List of works - Sijy O'Dell

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

scientific article

Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables

scientific article

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies

scientific article published on 15 October 2008

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

scientific article

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

scientific article published on June 29, 2011

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

scientific article

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

scientific article

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

scientific article

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

scientific article published on November 2016

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

scientific article

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

scientific article

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

scientific article

Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment

scientific article published on 19 August 2009

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

scientific article published on 14 July 2020

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

scientific article published on January 28, 2015

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

scientific article

Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site

scientific article published on March 14, 2012

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline

scientific article published on January 3, 2014

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes

scientific article published on 18 January 2012

Activation and lysis of human CD4 cells latently infected with HIV-1

scientific article

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

scientific article published on 08 October 2013

HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

scientific article published on August 8, 2012

Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein.

scientific article

Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics

scientific article

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

scientific article

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

scientific article published on 8 March 2017

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

scientific article

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

scientific article published on 04 March 2009

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

scientific article

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

scientific article published on 28 July 2020

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

scientific article published on May 2017

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

scientific article

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

scientific article published on December 11, 2013

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

scientific article

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

scientific article published on 28 February 2018

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

scientific article published in February 2018

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

scientific article

List of works by Sijy O'Dell

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes

Activation and lysis of human CD4 cells latently infected with HIV-1

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein.

Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites