List of works by Jacob Nattermann

A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease

scientific article

A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis.

scientific article published on 30 July 2014

A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice

scientific article

A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

scientific article published in Scientific Reports

A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.

scientific article published on 28 September 2015

Alterations of the NK cell pool in HIV/HCV co-infection

scientific article

An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients.

scientific article published on 21 January 2014

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

scientific article published on 6 May 2014

Antibiotic resistance in healthcare-related and nosocomial spontaneous bacterial peritonitis.

scientific article

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats

scientific article published on 13 August 2012

Between Scylla and Charybdis: the role of the human immune system in the pathogenesis of hepatitis C.

scientific article

Bile microbiome varies by etiology of cholestatic liver disease

scientific article published on 03 September 2020

CD27(+)CD56Bright natural killer cells may be involved in spontaneous clearance of acute hepatitis C in HIV-positive patients.

scientific article published on August 2014

CD3(+)CD56(+) Natural Killer-Like T Cells Display Anti-HCV Activity but Are Functionally Impaired in HIV(+) Patients With Acute Hepatitis C.

scientific article published on December 2015

CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins

scientific article published on 2 March 2011

Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study

scientific article published on 24 May 2020

Chromoendoscopy in combination with random biopsies does not improve detection of gastric cancer foci in CDH1 mutation positive patients

scientific article published on 31 August 2016

Colonoscopy detects significantly more flat adenomas than 3-tesla magnetic resonance colonography: a pilot trial

scientific article published on 28 January 2016

Combined photodynamic therapy with systemic chemotherapy for unresectable cholangiocarcinoma

scientific article published on 13 January 2019

Comparative study of NK cell-mediated cytotoxicity using radioactive and flow cytometric cytotoxicity assays

scientific article published on 13 September 2005

Comparison of GB virus C, HIV, and HCV infection markers in hemophiliacs exposed to non-inactivated or inactivated factor concentrates

scientific article published in September 2005

Compartment-specific distribution of human intestinal innate lymphoid cells is altered in HIV patients under effective therapy

scientific article

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

scientific article published on 28 December 2021

Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures

scientific article

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

scientific article

Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection -- a prospective cross-sectional study

scientific article published on December 2005

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes

scientific article published on 28 January 2016

Do lambda-IFNs IL28A and IL28B act on human natural killer cells?

scientific article published on 8 August 2011

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Effect of the interleukin-6 C174G gene polymorphism on treatment of acute and chronic hepatitis C in human immunodeficiency virus coinfected patients.

scientific article published on October 2007

Effects of HCV co-infection on apoptosis of CD4+ T-cells in HIV-positive patients

scientific article published on 14 May 2009

Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia.

scientific article published on January 2009

Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia.

scientific article published in January 2009

Endoscopic Ultrasound-Guided Drainage and Treatment of Symptomatic Pancreatic Fluid Collection following Acute or Acute-on-Chronic Pancreatitis - A Single Center Case Series

scientific article published on 11 July 2018

Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

scientific article (publication date: December 2008)

Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS).

scientific article published on 29 November 2017

FibroGENE: A gene-based model for staging liver fibrosis

scientific article published on 16 November 2015

First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)"

scientific article published on 01 October 2020

Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.

scientific article

Genomic and transcriptomic heterogeneity of colorectal tumors arising in Lynch Syndrome

scientific article published on 20 July 2017

HIV mono-infection is associated with an impaired anti-hepatitis C virus activity of natural killer cells

scientific article

HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells

scientific article published on 01 January 2005

HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection

scientific article

Hepatitis C coinfection enhances sensitization of CD4(+) T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients.

scientific article published in January 2011

Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C.

scientific article published in October 2006

Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2.

scientific article published on 2 May 2011

Hepatitis C virus infection and genetic susceptibility to therapy.

scientific article published on December 2011

Hepatitis C virus-induced secretion of inflammatory chemokines preferentially recruits NKG2A+CD8+ T cells

scientific article published in July 2008

Hereditary Diffuse Gastric Cancer: A Comparative Cohort Study According to Pathogenic Variant Status

scientific article published on 11 December 2020

Host genetic factors and treatment of hepatitis C.

scientific article published on June 2008

Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infection

scientific article published on 19 August 2015

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

scientific article published on 10 April 2017

IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection

scientific article published on 24 April 2014

IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C.

scientific article published on September 2016

IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study

scientific article

Immunopathogenesis in hepatitis C virus cirrhosis

scientific article published on February 2007

Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

scientific article

Impaired CD4⁺ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients.

scientific article published on 9 May 2013

Increased peripheral CD4+ regulatory T cells persist after successful direct-acting antiviral treatment of chronic hepatitis C.

scientific article

Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma.

scientific article published in August 2006

Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent

scientific article published on 18 November 2013

Interferon-lambda serum levels in hepatitis C.

scientific article published on 23 October 2010

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.

scientific article

Intrahepatic activation of caspases in human fulminant hepatic failure

scientific article published on 01 September 2006

KIR2DL3⁺NKG2A⁻ natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs.

scientific article published on 26 April 2014

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

scientific article published on 26 November 2020

Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C

scientific article published on 27 November 2009

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.

scientific article published on 15 September 2016

Misery acquaints a man with dangerous bedfellows: But how to get rid of them?

scientific article published in October 2017

Mo1726 – Chromoendoscopy Leads to a Higher Spigelman-Stage in Patients with Familial Adenomatous Polyposis (CHROPOL I)

scholarly article

NK Cells in Ascites From Liver Disease Patients Display a Particular Phenotype and Take Part in Antibacterial Immune Response

scientific article published on 07 August 2019

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

scientific article published on 26 March 2012

Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis.

scientific article published on 31 August 2012

Neither black nor white: do altered intestinal microbiota reflect chronic liver disease severity?

scientific article published on 05 June 2020

Pegylated interferon-alpha for the treatment of sexually transmitted acute hepatitis C in HIV-infected individuals.

scientific article published in January 2006

Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load

scientific article published on 13 December 2011

Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2.

scientific article published on 10 February 2006

Prophylactic total gastrectomy in the management of hereditary tumor syndromes

scientific article published on 28 September 2016

Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction

scientific article

Regulation of CC chemokine receptor 5 in hepatitis G virus infection

scientific article published in July 2003

Regulation of NK cell trafficking by CD81.

scientific article

Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type.

scientific article published on 6 September 2014

Relative Ascites Polymorphonuclear Cell Count Indicates Bacterascites and Risk of Spontaneous Bacterial Peritonitis.

scientific article published on 09 June 2017

Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C.

scientific article

Role of regulatory T cells and checkpoint inhibition in hepatocellular carcinoma

scientific article published on 13 November 2019

Role of the NK cell-activating receptor CRACC in periodontitis.

scientific article published on 17 December 2012

Selective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level

scientific article

Semiquantitative analysis of intrahepatic CC-chemokine mRNas in chronic hepatitis C

scientific article (publication date: December 2004)

Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC).

scientific article published on 21 January 2005

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

scientific article published on 05 August 2020

Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes

scientific article

Swarm Learning for decentralized and confidential clinical machine learning

scientific article

TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients.

scientific article

The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance

scientific article published on 19 July 2020

The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients

scientific article published on 13 December 2011

The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C

scientific article

The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients

scientific article published on 24 May 2007

The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells

scientific article published on February 2005

The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells.

scientific article published on November 2009

The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu

scientific article published on 21 October 2019

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis

scientific article

The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection.

scientific article published in August 2010

The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation

article

The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

scientific article

The role of CCR5 in HCV infection

scientific article

The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C.

scientific article published on 18 June 2011

The transforming growth factor-beta high-producer genotype is associated with response to hepatitis C virus-specific therapy in HIV-positive patients with acute hepatitis C.

scientific article published in July 2008

Transpapillary tissue sampling of biliary strictures: balloon dilatation prior to forceps biopsy improves sensitivity and accuracy

scientific article published on 15 October 2020

Tu1669 – Chromoendoscopy Leads to a Higher Insight-Stage in Patients with Familial Adenomatous Polyposis (CHROPOL II)

scholarly article

Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome

scientific article published on 15 September 2020

Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C.

scientific article published on November 2013

[Current recommendations for surveillance, risk reduction and therapy in Lynch syndrome patients]

scientific article published on 18 November 2019

[Outcomes after Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer]

scientific article published on 01 August 2018

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