List of works - Cynthia Tallant

A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins

scientific article

Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.

scientific article

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

scientific article published on 27 December 2018

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

BET inhibition as a new strategy for the treatment of gastric cancer

scientific article

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

scientific article

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

scientific article

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

scientific article

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

scientific article published in 2015

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

scientific article published on 9 January 2017

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.

scientific article published on 17 July 2017

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.

scientific article

Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors

scientific article

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

scientific article published on 23 March 2015

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

scientific article

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

scientific article (publication date: 2 July 2014)

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

scientific article published on 14 May 2015

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability

scientific article

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

scientific article published on 4 November 2017

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

scientific article published on 27 April 2016

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

scientific article published on 13 March 2015

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

scientific article

Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.

scientific article published on 26 March 2018

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

scientific article

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

scientific article (publication date: 18 May 2015)

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

scientific article

Matrix metalloproteinases: fold and function of their catalytic domains

scientific article (publication date: 2010)

Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases

scientific article

Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.

scientific article published on 18 December 2014

New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.

scientific article published on 14 September 2015

On the Relevance of the Met-turn Methionine in Metzincins

scientific article

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

scientific article published on 12 October 2016

Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation

scientific article published on 29 August 2017

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

scientific article published on 13 November 2015

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

scientific article published on 26 February 2015

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

scientific article

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

scientific article

Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex

scientific article published in January 2007

Unique Structure and Stability of HmuY, a Novel Heme-Binding Protein of Porphyromonas gingivalis

scientific article

List of works by Cynthia Tallant

A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins

Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

BET inhibition as a new strategy for the treatment of gastric cancer

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.

Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

Matrix metalloproteinases: fold and function of their catalytic domains

Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases

Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.

New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.

On the Relevance of the Met-turn Methionine in Metzincins

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex

Unique Structure and Stability of HmuY, a Novel Heme-Binding Protein of Porphyromonas gingivalis