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List of works by Krisha McKee

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

scientific article published on 10 March 2014

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

scientific article

Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens

scientific article published on 21 April 2012

Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.

scientific article

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

article

Correction for Ingale et al., Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

scientific article published on June 2015

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

scientific article published on 08 October 2013

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

scientific article

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

scientific article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Eliminating antibody polyreactivity through addition of N-linked glycosylation

scientific article published on 12 May 2015

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

scientific article

Enhancing the Solubility of HIV-1-neutralizing Antibody 10E8.

scientific article published in October 2014

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes

scientific article published on 18 January 2012

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

scientific article

Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

scientific article

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

article

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

scientific article published in Nature Communications

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

scientific article

Maturation Pathways for the Broad and Potent Antibody 10E8 Using a Combination of Next Generation Sequencing, Bioinformatics and Functional Analysis

scientific article published in October 2014

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 ⬇️

scientific article published on June 29, 2011

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

scientific article published on 27 March 2013

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

scientific article

Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

scientific article published on 21 September 2016

Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs.

scientific article published on 11 April 2018

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

scientific article

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

scientific article

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

scientific article

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

scientific article published on 20 February 2020

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

scientific article published on 28 February 2018

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region

scientific article

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

scientific article published on 01 January 2020

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

scientific article published on March 2017

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

scientific article

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

scientific article

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

article

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

scientific article published on 01 April 2020

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

scientific article published in February 2018

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

scientific article

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

scientific article published on 16 February 2018

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

scientific article published on 12 November 2019

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

scientific article

Variable Dependence on Glycan Recognition within a Lineage of V1V2-directed HIV Neutralizing Antibodies.

scientific article published in October 2014

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