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List of works by Laurence Collette

A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-o

scientific article

A Systematic Review and Recommendation for Reporting of Surrogate Endpoint Evaluation Using Meta-analyses

scientific article published on 06 February 2019

A multinational, multi-tumour basket study in very rare cancer types: The European Organization for Research and Treatment of Cancer phase II 90101 'CREATE' trial

scientific article published on 14 January 2019

A new measure of treatment effect in clinical trials involving competing risks based on generalized pairwise comparisons

scientific article published on 16 September 2020

Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials

scientific article published in 2022

Adjuvant Gemcitabine Alone Versus Gemcitabine-Based Chemoradiotherapy After Curative Resection for Pancreatic Cancer: A Randomized EORTC-40013-22012/FFCD-9203/GERCOR Phase II Study ⬇️

scientific article published on September 13, 2010

Adjuvant Radiotherapy After Surgery for Pathologically Advanced Prostate Cancer

scientific article published on 01 December 2007

Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data

scientific article

Adjuvant chemotherapy for rectal cancer--authors' reply

scientific article published on 01 May 2014

Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: A phase-II parallel non-randomized and observation study (EORTC 22042-26042)

scientific article published on 28 June 2018

Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study

scientific article

Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards ⬇️

scientific article

Are prostate-specific antigen changes valid surrogates for survival in hormone-refractory prostate cancer? A meta-analysis is needed!

scientific article published in December 2007

Association of Gleason Grade With Androgen Deprivation Therapy Duration and Survival Outcomes: A Systematic Review and Patient-Level Meta-analysis

scientific article published on 01 January 2019

BPA uptake does not correlate with LAT1 and Ki67 expressions in tumor samples (results of EORTC trial 11001)

scientific article published on 16 February 2011

Bone marrow MRI versus 18F-FDG-PET/CT for detecting multiple myeloma lesions: diagnostic performance and clinical relevance ⬇️

scholarly article

CMET-43. COMPARISON OF LOCAL CONTROL OF BRAIN METASTASES WITH STEREOTACTIC RADIOSURGERY VERSUS SURGICAL RESECTION: A SECONDARY ANALYSIS OF EORTC 22952–26001

Can radical prostatectomy benefit patients despite the presence of regional metastases?

scientific article published on 22 January 2010

Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer?

scientific article published on 17 February 2012

Characterisation and classification of oligometastatic disease: a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation

scientific article published on 01 January 2020

Chemotherapy with preoperative radiotherapy in rectal cancer

scientific article

Clinical trial designs for predictive marker validation in cancer treatment trials

scientific article published in March 2005

Collaboration between EORTC and JCOG-how to accelerate global clinical research partnership

scientific article

Comparison of Immediate vs Deferred Cytoreductive Nephrectomy in Patients With Synchronous Metastatic Renal Cell Carcinoma Receiving Sunitinib: The SURTIME Randomized Clinical Trial

scientific article published on 01 February 2019

Comparison of Local Control of Brain Metastases With Stereotactic Radiosurgery vs Surgical Resection: A Secondary Analysis of a Randomized Clinical Trial

scientific article published on 01 February 2019

Cumulative Toxicity in Targeted Therapies: What to Expect at the Recommended Phase II Dose

scientific article published on 01 November 2019

Defining dose-limiting toxicity for phase 1 trials of molecularly targeted agents: results of a DLT-TARGETT international survey.

scientific article

Differences in time to disease progression do not predict for cancer-specific survival in patients receiving immediate or deferred androgen-deprivation therapy for prostate cancer: final results of EORTC randomized trial 30891 with 12 years of follo

scientific article published on 24 July 2013

Does local treatment of the prostate in advanced and/or lymph node metastatic disease improve efficacy of androgen-deprivation therapy? A systematic review

scientific article published on 27 May 2010

Dose-Finding Methods: Moving Away from the 3 + 3 to Include Richer Outcomes.

scientific article published on 19 June 2017

Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning.

scientific article published on 6 April 2010

Duration of androgen suppression in the treatment of prostate cancer

scientific article published in June 2009

EORTC 22972-26991/MRC BR10 trial: fractionated stereotactic boost following conventional radiotherapy of high grade gliomas. Clinical and quality-assurance results of the stereotactic boost arm.

scientific article

EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non-Muscle-invasive Stage Ta-T1 Urothelial Bladder Cancer Patients Treated with 1-3 Years of Maintenance Bacillus Calmette-Guérin.

scientific article published on 22 July 2015

EORTC prostate cancer trials: what have we learnt?

scientific article

EORTC trial 11001: distribution of two 10B-compounds in patients with squamous cell carcinoma of head and neck, a translational research/phase 1 trial.

