List of works - Hyun-Dong Chang

1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells

scientific article published in August 2008

A Ca(2+) concentration of 1.5 mM, as present in IMDM but not in RPMI, is critical for maximal response of Th cells to PMA/ionomycin

scientific article

A critical control element for interleukin-4 memory expression in T helper lymphocytes

scientific article

A long-term perspective on immunity to COVID

scholarly article

Antigen-driven PD-1+TOX+BHLHE40+ and PD-1+TOX+EOMES+ T lymphocytes regulate juvenile idiopathic arthritis in situ

scientific article published on 09 December 2020

Authentic IgM Fc Receptor (FcμR).

scientific article published on 13 July 2017

Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts

scientific article published on 11 March 2014

Autoregulation of Th1-mediated inflammation by twist1.

scientific article published on 28 July 2008

CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

scientific article published on 30 January 2019

Cell population identification using fluorescence-minus-one controls with a one-class classifying algorithm

scientific article published on 27 August 2014

Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops

scientific article published on 01 June 2019

Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells

scientific article published in 2022

Deep phenotypical characterization of human CD3+ CD56+ T cells by mass cytometry

scientific article published on 24 November 2020

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.

scientific article published on 4 March 2015

Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF).

scientific article published on 16 September 2016

Direct uptake of Antagomirs and efficient knockdown of miRNA in primary B and T lymphocytes

scientific article published on 14 July 2015

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

scientific article published on 22 May 2020

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice

scientific article published in June 2011

Diversity and flexibility of Th17 effector functions.

scientific article published on 18 April 2011

Eomes controls the development of Th17-derived (non-classic) Th1 cells during chronic inflammation

article

Epigenetic control of the foxp3 locus in regulatory T cells

scientific article

Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

scientific article published on November 2016

Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3.

scientific article published in March 2007

Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma

publication published on 01 January 2022

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

scholarly article

High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition

scientific article

Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells

scientific article

Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory

scientific article

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

scientific article published in November 2010

IL-10 is excluded from the functional cytokine memory of human CD4+ memory T lymphocytes.

scientific article published in August 2007

IL-10-producing B cells are characterized by a specific methylation signature

scientific article published on 07 May 2019

IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

scientific article published in June 2014

IL-1β and TGF-β act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells.

scientific article

IMprinting of PAthogenic Memory in Berlin

scientific article published in March 2013

Immunological memories of the bone marrow.

scientific article published in May 2018

Immunological memory in rheumatic inflammation — a roadblock to tolerance induction

scholarly article

Innate-like effector differentiation of human invariant NKT cells driven by IL-7.

scientific article published in April 2008

Keeping up with the stress of antibody production: BAFF and APRIL maintain memory plasma cells

scholarly article

Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo

scientific article published on 04 December 2009

Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature

scientific article published on 18 December 2017

Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-γ memory in human CD4(+) T lymphocytes.

scientific article published in March 2013

Lymphocyte signaling: regulation of FoxO transcription factors by microRNAs

scientific article published on 11 January 2012

Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation.

scientific article published on 16 August 2017

Maintenance of quiescent immune memory in the bone marrow

scholarly article

Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription

scientific article

MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes

scientific article published on 06 December 2018

Microorganisms and their activities within microbial communities

scientific article published on 24 June 2020

NK cells gain higher IFN-γ competence during terminal differentiation

scientific article published on 19 May 2014

Nitric oxide enhances Th9 cell differentiation and airway inflammation

scientific article

Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow.

scientific article

Nuclear factor of activated T cells regulates the expression of interleukin-4 in Th2 cells in an all-or-none fashion

scientific article published on 17 July 2014

Organization and maintenance of immunological memory by stroma niches

scientific article published on August 2009

Pathogenic memory plasma cells in autoimmunity

scientific article published on 30 October 2019

Persistence of effector memory Th1 cells is regulated by Hopx

scientific article published on 27 October 2010

Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells

scientific article published on November 2006

Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn’s Disease

scholarly article

Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation

scientific article published on 05 September 2019

Resident memory CD4<sup>+</sup> T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

scientific article published in 2022

Rethinking ‘immunological memory’: Local and systemic immunity provided by bone marrow‐resident memory cells

scholarly article

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

scientific article

Selection and depletion of plasma cells based on the specificity of the secreted antibody

scientific article published on 2 November 2014

Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo

scientific article published on 25 November 2017

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.

