List of works - Clemens Ruppert

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

scientific article published on 10 September 2015

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

scientific article published on 27 August 2014

Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis.

scientific article published in February 2015

Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases

scientific article

An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid

scientific article published in February 2002

Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease

scientific article published on 21 October 2021

Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: Role of surfactant protein B and C

scientific article published on 01 August 2014

Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles

scientific article published on 01 November 2013

Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro

scientific article published on 06 November 2010

Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis

scientific article published on 10 May 2022

Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs

scientific article published in April 2002

Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis

scientific article published in March 2004

Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.

scientific article

Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.

scientific article

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors

scientific article published on 6 May 2013

Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs

scientific article

Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis

scientific article published in PLoS ONE

Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application

scientific article

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.

scientific article published on 6 April 2015

Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung

scientific article published in July 2010

Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis

scientific article

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia

scientific article

Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank

scientific article published on 09 May 2019

Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation

scientific article

Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C

scientific article published on 06 September 2002

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

scientific article

Impact of surface tension on the conversion rate of large to small surfactant aggregates

scientific article published on 01 May 2003

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs

scientific article published on March 2010

Inhibition of Urokinase Activity Reduces Primary Tumor Growth and Metastasis Formation in a Murine Lung Carcinoma Model

scientific article published on 07 January 2010

Is fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

scientific article

Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations

scientific article

Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model

scientific article published on 8 May 2015

Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion.

scientific article

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

scientific article published on 11 December 2019

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro

scientific article published on 30 December 2015

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

scientific article published in Nature Communications

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

scientific article published on 11 June 2019

Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids

scientific article

Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis

scientific article

Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits

scientific article

Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome

scientific article published on 01 September 2006

Recombinant Surfactant Protein C–based Surfactant for Patients with Severe Direct Lung Injury ⬇️

scientific article published on December 10, 2010

Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase

scientific article published in December 2008

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

scientific article published on 26 April 2019

Regulation of immunoproteasome function in the lung

scientific article published on 19 May 2015

Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis

scientific article published on 3 June 2015

Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis

scientific article

Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type

scientific article

Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model

scientific article published on 27 April 2017

Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis

scientific article published on 20 August 2019

Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension

scientific article published on 14 October 2020

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

scientific article published on 17 May 2019

Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration

scientific article

Tissue remodelling in pulmonary fibrosis

scientific article published on 16 December 2016

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis ⬇️

scientific article published on June 1, 2012

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair

scientific article published on 27 November 2019

List of works by Clemens Ruppert

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis.

Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases

An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid

Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease

Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: Role of surfactant protein B and C

Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles

Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro

Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis

Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs

Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis

Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.

Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.

Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors

Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs

Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis

Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.

Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung

Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia

Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank

Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation

Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

Impact of surface tension on the conversion rate of large to small surfactant aggregates

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs

Inhibition of Urokinase Activity Reduces Primary Tumor Growth and Metastasis Formation in a Murine Lung Carcinoma Model

Is fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations

Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model

Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion.

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids

Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis

Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits

Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome

Recombinant Surfactant Protein C–based Surfactant for Patients with Severe Direct Lung Injury ⬇️

Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

Regulation of immunoproteasome function in the lung

Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis

Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis

Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type

Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model

Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis

Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration

Tissue remodelling in pulmonary fibrosis

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis ⬇️

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair