List of works by Philip Efron

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1543

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

scientific article

A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis

scientific article published on 16 August 2021

A Review of GM-CSF Therapy in Sepsis

scientific article

A better understanding of why murine models of trauma do not recapitulate the human syndrome

scientific article

A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma

scientific article

A pilot study on the randomization of inferior vena cava filter placement for venous thromboembolism prophylaxis in high-risk trauma patients.

scientific article published in August 2011

A protocol for non-operative management of uncomplicated appendicitis

scientific article published in February 2018

A regionalised strategy for improving motor vehicle-related highway driver deaths using a weighted averages method

scientific article

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma

scientific article published on 15 December 2020

Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes

scientific article published on 25 July 2020

Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.

scientific article published in July 2017

Acute kidney injury is associated with early cytokine changes after trauma

scientific article published on April 2013

Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing

scientific article

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

scientific article

Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis

scientific article published on 05 July 2019

Aged mice are unable to mount an effective myeloid response to sepsis

scientific article published on 13 December 2013

Aluminum Adjuvant Improves Survival via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis

scientific article published on 04 August 2020

Analysis of factorial time-course microarrays with application to a clinical study of burn injury

scientific article

Anemia and blood transfusion in elderly trauma patients

scientific article published on 01 September 2018

Artificial Intelligence and Surgical Decision-Making

scientific article published on 11 December 2019

Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study

scientific article published on 23 November 2020

B cells enhance early innate immune responses during bacterial sepsis

scientific article

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

scientific article published on 14 December 2017

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.

scientific article published in May 2012

Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned

scientific article published on 01 August 2003

CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis

scientific article published in September 2005

Candida albicans necrotizing soft tissue infection: a case report and literature review of fungal necrotizing soft tissue infections

scientific article published on June 2013

Cecal Slurry Injection in Neonatal and Adult Mice

scientific article published on 01 January 2021

Cecal ligation and puncture.

scientific article

Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma

scientific article published on 20 September 2019

Characterization of erythropoietin and hepcidin in the regulation of persistent injury-associated anemia

scientific article published on 8 July 2016

Characterization of hypoalbuminemia following temporary abdominal closure.

scientific article published on 23 August 2017

Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis

scientific article published in September 2004

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome

scientific article published on 02 July 2018

Chronic stress induces persistent low-grade inflammation

scientific article published on 30 July 2019

Clinical Impact of a Dedicated Trauma Hybrid Operating Room

scientific article published on 20 November 2020

Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study

scientific article published on 13 November 2020

Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress

scientific article published on 11 October 2016

Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma

scientific article published on 23 June 2017

Clostridium difficile Infections after Blunt Trauma: A Different Patient Population?

scientific article published on 2 June 2015

Computed tomography evidence of fluid in the hernia sac predicts surgical site infection following mesh repair of acutely incarcerated ventral and groin hernias

scientific article published on 20 April 2017

Computer versus paper system for recognition and management of sepsis in surgical intensive care

scientific article published in February 2014

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F Osuchowski et al published October 2018 in Infection

Cost and Mortality Associated With Postoperative Acute Kidney Injury.

scientific article

Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.

scientific article

Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes

scientific article published on 01 September 2019

Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response

scientific article published on March 2004

DISTINCT IMMUNOLOGIC ENDOTYPES ARE ASSOCIATED WITH CLINICAL TRAJECTORY AFTER SEVERE BLUNT TRAUMA AND HEMORRHAGIC SHOCK

scientific article published on 17 November 2020

Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress

scientific article published on 17 January 2017

Decision analysis and reinforcement learning in surgical decision-making

scientific article published on 13 June 2020

Delayed emergency myelopoiesis following polymicrobial sepsis in neonates

scientific article

Delayed interhospital transfer of critically ill patients with surgical sepsis

scientific article published on 01 January 2020

Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock.

scientific article

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients

scientific article published on May 2013

Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-α

Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress

scientific article published on 06 March 2006

Discovery and Validation of Urinary Molecular Signature of Early Sepsis

scientific article published on 25 September 2020

Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma.

