportion of poorly differentiated components is associated with poor prognosis after hepatectomy

scientific article published on 01 May 2014

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.

scientific article published in September 2004

Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir.

scientific article published on 18 January 2011

Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b.

scientific article published in January 2010

Influence of hepatitis B virus genotypes on the response to antiviral therapies

scientific article

Influence of hepatitis C virus subtype on hepatocellular carcinogenesis: a multivariate analysis of a retrospective cohort of 593 patients with cirrhosis

scientific article published in January 2002

Inhibition of hepatocellular carcinoma by PegIFNα-2a in patients with chronic hepatitis C: a nationwide multicenter cooperative study

scientific article published on 9 August 2012

Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus

scientific article published on 24 February 2008

Initial- and re-treatment effectiveness of glecaprevir and pibrentasvir for Japanese patients with chronic hepatitis C virus-genotype 1/2/3 infections

scientific article published on 22 March 2019

Integrated Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in Japan

scientific article

Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection

scientific article published on 13 March 2019

Interferon and lamivudine monotherapy on chronic hepatitis B in Japan

scientific article

Interferon for treatment of breakthrough infection with hepatitis B virus mutants developing during long-term lamivudine therapy

scientific article published in January 2002

Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis.

scientific article published in December 2006

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment.

scientific article published on August 2004

Interferon therapy for 2 years or longer reduces the incidence of hepatocarcinogenesis in patients with chronic hepatitis C viral infection.

scientific article published on November 2004

Interferon-alpha for reinfection with hepatitis C virus in two patients with chronic hepatitis C who had responded to previous therapies

scientific article published in August 2003

Interferon-induced prolonged biochemical response reduces hepatocarcinogenesis in hepatitis C virus infection.

scientific article

Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan

scientific article published on 9 January 2014

JSH Consensus Kobe 2009: Diagnosis and Treatment of Hepatitis B

Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B.

scientific article published in March 2005

Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma

scientific article

Ledipasvir plus sofosbuvir as salvage therapy for HCV genotype 1 failures to prior NS5A inhibitors regimens.

scientific article published on 12 January 2017

Lipiodol and dye at the site of ablation decreases during RFA.

scientific article published in January 2008

Liver Fibrosis and Body Mass Index Predict Hepatocarcinogenesis following Eradication of Hepatitis C Virus RNA by Direct-Acting Antivirals.

scientific article published on October 2016

Long-Term Outcomes of Hepatitis-C-Infected Patients Achieving a Sustained Virological Response and Undergoing Radical Treatment for Hepatocellular Carcinoma

scientific article

Long-term clinical remission induced by corticosteroid withdrawal therapy (CSWT) in patients with chronic hepatitis B infection: a prospective randomized controlled trial--CSWT with and without follow-up interferon-alpha therapy

scientific article published in February 2002

Long-term continuous entecavir therapy in nucleos(t)ide-naïve chronic hepatitis B patients

scientific article published on 30 May 2012

Long-term effects of peginterferon alfa-2a therapy in Japanese patients with chronic hepatitis B virus infection.

scientific article

Long-term efficacy and emergence of multidrug resistance in patients with lamivudine-refractory chronic hepatitis B treated by combination therapy with adefovir plus lamivudine

scientific article published on 9 August 2013

Long-term efficacy of interferon therapy in patients with chronic hepatitis B virus infection in Japan.

scientific article published on 24 February 2012

Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection

scientific article published on 6 March 2013

Long-term follow up of peginterferon-α-2a treatment of hepatitis B e-antigen (HBeAg) positive and HBeAg negative chronic hepatitis B patients in phase II and III studies

scientific article published on 15 December 2015

Long-term follow-up of HBeAg-positive young adult Japanese patients treated with corticosteroid withdrawal therapy for chronic hepatitis B

scientific article published on 21 August 2006

Long-term follow-up of clinical trial patients treated for chronic HCV infection with daclatasvir-based regimens

scientific article published on 21 September 2017

Long-term follow-up of interferon monotherapy in 454 consecutive naive patients infected with hepatitis C virus: multi-course interferon therapy may reduce the risk of hepatocellular carcinoma and increase survival

scientific article

Long-term interferon monotherapy reduces the risk of HCV-associated hepatocellular carcinoma

scientific article published on August 2012

Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.

scientific article published in January 2006

Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C.

scientific article published in January 2007

Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase.

scientific article published on November 2006

Long-term outcome of entecavir treatment of nucleos(t)ide analogue-naïve chronic hepatitis B patients in Japan

scientific article published on 22 August 2018

Long-term outcome of hepatocellular carcinoma occurrence, esophageal varices exacerbation, and mortality in hepatitis C virus-related liver cirrhosis after interferon-based therapy

scientific article published on 09 October 2019

Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance.

scientific article published on 26 January 2007

Long-term prognosis by lamivudine monotherapy for severe acute exacerbation in chronic hepatitis B infection: emergence of YMDD motif mutant and risk of breakthrough hepatitis -- an open-cohort study

scientific article published on January 2003

Losartan reduces the onset of type 2 diabetes in hypertensive Japanese patients with chronic hepatitis C.

scientific article published in September 2009

Loss of hepatitis B surface antigen from the serum of patients with chronic hepatitis treated with lamivudine

scientific article published on 01 October 2007

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.

scientific article published in January 2004

Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up

scientific article published in April 2008

Low serum level of hepatitis B core-related antigen indicates unlikely reactivation of hepatitis after cessation of lamivudine therapy

scientific article published on 01 August 2007

Magnetic resonance laparoscopy: A new non-invasive technique for the assessment of chronic viral liver disease

scientific article published on 28 February 2013

Management of hepatitis B: Consensus of the Japan Society of Hepatology 2009.

scientific article published on 11 November 2010

Management of hepatitis C; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009).

scientific article published in April 2010

Minimum resection margin should be based on tumor size in hepatectomy for hepatocellular carcinoma in hepatoviral infection patients

scientific article published on 26 February 2013

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

scientific article published on December 2016

Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan

scientific article published in September 2008

Multivariate analysis of risk factors for the development of type 2 diabetes in nonalcoholic fatty liver disease

scientific article published on 17 June 2009

Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy

scientific article

Natural histories of hepatitis C virus infection in men and women simulated by the Markov model

scientific article published in July 2003

Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections.

scientific article published in April 2006

Natural human interferon beta plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus and a high viral load

scientific article published on 4 November 2008

Necessities of interferon therapy in elderly patients with chronic hepatitis C.

scientific article published on May 2009

New Discriminant Method for Identifying the Aggressive Disease Phenotype of Non-alcoholic Fatty Liver Disease

scientific article published on 15 June 2017

New ablation procedure for a radiofrequency liver tissue coagulation system using an expandable needle.

scientific article published on 12 November 2007

New classification of dynamic computed tomography images predictive of malignant characteristics of hepatocellular carcinoma

scientific article published on 01 October 2010

New discriminant score to predict the fibrotic stage of non-alcoholic steatohepatitis in Japan

scientific article

No-touch ablation in HCC has the potential to prevent intrasubsegmental recurrence to the same degree as surgical resection

scientific article published on 06 November 2018

Non-invasive predictors of prognosis of Asian patients with histopathologically-confirmed lean nonalcoholic fatty liver disease

scientific article published on 04 November 2020

Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studies

scientific article published on 14 March 2014

Origin of neovascular structure in an early stage of hepatocellular carcinoma: study of alpha-smooth muscle actin immunohistochemistry in serial thin sections of surgically resected cancer

scientific article

Outcome of All-Oral Direct-Acting Antiviral Regimens on the Rate of Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Genotype 1-Related Chronic Liver Disease

scientific article

Outline of HCV treatment

scientific article published on February 2015

Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis.

scientific article

PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication

scientific article published on 15 October 2020

Peginterferon alpha-2a (40 KD) plus ribavirin for the treatment of chronic hepatitis C in Japanese patients

scientific article published in May 2007

Peretinoin after curative therapy of hepatitis C-related hepatocellular carcinoma: a randomized double-blind placebo-controlled study

scientific article

Performance of autotaxin as a serum marker for liver fibrosis.

scientific article

Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis

scientific article published on 01 July 2004

Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan

scientific article published on May 2005

Pharmacokinetics of ribavirin in combined interferon-alpha 2b and ribavirin therapy for chronic hepatitis C virus infection

scientific article published in April 2003

Phase 2 study of lenvatinib in patients with advanced hepatocellular carcinoma

scientific article published on 04 October 2016

Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma

scientific article published on 27 July 2020

Pooled analysis of HCV genotype 1 resistance-associated substitutions in NS5A, NS3 and NS5B pre- and post-treatment with 12 weeks of daclatasvir, asunaprevir and beclabuvir

scientific article published on 08 June 2017

Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads

scientific article published on 28 October 2008

Poorly Differentiated Hepatocellular Carcinoma in a Low-risk Patient with an Otherwise Normal Liver

scientific article published on 17 October 2019

Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials

scientific article published on 12 September 2019

Portal vein thrombosis in liver cirrhosis: incidence, management, and outcome.

scientific article published on 25 October 2017

Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection

Potential and Clinical Significance of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Evaluating Liver Cancer Response to Lenvatinib Treatment

scientific article published on 18 November 2020

Potential impact of joint association of alanine aminotransferase and gamma-glutamyltransferase on insulin resistance in Japan: The Toranomon Hospital Health Management Center Study 19 (TOPICS 19).

scientific article published on 21 July 2014

Potential of a no-touch pincer ablation procedure for small hepatocellular carcinoma that uses a multipolar radiofrequency ablation system: An experimental animal study

scientific article published on 07 January 2014

Potential of a no-touch pincer ablation procedure that uses a multipolar radiofrequency ablation system to prevent intrasubsegmental recurrence of small and single hepatocellular carcinomas.

scientific article published on 15 November 2016

Potential of laparoscopy in chronic liver disease with hepatitis B and C viruses

scientific article published on 27 May 2008

Potential of ultra-highly sensitive immunoassays for hepatitis B surface and core-related antigens in patients with or without development of hepatocellular carcinoma after hepatitis B surface antigen seroclearance

scientific article published on 03 December 2020

Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.

scientific article published in January 2003

Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts

scientific article published on 13 March 2006

Prediction of response to pegylated interferon and ribavirin in hepatitis C by polymorphisms in the viral core protein and very early dynamics of viremia.

scientific article published on 29 August 2007

Prediction of treatment efficacy and telaprevir-resistant variants after triple therapy in patients infected with hepatitis C virus genotype 1.

scientific article published on 19 June 2013

Prediction of treatment outcome with daily high-dose IFN alpha-2b plus ribavirin in patients with chronic hepatitis C with genotype 1b and high HCV RNA levels: relationship of baseline viral levels and viral dynamics during and after therapy

scientific article published in October 2004

Predictive factors of advanced recurrence after curative resection of small hepatocellular carcinoma

scientific article published on 27 October 2008

Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: amino acid substitutions in the core region and low-density lipoprotein cholest

scientific article published on 7 November 2006

Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.

scientific article published in January 2006

Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

scientific article published on 19 September 2010

Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study

scientific article published on 11 June 2009

Predictors of Insulin Secretion in Japanese Patients with Histopathologically-confirmed Non-alcoholic Fatty Liver Disease

scientific article published on 18 September 2019

Predictors of pruritus in patients with chronic liver disease and usefulness of nalfurafine hydrochloride

scientific article published on 21 March 2017

Predictors of treatment efficacy and liver stiffness changes following therapy with Sofosbuvir plus Ribavirin in patients infected with HCV genotype 2.

scientific article published on 5 January 2018

Predictors of viral kinetics to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b.

scientific article published in November 2007

Pretreatment Heterogeneous Enhancement Pattern of Hepatocellular Carcinoma May Be a Useful New Predictor of Early Response to Lenvatinib and Overall Prognosis

scientific article published on 04 February 2020

Prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhosis with fasting plasma glucose level of <126 mg/dL.

scientific article published on 11 January 2012

Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b.

scientific article

Prevention of disease progression with anti-inflammatory therapy in patients with HCV-related cirrhosis: a Markov model.

scientific article published on 7 June 2014

Previous chemoembolization response after transcatheter arterial chemoembolization (TACE) can predict the anti-tumor effect of subsequent TACE with miriplatin in patients with recurrent hepatocellular carcinoma.

scientific article published on 27 June 2011

Primary liver carcinoma with sarcomatous changes: Analysis of 10 cases

scientific article published on 08 January 2019

Prognosis and predictors of hepatocellular carcinoma in elderly patients infected with hepatitis B virus.

scientific article published on July 2017

Prolonged hepatitis after acute infection with genotype H hepatitis B virus

scientific article published on 16 November 2007

Prolonged treatment with pegylated interferon alpha 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan

scientific article published on 25 September 2009

Prolonged-efficacy of bisphosphonate in postmenopausal women with osteoporosis and chronic liver disease.

scientific article published in July 2008

Prolonged-interferon therapy reduces hepatocarcinogenesis in aged-patients with chronic hepatitis C.

scientific article published in August 2007

Quantification of collagen and elastic fibers using whole-slide images of liver biopsy specimens.

scientific article published in June 2013

REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset

scientific article published on 12 November 2019

Randomized Controlled Trial Comparing the Efficacy of Impedance Control and Temperature Control of Radiofrequency Interstitial Thermal Ablation for Treating Small Hepatocellular Carcinoma.

scientific article published on 12 March 2015

Randomized Phase 3 Trial of Ombitasvir/Paritaprevir/Ritonavir and Ribavirin for Hepatitis C Virus Genotype 2-Infected Japanese Patients

scientific article published on 23 May 2017

Randomized comparison of daclatasvir + asunaprevir versus telaprevir + peginterferon/ribavirin in Japanese hepatitis C virus patients

scientific article

Randomized controlled trial for the efficacy of hepatic arterial occlusion during radiofrequency ablation for small hepatocellular carcinoma--direct ablative effects and a long-term outcome

scientific article published on 01 April 2007

Randomized controlled trial of a new procedure of radiofrequency ablation using an expandable needle for hepatocellular carcinoma

scientific article published on 02 January 2013

Randomized phase 3 trial of ombitasvir/paritaprevir/ritonavir for hepatitis C virus genotype 1b-infected Japanese patients with or without cirrhosis

scientific article published on 03 July 2015

Randomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients

scientific article published on 23 March 2015

Randomized trial of prolonged interferon retreatment for chronic hepatitis C patients with HCV-genotype 1b and high virus load

scientific article published on April 1, 2003

Randomized, controlled trial of natural interferon-alpha therapy for e-antigen-positive chronic hepatitis B patients

scientific article published in June 2002

Rapid and high sensitive detection of Y93H amino acid substitution in HCV NS5A region using the PCR-Invader assay

scientific article published in 2014

Rapid detection of drug-resistant mutations in hepatitis B virus by the PCR-Invader assay

scientific article published on October 13, 2010

Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), pegylated interferon and ribavirin for 12 weeks.

scientific article published on 10 July 2009

Real-world effects of long-term rifaximin treatment for Japanese patients with hepatic encephalopathy

scientific article published on 09 August 2019

Real-world virological efficacy and safety of daclatasvir/asunaprevir/beclabuvir in patients with chronic hepatitis C virus genotype 1 infection in Japan

scientific article published on 08 March 2019

Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients

scientific article published on January 2003

Recurrence rates of pruritus after the stop of nalfurafine hydrochloride in chronic liver disease: Preliminary prospective confirmatory trial

scientific article published on 24 April 2018

Relationships between Genetic Variations of PNPLA3, TM6SF2 and Histological Features of Nonalcoholic Fatty Liver Disease in Japan

scientific article published on 27 November 2015

Relationships between serum asunaprevir concentration and alanine aminotransferase elevation during daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.

scientific article published on 20 August 2015

Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B

scientific article published on 26 March 2013

Repeated administration of recombinant human serum albumin caused no serious allergic reactions in patients with liver cirrhosis: a multicenter clinical study

scientific article published on 04 July 2008

Reply: To PMID 22991257

scientific article published on 11 October 2013

Reply: To PMID 23213040

scientific article published on 24 March 2014

Resistance Characterization of Hepatitis C Virus Genotype 2 from Japanese Patients Treated with Ombitasvir and Paritaprevir/Ritonavir.

scientific article

Response to long-term lamivudine treatment in patients infected with hepatitis B virus genotypes A, B, and C.

scientific article

Retreatment efficacy and predictors of ledipasvir plus sofosbuvir to HCV genotype 1 in Japan.

scientific article published on 30 June 2016

Role of NS5A-L31/Y93 Double Wild-type in Failure of Glecaprevir/Pibrentasvir Double Therapy in Two Patients with a History of Direct-acting Antiviral Agent Failure: An Ultra-deep Sequencing Analysis

scientific article published on 07 June 2019

SGLT2 Inhibitor Treatment Outcome in Nonalcoholic Fatty Liver Disease Complicated with Diabetes Mellitus: The Long-term Effects on Clinical Features and Liver Histopathology

scientific article published on 23 May 2020

Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection

scientific article published on 17 April 2019

Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H.

scientific article published on 17 April 2007

Serial changes in liver stiffness and controlled attenuation parameter following direct-acting antiviral therapy against hepatitis C virus genotype 1b.

scientific article published on 14 September 2017

Seroclearance rate of hepatitis B surface antigen in 2,112 patients with chronic hepatitis in Japan during long-term follow-up.

scientific article

Serum KL-6 level is elevated in chronic hepatitis C patients with combination therapy of pegylated interferon and ribavirin.

scientific article published on 2 August 2007

Serum levels of gamma-globulin and total bilirubin influence the prevalence of multiple extrahepatic complication in patients with hepatitis C virus infection

scientific article published in January 2003

Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.

scientific article published in May 2004

Side effects of combination therapy of peginterferon and ribavirin for chronic hepatitis-C.

scientific article published on 16 November 2007

Significance of hepatitis B virus DNA clearance and early prediction of hepatocellular carcinogenesis in patients with cirrhosis undergoing interferon therapy: long-term follow up of a pilot study

scientific article published in January 2005

Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis.

scientific article

Significance of oral glucose tolerance tests in non-alcoholic fatty liver disease patients with a fasting plasma glucose level of <126 mg/dL and HbA1c level of ≤ 6.4% in Japan

scientific article published on 15 April 2015

Significance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C.

scientific article published in March 2005

Simeprevir (TMC435) once daily with peginterferon-α-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO-4 study

scientific article published on 29 July 2014

Simeprevir with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1 patients in Japan: CONCERTO-1, a phase III trial

scientific article published on 12 April 2014

Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C.

scientific article

Stage progression of small hepatocellular carcinoma after radical therapy: comparisons of radiofrequency ablation and surgery using the Markov model

scientific article published on 21 February 2011

Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights

scientific article published on 30 June 2020

Stepwise hook extension technique for radiofrequency ablation therapy of hepatocellular carcinoma

scientific article published on 01 January 2002

Strategy for advanced hepatocellular carcinoma unresponsive to transcatheter arterial chemoembolization using epirubicin

scientific article published in March 2010

Substitution of amino acid 70 in the hepatitis C virus core region of genotype 1b is an important predictor of elevated alpha-fetoprotein in patients without hepatocellular carcinoma

scientific article published on August 2008

Successful control of ruptured hepatocellular carcinoma with radiofrequency ablation.

scientific article

Successful direct-acting antiviral treatment of three patients with genotype 2/1 recombinant hepatitis C virus

scientific article published on 16 November 2018

Successful treatment of an entecavir-resistant hepatitis B virus variant

scientific article published in December 2007

Suitable treatment period in patients with virological response during combination therapy of peginterferon and ribavirin for chronic hepatitis C.

scientific article published on 15 July 2008

Survey of survival among patients with hepatitis C virus-related hepatocellular carcinoma treated with peretinoin, an acyclic retinoid, after the completion of a randomized, placebo-controlled trial

scientific article published on 11 September 2014

Sustained negativity for HCV-RNA over 24 or more months by long-term interferon therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load

scientific article published on January 2004

Sustained virologic response by direct antiviral agents reduces the incidence of hepatocellular carcinoma in patients with HCV infection.

scientific article

Sustained virological response in a patient with chronic hepatitis C treated by monotherapy with the NS3-4A protease inhibitor telaprevir

scientific article published on 25 October 2009

Sustained virological response reduces incidence of onset of type 2 diabetes in chronic hepatitis C.

scientific article published on March 2009

TERT Promoter Mutation in Serum Cell-Free DNA Is a Diagnostic Marker of Primary Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease

scientific article published on 30 September 2020

Telaprevir is effective given every 12 h at 750 mg with pegylated interferon-α2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT.

scientific article published on 5 November 2013

Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan

scientific article published on 7 August 2011

The Lack of Hepatocyte Steatosis in Adult-onset Type II Citrullinemia Patients as Assessed by 7-year Interval Paired Biopsies

scientific article published on 25 February 2019

The Patient-Related Burden of Pegylated-Interferon-α Therapy and Adverse Events among Patients with Viral Hepatitis C in Japan

scientific article published on 21 April 2014

The combination of elbasvir and grazoprevir for the treatment of chronic HCV infection in Japanese patients: a randomized phase II/III study

scientific article

The complex association of virus- and host-related factors with HCC rate following HCV clearance

scientific article published on 02 January 2019

The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease.

scientific article published in May 2011

The efficacy and safety of dual oral therapy with daclatasvir and asunaprevir for genotype 1b in Japanese real-life settings

scientific article published on 8 February 2017

The efficacy of 24-week interferon monotherapy for type C liver cirrhosis in Japanese patients with genotype 1b and low virus load

scientific article published on 7 October 2008

The efficacy of interferon-beta monotherapy for elderly patients with type C hepatitis of genotype 2.

scientific article published on 17 August 2009

The efficacy of short-term interferon-beta therapy for chronic hepatitis C patients with low virus load

scientific article published on 3 March 2008

The efficacy of short-term interferon-beta therapy for type C cirrhotic patients with genotype 2a and low virus load.

scientific article published on 16 June 2008

The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.

scientific article published on March 2003

The influence of histological differentiation grade on the outcome of liver resection for hepatocellular carcinomas 2 cm or smaller in size

scientific article published in May 2015

The safety and efficacy of elbasvir and grazoprevir in participants with hepatitis C virus genotype 1b infection

scientific article published on 17 January 2018

Therapeutic effects of short- and intermediate-term tolvaptan administration for refractory ascites in patients with advanced liver cirrhosis

scientific article published on 27 November 2014

Therapeutic strategies for hepatitis C

scientific article published in July 2004

Three-Dimensional Imaging Using Contrast-Enhanced and Three-Dimensional Ultrasound Techniques in the Ablative Zone Treated with a Multipolar Radiofrequency Ablation System for Hepatocellular Carcinoma.