scientific article published on 10 July 2009

EORTC-ROG expert opinion: radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach

scientific article published on 15 April 2009

ESMO-MCBS: setting the record straight - Authors' reply

scientific article published on 01 April 2019

Early versus delayed endocrine treatment of T2-T3 pN1-3 M0 prostate cancer without local treatment of the primary tumour: final results of European Organisation for the Research and Treatment of Cancer protocol 30846 after 13 years of follow-up (a r

scientific article

Early versus delayed endocrine treatment of pN1-3 M0 prostate cancer without local treatment of the primary tumor: results of European Organisation for the Research and Treatment of Cancer 30846--a phase III study

scientific article

Editorial comment

Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881-10882.

scientific article published on 28 November 2006

Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results--EORTC 22921.

scientific article

European Organisation of Research and Treatment of Cancer (EORTC) Gastrointestinal Group: Workshop on the role of metabolic imaging in the neoadjuvant treatment of gastrointestinal cancer.

scientific article published on 17 July 2008

Event-Free Survival, a Prostate-Specific Antigen-Based Composite End Point, Is Not a Surrogate for Overall Survival in Men With Localized Prostate Cancer Treated With Radiation

scientific article published on 18 June 2020

Expression of the androgen-regulated fusion gene TMPRSS2-ERG does not predict response to endocrine treatment in hormone-naïve, node-positive prostate cancer

scientific article published on 22 August 2009

External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study.

scientific article published on 7 October 2010

Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study

scientific article

From a Comic Opera to Surcare an Open Letter to Whom Clinical Research in Surgery Is a Concern: Announcing the Launch of SURCARE

scientific article published on 01 December 2016

Guidelines for time-to-event end-point definitions in trials for pancreatic cancer. Results of the DATECAN initiative (Definition for the Assessment of Time-to-event End-points in CANcer trials).

scientific article published on 22 September 2014

Identification of patients with prostate cancer who benefit from immediate postoperative radiotherapy: EORTC 22911.

scientific article published on September 2007

Immediate or deferred androgen deprivation for patients with prostate cancer not suitable for local treatment with curative intent: European Organisation for Research and Treatment of Cancer (EORTC) Trial 30891

scientific article published on 01 April 2006

Immediate versus deferred chemotherapy after radical cystectomy in patients with pT3-pT4 or N+ M0 urothelial carcinoma of the bladder (EORTC 30994): an intergroup, open-label, randomised phase 3 trial

scientific article

Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial

scientific article published on 18 June 2007

Impact of acute kidney injury on anticancer treatment dosage and long-term outcomes: a pooled analysis of European Organisation for Research and Treatment of Cancer trials

scientific article published on 26 April 2020

Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial

scientific article

Impact of pathology review of stage and margin status of radical prostatectomy specimens (EORTC trial 22911).

scientific article published on 29 August 2006

Impact of primary tumor location on survival from EORTC advanced urothelial cancer studies.

scientific article published on 17 November 2017

Impact of the COVID-19 crisis on imaging in oncological trials

scientific article published on 12 June 2020

Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial

scientific article published on 15 August 2008

Implications of prostate-specific antigen doubling time as indicator of failure after surgery or radiation therapy for prostate cancer

scientific article published on 13 November 2006

In Reply:

Intermittent maximal androgen blockade in patients with metastatic prostate cancer: an EORTC feasibility study

scientific article published in November 2003

Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer

scientific article published on July 2015

International evaluation of the psychometrics of health-related quality of life questionnaires for use among long-term survivors of testicular and prostate cancer ⬇️

scientific article

International standards for the analysis of quality-of-life and patient-reported outcome endpoints in cancer randomised controlled trials: recommendations of the SISAQOL Consortium

scientific article published on 01 February 2020

Is baseline quality of life useful for predicting survival with hormone-refractory prostate cancer? A pooled analysis of three studies of the European Organisation for Research and Treatment of Cancer Genitourinary Group

scientific article

Is prostate-specific antigen a valid surrogate end point for survival in hormonally treated patients with metastatic prostate cancer? Joint research of the European Organisation for Research and Treatment of Cancer, the Limburgs Universitair Centrum

scientific article published in September 2005

Late toxicity following conventional radiotherapy for prostate cancer: analysis of the EORTC trial 22863

Local Failure and Survival After Definitive Radiotherapy for Aggressive Prostate Cancer: An Individual Patient-level Meta-analysis of Six Randomized Trials

scientific article published on 10 November 2019

Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial

scientific article

MRI versus 18F-FDG-PET/CT for detecting bone marrow involvement in multiple myeloma: diagnostic performance and clinical relevance

scientific article published on 16 December 2019

Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer

scientific article published on 10 August 2017

Metastatic prostate cancer treated by flutamide versus cyproterone acetate. Final analysis of the "European Organization for Research and Treatment of Cancer" (EORTC) Protocol 30892.

scientific article published in April 2004

Morbidity from pelvic lymphadenectomy in men undergoing radical prostatectomy

scientific article published on 23 August 2006

Moving forward toward standardizing analysis of quality of life data in randomized cancer clinical trials ⬇️

article by Andrew Bottomley et al published December 2018 in Clinical Trials

N-of-1 trials in oncology

scientific article published on August 2015

Nomogram to predict ipsilateral breast relapse based on pathology review from the EORTC 22881-10882 boost versus no boost trial.

scientific article published on July 2011

Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials

scientific article published on 11 July 2011

One-step TNM staging of high-risk prostate cancer using magnetic resonance imaging (MRI): toward an upfront simplified "all-in-one" imaging approach?

scientific article published on 24 December 2013

Overall Survival in Men With Bone Metastases From Castration-Resistant Prostate Cancer Treated With Bone-Targeting Radioisotopes: A Meta-analysis of Individual Patient Data From Randomized Clinical Trials

scientific article published on 12 December 2019

Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial

article

P52 Can the forest plot be simplified without loosing relevant information in meta-analyses? ⬇️

scholarly article

Palliative-care trials: how best to publish findings?

scientific article published on 01 May 2008

Patients at high risk of progression after radical prostatectomy: do they all benefit from immediate post-operative irradiation? (EORTC trial 22911)

scientific article published on 11 October 2005

Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Canc

scientific article published in October 2007

Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial

scientific article

Pooled Analysis of external-beam RADiotherapy parameters in phase II and phase III trials in radiochemotherapy in Anal Cancer (PARADAC)

scientific article published on 28 September 2019

Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911)

scientific article published on 19 October 2012

Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911)

scientific article published on 01 August 2005

Postoperative radiotherapy for high-risk prostate cancer - Authors' reply

scientific article published in March 2013

Predictive factors for the benefit of perioperative FOLFOX for resectable liver metastasis in colorectal cancer patients (EORTC Intergroup Trial 40983).

scientific article published in March 2012

Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer: a study based on the EORTC Trial 22881-10882 'boost versus no boost'

scientific article published on 29 August 2008

Profile of European radiotherapy departments contributing to the EORTC Radiation Oncology Group (ROG) in the 21st century

scientific article published on 4 June 2008

Prognostic Factors for Local Control in Breast Cancer After Long-term Follow-up in the EORTC Boost vs No Boost Trial: A Randomized Clinical Trial

scientific article published on 08 September 2016

Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology a

article

Prophylactic cranial irradiation in extensive small-cell lung cancer

scientific article

Proportional odds assumption for modeling longitudinal ordinal multiple toxicity outcomes in dose finding studies of targeted agents: A pooled analysis of 54 studies

scientific article published on 25 January 2020

Prostate cancer: to screen or not to screen?

scientific article published on 01 June 2009

Prostate specific antigen: a prognostic marker of survival in good prognosis metastatic prostate cancer? (EORTC 30892).

scientific article published in August 2003

Prostate-specific antigen (PSA) alone is not an appropriate surrogate marker of long-term therapeutic benefit in prostate cancer trials

scientific article

Prostate-specific antigen (PSA) as a surrogate end point for survival in prostate cancer clinical trials

scientific article published on 28 August 2007

Protocol of the Definition for the Assessment of Time-to-event Endpoints in CANcer trials (DATECAN) project: formal consensus method for the development of guidelines for standardised time-to-event endpoints' definitions in cancer clinical trials.

scientific article

Quality assurance in breast cancer: EORTC experiences in the phase III trial on irradiation of the internal mammary nodes

scientific article published on 19 January 2007

Quality assurance in the EORTC phase III randomised 'boost vs. no boost' trial for breast conserving therapy: comparison of the results of two individual case reviews performed early and late during the accrual period

scientific article published on 01 September 2005

Quality assurance in the EORTC randomized trial 22922/10925 investigating the role of irradiation of the internal mammary and medial supraclavicular lymph node chain works

scientific article published on October 2006

Quality assurance of the EORTC 22043-30041 trial in post-operative radiotherapy in prostate cancer: results of the Dummy Run procedure

scientific article published on 23 May 2013

Quality of life in good prognosis patients with metastatic germ cell cancer: a prospective study of the European Organization for Research and Treatment of Cancer Genitourinary Group/Medical Research Council Testicular Cancer Study Group (30941/TE20

scientific article published in March 2003

Quality of surgery in T3-4 rectal cancer: involvement of circumferential resection margin not influenced by preoperative treatment. Results from EORTC trial 22921

scientific article published on 12 July 2007

Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).

scientific article published on 15 August 2008

Randomized phase III study comparing paclitaxel-bleomycin, etoposide, and cisplatin (BEP) to standard BEP in intermediate-prognosis germ-cell cancer: intergroup study EORTC 30983.

scientific article

Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3.

scientific article

Re: Design and endpoints of clinical trials in patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group

scientific article published in August 2008

Recruiting long-term survivors of European Organisation for Research and Treatment of Cancer phase III clinical trials into quality of life studies: challenges and opportunities

scientific article published on 9 May 2014

Responding to the challenges of international collaborations between the east and the west - report of the first JCOG-EORTC symposium and a perspective from young JCOG and EORTC investigators

scientific article published on 01 January 2019

Results of the phase II EORTC 22971 trial evaluating combined accelerated external radiation and chemotherapy with 5FU and cisplatin in patients with muscle invasive transitional cell carcinoma of the bladder

scientific article published in January 2008

Robot-assisted cystectomy: does it meet expectations?

scientific article published on 2 June 2010

Sample size computation in phase II designs combining the A'Hern design and the Sargent and Goldberg design

scientific article published on 22 July 2019

Selection bias is not a good reason for advising more than 5 years of adjuvant hormonal therapy for all patients with locally advanced prostate cancer treated with radiotherapy.

scientific article published on 28 September 2009

Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer.

scientific article published on 21 February 2015

Short Androgen Suppression and Radiation Dose Escalation for Intermediate- and High-Risk Localized Prostate Cancer: Results of EORTC Trial 22991.

scientific article

Short- vs long-term androgen suppression plus external beam radiation therapy and survival in men of advanced age with node-negative high-risk adenocarcinoma of the prostate

scientific article published on 01 May 2007

Statistical analysis of patient-reported outcome data in randomised controlled trials of locally advanced and metastatic breast cancer: a systematic review ⬇️

Surgical Safety of Cytoreductive Nephrectomy Following Sunitinib: Results from the Multicentre, Randomised Controlled Trial of Immediate Versus Deferred Nephrectomy (SURTIME)

scientific article published on 18 June 2019

Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data

scientific article

The abdominoperineal resection itself is associated with an adverse outcome: the European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer

scientific article

The influence of the boost technique on local control in breast conserving treatment in the EORTC 'boost versus no boost' randomised trial

scientific article published on 01 July 2004

Timing to achieve the highest rate of pCR after preoperative radiochemotherapy in rectal cancer: a pooled analysis of 3085 patients from 7 randomized trials

scientific article published on 20 September 2020

Towards an evidence-informed value scale for surgical and radiation oncology: a multi-stakeholder perspective

scientific article published on 01 February 2019

Towards new methods for the determination of dose limiting toxicities and the assessment of the recommended dose for further studies of molecularly targeted agents--dose-Limiting Toxicity and Toxicity Assessment Recommendation Group for Early Trials

scientific article

Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 22922/10925)

scientific article published on 01 January 2010

Trial design on prophylaxis and treatment of brain metastases: lessons learned from the EORTC Brain Metastases Strategic Meeting 2012.

scientific article published on 08 August 2012

Uptake of two 10B-compounds in liver metastases of colorectal adenocarcinoma for extracorporeal irradiation with boron neutron capture therapy (EORTC Trial 11001).

scientific article published in March 2008

Use of modern imaging methods to facilitate trials of metastasis-directed therapy for oligometastatic disease in prostate cancer: a consensus recommendation from the EORTC Imaging Group

scientific article published on 01 October 2018

Using PSA to guide timing of androgen deprivation in patients with T0-4 N0-2 M0 prostate cancer not suitable for local curative treatment (EORTC 30891)

scientific article published on 27 December 2007

Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: a combined analysis of seven EORTC studies

scientific article published on 01 May 2002

What can be concluded from the ERSPC and PLCO trial data? ⬇️

scientific article published on November 1, 2010

What has been learned from meta-analyses of neoadjuvant and adjuvant chemotherapy in bladder cancer?

scientific article published on 01 September 2006

Whole body MRI in spondyloarthritis (SpA): Preliminary results suggest that DWI outperforms STIR for lesion detection

scientific article published on 17 April 2018

Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

scientific article published on 9 December 2014

pT3N0M0 prostate cancer: a plea for adjuvant radiation

scientific article published in August 2009

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