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List of works by Ilsa Coleman

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models.

scientific article published on 4 July 2018

A causal role for ERG in neoplastic transformation of prostate epithelium.

scholarly article

A comparison of prostate cancer cell transcriptomes in 2D monoculture vs 3D xenografts identify consistent gene expression alterations associated with tumor microenvironments

scientific article published on 18 February 2020

A molecular correlate to the Gleason grading system for prostate adenocarcinoma

scholarly article

A three-marker FISH panel detects more genetic aberrations of AR, PTEN and TMPRSS2/ERG in castration-resistant or metastatic prostate cancers than in primary prostate tumors

scientific article

AR variant ARv567es induces carcinogenesis in a novel transgenic mouse model of prostate cancer

scientific article

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

scientific article published on 14 February 2019

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

scientific article published on 11 May 2020

An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer

scientific article published on November 2007

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

scientific article published on June 2017

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling

scientific article

Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.

scientific article published on October 2011

Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation

scientific article

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

scientific article published on 26 November 2018

Cabozantinib can block growth of neuroendocrine prostate cancer patient-derived xenografts by disrupting tumor vasculature

scientific article published on 20 January 2021

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

scientific article

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations

scientific article published on 11 January 2016

Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy

scientific article published on 19 June 2015

Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts

scientific article published on 19 December 2016

Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma ⬇️

scientific article published in May 2005

Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases ⬇️

scientific article published on January 17, 2013

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

scientific article published on October 2014

Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer

scientific article

Chemotherapy-induced monoamine oxidase expression in prostate carcinoma functions as a cytoprotective resistance enzyme and associates with clinical outcomes

scientific article

Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis

scientific article

Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors

scientific article published on 20 December 2016

Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

scientific article published on 01 May 2020

Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors

scientific article published in October 2006

Comparative analyses of chromosome alterations in soft-tissue metastases within and across patients with castration-resistant prostate cancer

scientific article published on 22 September 2009

Comparison of four next generation sequencing platforms for fusion detection: Oncomine by ThermoFisher, AmpliSeq by illumina, FusionPlex by ArcherDX, and QIAseq by QIAGEN

scientific article published on 07 March 2020

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

scientific article

Conserved gene expression programs integrate mammalian prostate development and tumorigenesis

scientific article published on 17 February 2009

Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate

scientific article

DNA Damage Induces a Secretory Program in the Quiescent TME that Fosters Adverse Cancer Phenotypes

scientific article published on 29 March 2017

DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance.

scientific article

Differential expression of angiogenesis associated genes in prostate cancer bone, liver and lymph node metastases

scientific article published on 31 October 2007

Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect

scientific article

Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts

scientific article published on 19 June 2019

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors.

scientific article published on June 2015

EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis

scientific article published on 05 February 2019

Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases

scientific article

Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers

scientific article

Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer

scientific article published on 15 November 2019

Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155.

scientific article published in May 2017

Expression of STAT3 in Prostate Cancer Metastases.

scientific article published on 22 June 2016

Expression of cell cycle-regulated genes and prostate cancer prognosis in a population-based cohort

scientific article (publication date: September 2015)

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo

scientific article published on 23 February 2006

Gene expression panel predicts metastatic-lethal prostate cancer outcomes in men diagnosed with clinically localized prostate cancer

scientific article published on 19 October 2016

Genetic background influences murine prostate gene expression: implications for cancer phenotypes

scientific article published on January 2007

Genomic correlates of clinical outcome in advanced prostate cancer.

scientific article

HE3235 inhibits growth of castration-resistant prostate cancer

scientific article

Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer

scientific article published on 05 December 2019

Imaging Fibroblast Activation Protein Alpha improves diagnosis of metastatic Prostate Cancer with Positron Emission Tomography

scientific article published on 07 July 2020

Influence of surgical manipulation on prostate gene expression: implications for molecular correlates of treatment effects and disease prognosis

scientific article

Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279.

scientific article published in July 2017

Inhibition of androgen-independent prostate cancer by estrogenic compounds is associated with increased expression of immune-related genes

scientific article

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

scientific article published on 03 March 2021

Interaction of IGF signaling and the androgen receptor in prostate cancer progression

scientific article

Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer

scientific article published on 01 May 2007

Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma

scientific article

Low-fat, low-glycemic load diet and gene expression in human prostate epithelium: a feasibility study of using cDNA microarrays to assess the response to dietary intervention in target tissues

scientific article

LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an--d Serve as Models for Evaluating Cancer Therapeutics.

scientific article published on 3 February 2017

Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases.

scientific article

Mismatch repair enzyme expression in primary and castrate resistant prostate cancer

scientific article published on 12 September 2016

Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment

scientific article

Molecular determinants of response to high-dose androgen therapy in prostate cancer

scientific article published on 03 October 2019

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

scientific article published on 30 July 2019

Multiplexed functional genomic analysis of 5' untranslated region mutations across the spectrum of prostate cancer

scientific article published on 09 July 2021

Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer

scientific article published on 30 August 2017

PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer

scientific article published on 17 September 2019

PPP2R2C Loss Promotes Castration-Resistance and Is Associated with Increased Prostate Cancer-Specific Mortality ⬇️

scientific article published on March 14, 2013

Prostate cancer derived prostatic acid phosphatase promotes an osteoblastic response in the bone microenvironment

scientific article

Prostate cancer-associated gene expression alterations determined from needle biopsies

scientific article

Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer

scientific article

Publisher Correction: The long tail of oncogenic drivers in prostate cancer

scientific article published on 01 July 2019

Regulation of CEACAM5 and therapeutic efficacy of an anti-CEACAM5-SN38 antibody-drug conjugate in neuroendocrine prostate cancer

scientific article published on 16 November 2020

Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression

scientific article

Regulation of hepatocyte activator inhibitor-1 expression by androgen and oncogenic transformation in the prostate

scientific article

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

scientific article published on 30 March 2021

Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors

scientific article published on 28 September 2020

SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer

scientific article

Single cell transcriptomic analysis of prostate cancer cells ⬇️

scientific article published on February 16, 2013

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.

scientific article published on 12 February 2016

Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype

scientific article

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

scientific article published on 29 February 2016

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

scientific article published on 01 October 2021

Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage

scientific article published on 16 July 2019

Targeting RET Kinase in Neuroendocrine Prostate Cancer

scientific article published on 27 May 2020

The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells

scientific article published on 17 September 2018

The androgen receptor regulates a druggable translational regulon in advanced prostate cancer

scientific article published on 01 July 2019

The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

scientific article

The effects of aging on the molecular and cellular composition of the prostate microenvironment

scientific article

The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells

scientific article

The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms

scientific article published in January 2006

The long tail of oncogenic drivers in prostate cancer.

scientific article published on 2 April 2018

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression ⬇️

scientific article published on November 22, 2010

Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression.

scientific article published on September 2007

Transforming Growth Factor-{beta}-Stimulated Clone-22 Is an Androgen-Regulated Gene That Enhances Apoptosis in Prostate Cancer following Insulin-Like Growth Factor-I Receptor Inhibition

scientific article published on December 2009

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.

scientific article

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer.

scientific article

VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer

scientific article

Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition: implications for prostate cancer chemoprevention

scientific article

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