scientific article published on 17 March 2016

Three-dimensional magnetic resonance imaging for stringent diagnosis of advanced fibrosis associated with nonalcoholic steatohepatitis.

scientific article published on 30 January 2013

Timing of interferon therapy and sources of infection in patients with acute hepatitis C

scientific article published on 15 December 2005

Transarterial chemoembolization with miriplatin vs. epirubicin for unresectable hepatocellular carcinoma: a phase III randomized trial

scientific article published in August 2017

Transcatheter arterial chemotherapy using miriplatin-lipiodol suspension with or without embolization for unresectable hepatocellular carcinoma.

scientific article published on 30 December 2011

Transcatheter arterial chemotherapy with miriplatin for hepatocellular carcinoma patients with chronic renal failure: report of three cases

scientific article published on 14 March 2013

Transcatheter arterial chemotherapy with miriplatin for patients with hepatocellular carcinoma and chronic renal failure

scientific article published on November 1, 2011

Treatment strategy for chronic hepatitis B in Japan

scientific article published on 01 May 2011

Treatment strategy for chronic hepatitis C in Japan

scientific article published on May 1, 2011

Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B.

scientific article published on 9 December 2008

Two subtypes of genotype B (Ba and Bj) of hepatitis B virus in Japan

scientific article published on 9 April 2004

Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy

scientific article published in January 2003

Undifferentiated carcinoma of the liver demonstrated by contrast-enhanced ultrasonography

scientific article published on 10 July 2020

Usefulness and limitations of balloon-occluded transcatheter arterial chemoembolization using miriplatin for patients with four or fewer hepatocellular carcinoma nodules

scientific article published on 12 July 2016

Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus.

scientific article published on October 2003

Usefulness of the serum KL-6 assay in patients with hepatitis C virus

scientific article

Utility of detection of telaprevir-resistant variants for prediction of efficacy of treatment of hepatitis C virus genotype 1 infection

scientific article

Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 (GT1b) infection: Phase 3 studies

scientific article published on 02 March 2016

Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study

scientific article published on 25 September 2015

Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers

scientific journal article

Viral dynamics and pharmacokinetics in combined interferon alfa-2b and ribavirin therapy for patients infected with hepatitis C virus of genotype 1b and high pretreatment viral load

scientific article published in January 2002

Viral elimination reduces incidence of malignant lymphoma in patients with hepatitis C.

scientific article published in December 2007

Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in Japan

scientific article published in December 2002

Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir

scientific article

Virological and biochemical features in elderly HCV patients with hepatocellular carcinoma: amino acid substitutions in HCV core region as predictor of mortality after first treatment.

scientific article published on 17 June 2009

Virological and biochemical relapse according to YMDD motif mutant type during long‐term lamivudine monotherapy

scientific article published on December 1, 2003

Virological and biochemical relapse after discontinuation of lamivudine monotherapy for chronic hepatitis B in Japan: comparison with breakthrough hepatitis during long-term treatment

scientific article published in March 2005

Virological differences between patients infected with subtypes Ba and Bj of hepatitis B virus genotype B.

scientific article published in April 2005

Virological escape in HCV genotype-1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b

scientific article published on 22 January 2014

Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C.

scientific article

Virological response and hepatocarcinogenesis in lamivudine-resistant hepatitis B virus genotype C patients treated with lamivudine plus adefovir dipivoxil.

scientific article

Virological response in patients with hepatitis C virus genotype 1b and a high viral load: impact of peginterferon-alpha-2a plus ribavirin dose reductions and host-related factors

scientific article published in January 2008

Virus clearance reduces bone fracture in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus.

scientific article published in March 2010

What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study

scientific article published on 14 August 2013

YMDD mutants in patients with chronic hepatitis B before treatment are not selected by lamivudine

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