List of works - Rainer Landgraf

15N metabolic labeling: Evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times

article

A hypomorphic vasopressin allele prevents anxiety-related behavior

scientific article

A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment.

scientific article

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice

scientific article published on 28 April 2014

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

scientific article published on November 2003

Abnormal fluid homeostasis in apelin receptor knockout mice

scientific article published on 03 July 2009

Adult neurogenesis in a psychopathological mouse model of trait anxiety and comorbid depression-like behavior: effect of antidepressants.

scientific article published on 12 November 2009

Advances in vasopressin and oxytocin--from genes to behaviour to disease. Preface

scientific article published in January 2008

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

scientific article

Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior

scientific article

Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior

scientific article

Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin

scientific journal article

Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety

scientific article

Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates.

scientific article

An intrinsic vasopressin system in the olfactory bulb is involved in social recognition

scientific article

Animal models of anxiety

scientific article published in June 2003

Anxiety and hippocampus volume in the rat.

scientific article published in May 2006

Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors ⬇️

scientific article published on September 11, 2012

Behavioral and neurobiological effects of deep brain stimulation in a mouse model of high anxiety- and depression-like behavior.

scientific article published on 16 January 2013

Behavioral extremes of trait anxiety in mice are characterized by distinct metabolic profiles.

scientific article published on 30 July 2014

Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior.

scientific article

Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I.

scientific article published on 28 August 2006

Chronic treatment with a selective neurokinin-1 receptor antagonist in a mouse model of trait anxiety and depression: focus on behaviour and neuropeptidergic mechanisms.

scientific article

Co-segregation of hyperactivity, active coping styles, and cognitive dysfunction in mice selectively bred for low levels of anxiety

scientific article

Cognitive performance in rats differing in their inborn anxiety

scientific article published in June 2002

Confinement to the open arm of the elevated-plus maze as anxiety paradigm: behavioral validation

scientific article published in June 2006

Connecting Anxiety and Genomic Copy Number Variation: A Genome-Wide Analysis in CD-1 Mice

scientific article

Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment

scientific article published on 24 May 2007

Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity

scientific article

Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.

scientific article published in November 2007

Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment

scientific article published in March 2005

Different patterns of respiration in rat lines selectively bred for high or low anxiety

scientific article

Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety

scientific article

Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats ⬇️

scientific article published on December 23, 2010

Effects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat.

scientific article published on 27 July 2006

Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

scientific article published on 06 December 2013

Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - effects that are susceptible to antidepressants

scientific article published on 20 April 2020

Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions

scientific article (publication date: 28 February 2011)

Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions.

scientific article published on 16 November 2010

Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety.

scientific article published on 18 March 2014

Epigenetic Mechanisms Within the Cingulate Cortex Regulate Innate Anxiety-Like Behavior

scientific article published on 01 April 2019

Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats

scientific article published in January 2002

GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus.

scientific article published on February 2004

Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein

scientific article

Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat

scientific article published in February 2006

Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD.

scientific article

HAB/LAB rats: an animal model of extremes in trait anxiety and depression

scientific article published on 24 November 2003

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats

scientific article

High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety

scientific article

Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis.

scientific article

Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.

scientific article

Impaired extinction of learned fear in rats selectively bred for high anxiety--evidence of altered neuronal processing in prefrontal-amygdala pathways

scientific article

Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety.

scientific article published on September 2004

Inborn vs. acquired anxiety in cross-breeding and cross-fostering HAB/LAB mice bred for extremes in anxiety-related behavior

scientific article published on 01 February 2019

Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice

scientific article published on 08 April 2013

Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety

scientific article published on 9 May 2012

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism

scientific article

Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites

scientific article published in July 2002

Intranasally Administered Neuropeptide S (NPS) Exerts Anxiolytic Effects Following Internalization Into NPS Receptor-Expressing Neurons ⬇️

scientific article published on January 25, 2012

Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one.

scientific article published on April 2015

Listening to neuropeptides by microdialysis: echoes and new sounds?

scientific article published on April 2008

Low vagally-mediated heart rate variability and increased susceptibility to ventricular arrhythmias in rats bred for high anxiety.

scientific article published on 8 February 2014

Maternal care differs in mice bred for high vs. low trait anxiety: impact of brain vasopressin and cross-fostering

scientific article

Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole

scientific article

Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain

scientific article published on 20 March 2010

Mice selected for high versus low stress reactivity: a new animal model for affective disorders

scientific article published on 23 May 2008

Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats.

scientific article published on April 2004

Neurobiological correlates of successful deep brain stimulation in a mouse model of high trait affect.

scientific article

Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles

scientific article published in January 2005

Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex

scientific article published on 10 January 2018

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice

scientific article (publication date: 2011)

Protein biomarkers in a mouse model of extremes in trait anxiety

scientific article published on 14 June 2006

Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways

scientific article published on 23 August 2011

Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways

scientific article

Real-time imaging of amygdalar network dynamics in vitro reveals a neurophysiological link to behavior in a mouse model of extremes in trait anxiety

scientific article published in October 2013

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

scientific article

Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.

scientific article published on 25 July 2002

Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones.

scientific article published on 24 February 2005

Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis.

