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List of works by Ram Sasisekharan

A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets ⬇️

scientific article published on March 2, 2011

A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza

scientific article

A broadly neutralizing human monoclonal antibody is effective against H7N9.

scientific article

A dual-color fluorescence imaging-based system for the dissection of antiangiogenic and chemotherapeutic activity of molecules

scientific article

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

scientific article

Advancing glycomics: implementation strategies at the consortium for functional glycomics

scientific article

An inter-residue network model to identify mutational-constrained regions on the Ebola coat glycoprotein

scientific article published on 11 April 2017

Antibody-Based Strategies to Prevent and Treat Influenza

scientific article (publication date: 2015)

Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic ⬇️

scientific article published on January 1, 2013

Atomic interaction networks in the core of protein domains and their native folds

scientific article

Biochemical characterization of the chondroitinase B active site

scientific article (publication date: 23 August 2002)

Biologically active decorin is a monomer in solution.

scientific article published on 3 December 2003

Broadly neutralizing influenza hemagglutinin stem-specific antibody CR8020 targets residues that are prone to escape due to host selection pressure

scientific article

Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D.

scientific article

Competitive Inhibition of Heparinase by Persulfonated Glycosaminoglycans: A Tool to Detect Heparin Contamination ⬇️

scientific article published on September 19, 2011

Contaminated heparin associated with adverse clinical events and activation of the contact system

scientific article

Context-specific target definition in influenza a virus hemagglutinin-glycan receptor interactions

scientific article published on August 2009

Correction: Quantitative Description of Glycan-Receptor Binding of Influenza A Virus H7 Hemagglutinin.

scientific article published on 30 December 2013

Corrigendum to: “Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets” [Virology 446 (1–2) (2013) 349–356]

scientific article published in December 2015

Crystal structure of heparinase II from Pedobacter heparinus and its complex with a disaccharide product

scientific article

Decoding the Distribution of Glycan Receptors for Human-Adapted Influenza A Viruses in Ferret Respiratory Tract ⬇️

scientific article published on February 16, 2012

Determinants of glycan receptor specificity of H2N2 influenza A virus hemagglutinin

scientific article

Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus

scientific article published on 22 September 2011

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses ⬇️

scientific article published on March 23, 2011

Emerging views of heparan sulfate glycosaminoglycan structure/activity relationships modulating dynamic biological functions

scientific article

Extrapolating from sequence--the 2009 H1N1 'swine' influenza virus

scientific article (publication date: June 2009)

Glycan Receptor Binding of the Influenza A Virus H7N9 Hemagglutinin ⬇️

scientific article published on 06 June 2013

Glycan array data management at Consortium for Functional Glycomics

scientific article

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus

scientific article

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

scientific article published on 6 January 2008

Glycan-protein interactions in viral pathogenesis

scientific article

Glycans as receptors for influenza pathogenesis ⬇️

scientific article published on August 24, 2010

Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay

scientific article

Glycomics: an integrated systems approach to structure-function relationships of glycans

scientific article

Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors.

scientific article

HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo

scientific article

Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift

scientific article

Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air.

scientific article

Influenza surveillance: 2014-2015 H1N1 "swine"-derived influenza viruses from India

scientific article

Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.

scientific article

Modified recombinant human erythropoietin with potentially reduced immunogenicity

scientific article published on 15 January 2021

Modular glycosphere assays for high-throughput functional characterization of influenza viruses

scientific article

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.

scientific article published on 31 May 2018

Monitoring of heparin and its low-molecular-weight analogs by silicon field effect.

scholarly article

N-Linked Glycosylation of the Hemagglutinin Protein Influences Virulence and Antigenicity of the 1918 Pandemic and Seasonal H1N1 Influenza A Viruses ⬇️

scientific article published on June 5, 2013

New England harbor seal H3N8 influenza virus retains avian-like receptor specificity

scientific article published on 18 February 2016

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

scientific article

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

scientific article

Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets ⬇️

scientific article published on February 21, 2012

Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death

scientific article

Prediction of the binding interface between monoclonal antibody m102.4 and Nipah attachment glycoprotein using structure-guided alanine scanning and computational docking

scientific article published on 26 October 2020

Quantitative Characterization of Glycan-Receptor Binding of H9N2 Influenza A Virus Hemagglutinin ⬇️

scientific article published on April 23, 2013

Quantitative Description of Glycan-Receptor Binding of Influenza A Virus H7 Hemagglutinin ⬇️

scientific article published on February 20, 2013

Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses.

scientific article

Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.

scientific article

Rational design of low-molecular weight heparins with improved in vivo activity

scientific article

Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957.

scientific article

Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets

scientific article

Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles ⬇️

scientific article published on May 22, 2013

Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

scientific article published on 8 April 2013

Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants

scientific article published on 11 November 2015

Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity

scientific article

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

scientific article

Targeting an antimicrobial effector function in insect immunity as a pest control strategy

scientific article (publication date: 4 August 2009)

The impact of heparanese and heparin on cancer metastasis and angiogenesis

scientific article

The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation

scientific article published on 10 August 2010

The soft palate is an important site of adaptation for transmissible influenza viruses

scientific article

The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery

scientific article

Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis

scientific article

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