List of works - Julie A Frearson

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

scientific article published on 23 August 2012

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

scientific article

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

scientific article published on 9 April 2013

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

scientific article published on 25 May 2016

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors

scientific article

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

scientific article

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

scientific article

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

scientific article

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

scientific article published on 29 September 2015

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

scientific article published on 18 September 2015

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

scientific article

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

scientific article published on 10 September 2016

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

scholarly article published in Antimicrobial Agents and Chemotherapy

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

scientific article

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

scientific article

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

scientific article

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

scientific article

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

scientific article

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488

scientific article

Quinol derivatives as potential trypanocidal agents

scientific article published on 27 December 2011

Screening a protein kinase inhibitor library against Plasmodium falciparum

scientific article published on 7 November 2017

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

scientific article

Target assessment for antiparasitic drug discovery

scientific article

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

scientific article published on 17 June 2016

List of works by Julie A Frearson

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488

Quinol derivatives as potential trypanocidal agents

Screening a protein kinase inhibitor library against Plasmodium falciparum

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

Target assessment for antiparasitic drug discovery

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials