List of works - Michele C Connelly

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

scientific article

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

scientific article published on 10 July 2020

Chemical genetics of Plasmodium falciparum

scientific article (publication date: 20 May 2010)

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

scientific article published on 4 January 2008

Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites

scientific article

Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening

scientific article published on 23 January 2013

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.

scientific article published on 29 December 2017

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

scientific article published on 8 April 2008

Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

scientific article (publication date: 10 May 2016)

Evaluation of Diarylureas for Activity Against Plasmodium falciparum.

scientific article

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

scientific article published on 4 November 2017

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

scientific article

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

scientific article

Lead optimization of antimalarial propafenone analogues.

scientific article published on 29 June 2012

Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.

scientific article

Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription

scientific article

Optimization of propafenone analogues as antimalarial leads

scientific article published on 10 October 2011

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.

scientific article

Repositioning: the fast track to new anti-malarial medicines?

scientific article

Structure-guided development of selective TbcatB inhibitors

scientific article published on October 2009

Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity

scientific article published on 26 September 2011

Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.

scientific article published on 11 February 2010

List of works by Michele C Connelly

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

Chemical genetics of Plasmodium falciparum

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites

Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

Evaluation of Diarylureas for Activity Against Plasmodium falciparum.

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

Lead optimization of antimalarial propafenone analogues.

Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.

Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription

Optimization of propafenone analogues as antimalarial leads

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.

Repositioning: the fast track to new anti-malarial medicines?

Structure-guided development of selective TbcatB inhibitors

Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity

Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.