scientific article

Single-cell transcriptomes of murine bone marrow stromal cells reveal niche-associated heterogeneity

scientific article published on 07 June 2019

Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer's patches in mice

scientific article published on 17 February 2020

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

scientific article published on 30 May 2014

Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

scientific article published on 01 August 2020

T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation

scientific article published in 2021

Targeting pathogenic T helper cell memory

scientific article published on March 2011

Th memory for interleukin-17 expression is stable in vivo.

scientific article published in October 2008

The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice.

scientific article published on 6 September 2017

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.

scientific article published on 10 October 2010

The pro- and anti-inflammatory potential of IL-12: the dual role of Th1 cells.

scientific article published in September 2007

The pro- and anti-inflammatory potential of interleukin-12.

scientific article published in August 2007

Unbiased transcriptomes of resting human CD4⁺ CD45RO⁺ T lymphocytes

scientific article

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis

scientific article published on 18 February 2019

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.

scientific article published on 22 January 2015

List of works by Hyun-Dong Chang

1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells

A Ca(2+) concentration of 1.5 mM, as present in IMDM but not in RPMI, is critical for maximal response of Th cells to PMA/ionomycin

A critical control element for interleukin-4 memory expression in T helper lymphocytes

A long-term perspective on immunity to COVID

Antigen-driven PD-1+TOX+BHLHE40+ and PD-1+TOX+EOMES+ T lymphocytes regulate juvenile idiopathic arthritis in situ

Authentic IgM Fc Receptor (FcμR).

Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts

Autoregulation of Th1-mediated inflammation by twist1.

CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

Cell population identification using fluorescence-minus-one controls with a one-class classifying algorithm

Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops

Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells

Deep phenotypical characterization of human CD3+ CD56+ T cells by mass cytometry

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.

Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF).

Direct uptake of Antagomirs and efficient knockdown of miRNA in primary B and T lymphocytes

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice

Diversity and flexibility of Th17 effector functions.

Eomes controls the development of Th17-derived (non-classic) Th1 cells during chronic inflammation

Epigenetic control of the foxp3 locus in regulatory T cells

Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3.

Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell non-Hodgkin lymphoma

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition

Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells

Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

IL-10 is excluded from the functional cytokine memory of human CD4+ memory T lymphocytes.

IL-10-producing B cells are characterized by a specific methylation signature

IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

IL-1β and TGF-β act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells.

IMprinting of PAthogenic Memory in Berlin

Immunological memories of the bone marrow.

Immunological memory in rheumatic inflammation — a roadblock to tolerance induction

Innate-like effector differentiation of human invariant NKT cells driven by IL-7.

Keeping up with the stress of antibody production: BAFF and APRIL maintain memory plasma cells

Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo

Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature

Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-γ memory in human CD4(+) T lymphocytes.

Lymphocyte signaling: regulation of FoxO transcription factors by microRNAs

Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation.

Maintenance of quiescent immune memory in the bone marrow

Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription

MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes

Microorganisms and their activities within microbial communities

NK cells gain higher IFN-γ competence during terminal differentiation

Nitric oxide enhances Th9 cell differentiation and airway inflammation

Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow.

Nuclear factor of activated T cells regulates the expression of interleukin-4 in Th2 cells in an all-or-none fashion

Organization and maintenance of immunological memory by stroma niches

Pathogenic memory plasma cells in autoimmunity

Persistence of effector memory Th1 cells is regulated by Hopx

Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells

Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn’s Disease

Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation

Resident memory CD4<sup>+</sup> T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

Rethinking ‘immunological memory’: Local and systemic immunity provided by bone marrow‐resident memory cells

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Selection and depletion of plasma cells based on the specificity of the secreted antibody

Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.

Single-cell transcriptomes of murine bone marrow stromal cells reveal niche-associated heterogeneity

Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer's patches in mice

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation

Targeting pathogenic T helper cell memory

Th memory for interleukin-17 expression is stable in vivo.

The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice.

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.

The pro- and anti-inflammatory potential of IL-12: the dual role of Th1 cells.

The pro- and anti-inflammatory potential of interleukin-12.

Unbiased transcriptomes of resting human CD4⁺ CD45RO⁺ T lymphocytes

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.