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List of works by Jan W Drijfhout

28-OR Control of HIV-1 replication: Human long-term non-progressors and chimpanzees share MHC class I molecules with similar functional properties

article

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

scientific article published on 29 August 2020

A Focal Adhesion Kinase-Derived Peptide Binds the Src SH3 Domain in Two Orientations, As Demonstrated Using Paramagnetic Nuclear Magnetic Resonance

scientific article published on 8 December 2015

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

scientific article published on 20 October 2017

A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics

scientific article published on 11 October 2017

A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins

scientific article

ABAP: antibody-based assay for peptidylarginine deiminase activity

scientific article published on 21 July 2007

ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression

scientific article

AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz

scientific article

Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes

scientific article published on 19 July 2014

Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial

scientific article published on 21 November 2012

Allo-HLA-reactive T cells inducing graft-versus-host disease are single peptide specific

scientific article published on 4 October 2011

Aminopeptidase‐Resistant Peptides Are Targeted to Lysosomes and Subsequently Degraded ⬇️

scientific article published on September 19, 2011

An HLA class II restricted T-cell is able to recognize about a million different peptides

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases

scientific article published on 01 November 2008

An ensemble of rapidly interconverting orientations in electrostatic protein-peptide complexes characterized by NMR spectroscopy.

scientific article published on 6 February 2014

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

scientific article published on 15 January 2018

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles.

scientific article published on 17 February 2012

Antigen microarray profiling of autoantibodies in rheumatoid arthritis.

scientific article published in September 2005

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

article

Antimicrobial Peptides in Biomedical Device Manufacturing.

scientific article published on 24 August 2017

Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping

scientific article published on 19 November 2015

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes

scientific article

Bactericidal activity of amphipathic cationic antimicrobial peptides involves altering the membrane fluidity when interacting with the phospholipid bilayer

scientific article published on 11 June 2018

CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cells

scientific article published on 15 November 2007

CD8 T-cell recognition of human 5T4 oncofetal antigen.

scientific article

CTLs are targeted to kill ? cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

scientific article published in September 2009

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

scientific article published on October 2008

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

article published in 2009

Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies

scientific article published on 28 October 2013

Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals.

scientific article published on 22 May 2013

Clostridium difficilesortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation

scientific article published on 23 October 2014

Competition-based cellular peptide binding assay for HLA class I.

scientific article published on September 2004

Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides

scientific article published on February 2003

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

scientific article

DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge

scientific article published on November 2013

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype

scholarly article

Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.

scientific article published on 4 March 2016

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

scientific article published on 5 August 2013

Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule

scientific article published on 03 December 2009

Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment

scientific article published in July 2005

Development of a Nose Cream Containing the Synthetic Antimicrobial Peptide P60.4Ac for Eradication of Methicillin-Resistant Staphylococcus aureus Carriage ⬇️

scientific article published on August 17, 2013

Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application

scientific article published on 7 November 2005

Discovery of T cell epitopes implementing HLA-peptidomics into a reverse immunology approach.

scientific article published on 8 March 2013

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.

scientific article published on 30 December 2015

Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family

scientific article published in Journal of Biological Chemistry

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

scientific article published on 26 April 2007

Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule

scientific article published on 27 June 2008

Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

scientific article published on 30 August 2011

Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer

scientific article published on 07 February 2014

Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells.

scientific article published on 19 October 2017

Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice

scientific article

Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays

scientific article published on 28 April 2010

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes

scientific article published on 09 January 2019

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

scientific article published on 6 May 2010

Evaluation of Sibling and Twin Fragment Ions Improves the Structural Characterization of Proteins by Top-Down MALDI In-Source Decay Mass Spectrometry

scientific article published on 02 April 2020

Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses

scientific article published on October 2010

Expression, purification, and in vitro activity of an arterivirus main proteinase

scientific article published on 9 March 2006

Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome

scientific article published on 01 October 2008

Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer

scientific article

High Number of Intraepithelial CD8+Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

scientific article published on 01 January 2007

High resolution mass spectrometry for rapid characterization of combinatorial peptide libraries

scientific article

Humoral responses to HIVconsv induced by heterologous vaccine modalities in rhesus macaques

scientific article published on 11 March 2015

Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis

scientific article published on 10 March 2017

Identification of citrullinated vimentin peptides as T cell epitopes in HLAâ DR4â positive patients with rheumatoid arthritis

scientific article published on 01 January 2010

Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4).

scientific article published on 17 February 2009

Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial

scientific article published in November 2009

Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation

scientific article published on 15 November 2007

Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance

scientific article published in November 2017

Induction of A. fumigatus-specific CD4-positive T cells in patients recovering from invasive aspergillosis

scientific article

Induction of HLA-A2 restricted CD8 T cell responses against ApoB100 peptides does not affect atherosclerosis in a humanized mouse model

scientific article published on 22 November 2019

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

scientific article published on 01 January 2008

Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer

scientific article published on 01 February 2009

LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature

scientific article published on 07 July 2010

LL-37-derived peptides eradicate multidrug-resistant Staphylococcus aureus from thermally wounded human skin equivalents

scientific article

Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains

scientific article

Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses

scientific article published on 22 November 2017

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

scientific article

Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.

scientific article

Mass-spectrometric identification of carbamylated proteins present in the joints of rheumatoid arthritis patients and controls

scientific article published on 01 September 2020

Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro

scientific article published on 25 January 2007

Metrological traceability in mass spectrometry-based targeted protein quantitation: a proof-of-principle study for serum apolipoproteins A-I and B100

scientific article published on 25 June 2014

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

scientific article

Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements

scientific article

Naturally processed non-canonical HLA-A*02:01 presented peptides

scientific article

New chelation strategy allows for quick and clean 99mTc-labeling of synthetic peptides.

scientific article

Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media

scientific article published on 14 April 2020

PS13 - 66. The type 1 diabetes associated HLA-DQ8-transdimer accommodates a unique islet peptide repertoire

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

article

Phospholipid-driven differences determine the action of the synthetic antimicrobial peptide OP-145 on Gram-positive bacterial and mammalian membrane model systems

scientific article published on 23 July 2015

Photochemical internalization enhances cytosolic release of antibiotic and increases its efficacy against staphylococcal infection

scientific article published on 05 June 2018

Positively charged amino acids flanking a sumoylation consensus tetramer on the 110kDa tri-snRNP component SART1 enhance sumoylation efficiency

scientific article

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

scientific article published on 02 October 2013

Potential factors contributing to the poor antimicrobial efficacy of SAAP-148 in a rat wound infection model

scientific article published on 03 December 2019

Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study

scientific article published on 31 January 2012

Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques

article

Production and Thermal Exchange of Conditional Peptide-MHC I Multimers

scientific article published on 01 September 2019

Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines

scientific article

Quantifying protein measurands by peptide measurements: where do errors arise?

scientific article published on 6 January 2015

Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases

scholarly article by Hoebert S. Hiemstra et al published August 1999 in European Journal of Immunology

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

scientific article

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models

scientific article published on 23 April 2013

Sexual transmission of single human immunodeficiency virus type 1 virions encoding highly polymorphic multisite cytotoxic T-lymphocyte escape variants

scientific article

Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia

scientific article published on 01 July 2008

Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell Autoimmunity toward Pigmented Cells by Tyrosinase Haptenation and Melanosome Autophagy

scientific article published on 17 February 2011

Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase.

scientific article

Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele

scientific article

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

scientific article

Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

scientific article

Synergistic Microbicidal Effect of Cationic Antimicrobial Peptides and Teicoplanin against Planktonic and Biofilm-Encased Staphylococcus aureus

scientific article published on 10 October 2018

Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines

scientific article published on 11 April 2006

Synthesis of modified and hybrid protein derived biopolymers.

scientific article published in January 2009

Synthetic antimicrobial peptides delocalize membrane bound proteins thereby inducing a cell envelope stress response

scientific article published on 09 June 2018

T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy

scientific article published on 12 July 2011

T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease

scientific article

The Antifungal Plant Defensin HsAFP1 Is a Phosphatidic Acid-Interacting Peptide Inducing Membrane Permeabilization.

scientific article published on 21 November 2017

The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease.

scientific article

The Human Lactoferrin-Derived Peptide hLF1-11 Exerts Immunomodulatory Effects by Specific Inhibition of Myeloperoxidase Activity

scientific article published on 20 April 2012

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

scientific article published in January 2018

The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations

scientific article published on 13 March 2013

The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities.

scientific article published on 2 March 2014

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

scientific journal article

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

scientific article

The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle

scientific article

Thrombocidin-1-derived antimicrobial peptide TC19 combats superficial multi-drug resistant bacterial wound infections

scientific article published on 03 May 2020

Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire

scientific article

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection

scientific article

Unravelling the T-cell-mediated autoimmune attack on CNS myelin in a new primate EAE model induced with MOG34-56 peptide in incomplete adjuvant

scientific article published on 2 December 2011

Validation of a New Enzyme-Linked Immunosorbent Assay to Detect the Triggering Proteins and Peptides for Celiac Disease: Interlaboratory Study ⬇️

scientific article published on 01 January 2012

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