scientific article published on 12 February 2017

Editorial: Myeloid-derived suppressor cells: a new therapeutic target in sepsis patients

scientific article published on 01 August 2017

Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress

scientific article published on 28 October 2019

Effect of Time to Operation on Value of Care in Acute Care Surgery

scientific article published on 19 January 2018

Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor.

scientific article published on 2 November 2016

Emergent laparotomy and temporary abdominal closure for the cirrhotic patient

scientific article

Enteral Nutrition Administration Record (ENAR) Prescribing Process Using Computerized Order Entry: A New Paradigm and Opportunities to Improve Outcomes in the Critically Ill

scientific article published on 08 May 2020

Evidence for Persistent Immune Suppression in Patients WHO Develop Chronic Critical Illness After Sepsis

scientific article published on 6 September 2017

Excessive nitric oxide impairs wound collagen accumulation

scientific article published on 26 December 2012

Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions

scientific article published on 20 July 2005

Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.

scientific article published in June 2005

Geriatric traumatic brain injury—What we know and what we donʼt

scientific article published on 01 October 2018

Gram stain can be used to safely discontinue vancomycin therapy for early pneumonia in the trauma intensive care unit

scientific article

Host responses to sepsis vary in different low-lethality murine models

scientific article

Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock

scientific article

Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure

scientific article published on 14 November 2017

Identification and description of a novel murine model for polytrauma and shock

scientific article published on April 2013

Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults

scientific article published on 24 June 2020

Impact of Injury Severity on the Inflammatory State and Severe Anemia

scientific article published on 24 December 2019

Improbable survival after prolonged traumatic cardiopulmonary arrest: revisiting the 15-minute rule

scientific article published in June 2013

Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation

scientific article published on June 2015

Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol

scientific article published on 25 October 2016

Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates

scientific article published on 21 December 2016

Increased lymphoid tissue apoptosis in baboons with bacteremic shock

scientific article published in June 2004

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

scientific article

Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis

scientific article published on 30 January 2022

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.

scientific article published on 4 April 2018

Integrating "big data" into surgical practice.

scientific article

Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning

scientific article published on 23 August 2006

Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?

scientific article published on 11 May 2013

Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes

scientific article published on 22 April 2009

Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA.

scientific article published on 22 September 2006

Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma

scientific article published on 26 December 2020

Microbial recognition and danger signals in sepsis and trauma

scientific article published on 20 January 2017

Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis

scientific article

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage

scientific article published on 19 September 2011

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F. Osuchowski et al published 14 August 2018 in Infection

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Modulation of the HGF/c-Met axis impacts prolonged hematopoietic progenitor mobilization following trauma and chronic stress

scientific article published on 03 January 2020

Mopeds and scooters: crash outcomes in a high traffic state

scientific article

Mortality and Cost of Acute and Chronic Kidney Disease after Vascular Surgery

scientific article

Mouse Injury Model of Polytrauma and Shock.

scientific article published in January 2018

Murine Models of Sepsis and Trauma: Can We Bridge the Gap?

scientific article

MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery

scientific article published on 27 February 2018

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis

scientific article published on 13 November 2019

National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury

scientific article

Neural network prediction of severe lower intestinal bleeding and the need for surgical intervention.

scientific article published on 30 December 2016

Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling

scientific article

Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia

scientific article

Obese patients show a depressed cytokine profile following severe blunt injury.

scientific article published on March 2012

Occult bowel injury after blunt abdominal trauma

scientific article published on 28 November 2018

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model

scientific article published on 01 November 2019

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival

scientific article published on 15 April 2020

Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints

scientific article published on 01 January 2019

Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis

scientific article published on 17 November 2015

Persistent inflammation and anemia among critically ill septic patients

scientific article published on 01 February 2019

Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care

scientific article published on June 2012

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery

scientific article published on 26 May 2018

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma

scientific article

Persistent injury-associated anemia and aging: Novel insights.

scientific article published in March 2018

Persistent injury-associated anemia in aged rats.

scientific article published on 4 January 2018

Persistent injury-associated anemia: the role of the bone marrow microenvironment

scientific article published on 31 March 2017

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes

scientific article published on 13 April 2019

Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness

scientific article published on 31 December 2019

Phenotype clustering in health care: A narrative review for clinicians

scientific article published in 2022

Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study

scientific article published on 07 May 2020

Predicting appendiceal tumors among patients with appendicitis

scientific article published on 17 January 2017

Preoperative assessment of the risk for multiple complications after surgery

scientific article published on 26 May 2016

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

scientific article published on 24 June 2019

Prospective Validation of a Transcriptomic Metric in Severe Trauma

scientific article published on 24 January 2019

Protective immunity and defects in the neonatal and elderly immune response to sepsis

scientific article published on 03 March 2014

Reply to "Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies"

scientific article published on 04 November 2020

Role of Toll-like receptors in the development of sepsis

scientific article published on March 2008

Routine surveillance cholangiography after percutaneous cholecystostomy delays drain removal and cholecystectomy

scientific article published on 23 November 2016

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome

scientific article published on 14 September 2016

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients

scientific article

Sepsis and the dendritic cell

scientific article published on November 2003

Sepsis induces early alterations in innate immunity that impact mortality to secondary infection

scientific article

Septic Stability? Gut Microbiota in Young Adult MICE Maintains Overall Stability After Sepsis Compared to Old Adult MICE

scientific article published on 20 August 2020

Severe trauma and chronic stress activates extramedullary erythropoiesis

scientific article published on 27 April 2017

Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock

scientific article published on 14 June 2016

Single Cell RNA-SEQ of Human Myeloid Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets with Unique Transcriptional Responses: A Pilot Study

scientific article published on 05 October 2020

Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia

scientific article published on 01 January 2005

Successful Rescue Therapy for Severe Acute Anemia: Managing the Critically Ill Jehovah's Witness.

scientific article published in June 2015

Successful aging: Advancing the science of physical independence in older adults.

scientific article

Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit

scientific article published on 26 May 2015

Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes

scientific article published on 13 November 2017

Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma

scientific article published on 14 June 2019

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis

scientific article

Temporary abdominal closure for trauma and intra-abdominal sepsis: Different patients, different outcomes.

scientific article

The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019

scientific article published on 29 April 2020

The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs

scientific article published on 01 April 2019

The Effect of Aging Physiology on Critical Care

scientific article published on 28 October 2020

The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk

scientific article published in 2022

The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two-Level One Trauma Centers

scientific article

The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury and Sepsis: A Review of Pathophysiology

scientific article published on 23 November 2020

The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma

scientific article published on 01 February 2019

The Monocyte That Wasn't

scientific article published on July 2015

The Postinjury Inflammatory State and the Bone Marrow Response to Anemia

scientific article published on 01 September 2018

The acute immunological response to blood transfusion is influenced by polymicrobial sepsis

scientific article

The authors reply

The effects of beta blockade and clonidine on persistent injury-associated anemia

scientific article published on 28 June 2018

The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress

scientific article published on 21 February 2019

The effects of red cell transfusion donor age on nosocomial infection among trauma patients.

scientific article published on 12 July 2017

The effects of selective beta-adrenergic blockade on bone marrow dysfunction following severe trauma and chronic stress

scientific article published on 25 July 2020

The future of murine sepsis and trauma research models

scientific article

The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients

scientific article published on 01 August 2018

The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy

scientific article published on 01 April 2019

The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States

scientific article

The role of bone marrow microRNA (miR) in erythropoietic dysfunction after severe trauma

scientific article published on 04 January 2021

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis

scientific article published on 02 November 2020

Unique transcriptomic response to sepsis is observed among patients of different age groups.

scientific article published on 8 September 2017

VITAMIN D STATUS IS ASSOCIATED WITH HEPCIDIN AND HEMOGLOBIN CONCENTRATIONS IN PATIENTS WITH SEVERE TRAUMATIC INJURY

scientific article published on 28 July 2020

Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery

scientific article published on 01 November 2005

What's New in Shock, April 2018?

scientific article published in April 2018

What's New in Shock, December 2019?

scientific article published on 01 December 2019

What's New in Shock, September 2020?

scientific article published on 01 September 2020

β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence

scientific article published on 11 May 2016

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