scientific article published in October 2002

Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression

scientific article

Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

scientific article published on March 2015

Sleep Phenotyping in a Mouse Model of Extreme Trait Anxiety ⬇️

scientific article published on July 11, 2012

Sleep disturbances in highly stress reactive mice: Modeling endophenotypes of major depression ⬇️

scientific article published on March 24, 2011

Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies

scientific article

Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans

scientific article published on 12 August 2002

Taurine regulates corticotropin secretion at the level of the supraoptic nucleus during stress in rats

scientific article published in September 2003

Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress

scientific article

The (15)N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model

scientific article published on 19 July 2012

The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety

scientific article published in July 2002

The clinical implications of mouse models of enhanced anxiety.

scientific article

The effect of treatment with ketoconazole on central CRH systems of depressed patients ⬇️

scientific article published on January 1, 2011

The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety

scientific article

The galanin system in depression and antidepressant treatment: focus on the locus coeruleus

The glycolytic metabolite methylglyoxal induces changes in vigilance by generating low-amplitude non-REM sleep

scientific article

The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited

scientific article

The involvement of the vasopressin system in stress-related disorders

scientific article

The vasopressin system--from antidiuresis to psychopathology

scientific article published on 19 January 2008

Tracking oxytocin functions in the rodent brain during the last 30 years: From push-pull perfusion to chemogenetic silencing

scientific article published on 11 March 2019

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects

scientific article

Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.

scientific article published on July 2010

Vasopressin administration into the paraventricular nucleus normalizes plasma oxytocin and corticosterone levels in Brattleboro rats

scientific journal article

Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage.

scientific article published on 3 January 2014

Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication

scientific article

Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion.

scientific article published in August 2002

Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results

scientific article

Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders.

scientific article

Vasopressin signaling at brain level controls stress hormone release: the vasopressin-deficient Brattleboro rat as a model

scientific article published on 23 June 2015

Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour

scientific journal article

List of works by Rainer Landgraf

15N metabolic labeling: Evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times

A hypomorphic vasopressin allele prevents anxiety-related behavior

A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment.

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

Abnormal fluid homeostasis in apelin receptor knockout mice

Adult neurogenesis in a psychopathological mouse model of trait anxiety and comorbid depression-like behavior: effect of antidepressants.

Advances in vasopressin and oxytocin--from genes to behaviour to disease. Preface

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior

Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior

Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin

Altered brain activation pattern associated with drug-induced attenuation of enhanced depression-like behavior in rats bred for high anxiety

Altered hypothalamo-pituitary-adrenal and sympatho-adrenomedullary activities in rats bred for high anxiety: central and peripheral correlates.

An intrinsic vasopressin system in the olfactory bulb is involved in social recognition

Animal models of anxiety

Anxiety and hippocampus volume in the rat.

Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors ⬇️

Behavioral and neurobiological effects of deep brain stimulation in a mouse model of high anxiety- and depression-like behavior.

Behavioral extremes of trait anxiety in mice are characterized by distinct metabolic profiles.

Blunted HPA axis reactivity reveals glucocorticoid system dysbalance in a mouse model of high anxiety-related behavior.

Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I.

Chronic treatment with a selective neurokinin-1 receptor antagonist in a mouse model of trait anxiety and depression: focus on behaviour and neuropeptidergic mechanisms.

Co-segregation of hyperactivity, active coping styles, and cognitive dysfunction in mice selectively bred for low levels of anxiety

Cognitive performance in rats differing in their inborn anxiety

Confinement to the open arm of the elevated-plus maze as anxiety paradigm: behavioral validation

Connecting Anxiety and Genomic Copy Number Variation: A Genome-Wide Analysis in CD-1 Mice

Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment

Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity

Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.

Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment

Different patterns of respiration in rat lines selectively bred for high or low anxiety

Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety

Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats ⬇️

Effects of Morris water maze testing on the neuroendocrine stress response and intrahypothalamic release of vasopressin and oxytocin in the rat.

Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - effects that are susceptible to antidepressants

Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions

Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions.

Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety.

Epigenetic Mechanisms Within the Cingulate Cortex Regulate Innate Anxiety-Like Behavior

Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats

GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus.

Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein

Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat

Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD.

HAB/LAB rats: an animal model of extremes in trait anxiety and depression

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats

High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety

Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis.

Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.

Impaired extinction of learned fear in rats selectively bred for high anxiety--evidence of altered neuronal processing in prefrontal-amygdala pathways

Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety.

Inborn vs. acquired anxiety in cross-breeding and cross-fostering HAB/LAB mice bred for extremes in anxiety-related behavior

Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice

Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism

Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites

Intranasally Administered Neuropeptide S (NPS) Exerts Anxiolytic Effects Following Internalization Into NPS Receptor-Expressing Neurons ⬇️

Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one.

Listening to neuropeptides by microdialysis: echoes and new sounds?

Low vagally-mediated heart rate variability and increased susceptibility to ventricular arrhythmias in rats bred for high anxiety.

Maternal care differs in mice bred for high vs. low trait anxiety: impact of brain vasopressin and cross-fostering

Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole

Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain

Mice selected for high versus low stress reactivity: a new animal model for affective disorders

Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats.

Neurobiological correlates of successful deep brain stimulation in a mouse model of high trait affect.

Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles

Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice

Protein biomarkers in a mouse model of extremes in trait anxiety

Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways

Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways

Real-time imaging of amygdalar network dynamics in vitro reveals a neurophysiological link to behavior in a mouse model of extremes in trait anxiety

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.

Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones.

Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis.