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List of works by Marc Wirden

Antiretroviral combinations implicated in emergence of the L74I and L74V resistance mutations in HIV-1-infected patients

scientific article

Association of Gag cleavage sites to protease mutations and to virological response in HIV-1 treated patients

scientific article published on 26 July 2006

Clinically relevant interpretation of genotype and relationship to plasma drug concentrations for resistance to saquinavir-ritonavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients

scientific article

Clonal analyses of HIV quasispecies in patients harbouring plasma genotype with K65R mutation associated with thymidine analogue mutations or L74V substitution

scientific article published in March 2005

Combination of two pathways involved in raltegravir resistance confers dolutegravir resistance

scientific article published on 23 July 2015

Comparison of the dynamics of resistance-associated mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors after cessation of antiretroviral combination therapy.

scientific article

Differential impact of APOBEC3-driven mutagenesis on HIV evolution in diverse anatomical compartments

scientific article published on February 2014

E138K and M184I mutations in HIV-1 reverse transcriptase coemerge as a result of APOBEC3 editing in the absence of drug exposure

scientific article published in August 2012

E17A mutation in HIV-1 Vpr confers resistance to didanosine in association with thymidine analog mutations

scientific article published on 25 November 2011

Factors associated with proviral DNA HIV-1 tropism in antiretroviral therapy-treated patients with fully suppressed plasma HIV viral load: implications for the clinical use of CCR5 antagonists

scientific article

Factors associated with the selection of mutations conferring resistance to protease inhibitors (PIs) in PI-experienced patients displaying treatment failure on darunavir

scientific article

Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients

scientific article

Highly multidrug-resistant HIV: clonal analysis and therapeutic strategies

scientific article published on 19 July 2013

Historical HIV-RNA resistance test results are more informative than proviral DNA genotyping in cases of suppressed or residual viraemia

scientific article published on 26 January 2011

INSTI-Based Triple Regimens in Treatment-Naïve HIV-Infected Patients Are Associated With HIV-RNA Viral Load Suppression at Ultralow Levels

article

Identification of a rare mutation at reverse transcriptase Lys65 (K65E) in HIV-1-infected patients failing on nucleos(t)ide reverse transcriptase inhibitors

scientific article published on 7 June 2013

Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease

scientific article published in September 2008

Improved detection of resistance at failure to a tenofovir, emtricitabine and efavirenz regimen by ultradeep sequencing

scientific article published on 21 January 2015

Interruption of nonnucleoside reverse transcriptase inhibitor (NNRTI) therapy for 2 months has no effect on levels of human immunodeficiency virus type 1 in plasma of patients harboring viruses with mutations associated with resistance to NNRTIs

scientific article

Less frequent follow-up in routine care than in trials does not impact resistance selection in patients failing DRV/r or ATV/r first line treatment

scientific article published on 2 November 2014

Low frequency of HIV-1 tropism evolution in patients successfully treated for at least 2 years

article

Low-level HIV-1 viraemia in patients on HAART: risk factors and management in clinical practice

scientific article published on 28 April 2015

Multicenter comparison of the new Cobas 6800 system with Cobas Ampliprep/Cobas TaqMan and Abbott RealTime for the quantification of HIV, HBV and HCV viral load

scientific article published on 20 September 2017

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

scientific article published on 28 January 2008

National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011.

scientific article

New HIV-1 circulating recombinant form 94: from phylogenetic detection of a large transmission cluster to prevention in the age of geosocial-networking apps in France, 2013 to 2017

scientific article published on 01 September 2019

New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T)

scientific article published on 27 November 2018

Partially active HIV-1 Vif alleles facilitate viral escape from specific antiretrovirals

scientific article published on September 2010

Positive impact of HIV-1 gag cleavage site mutations on the virological response to darunavir boosted with ritonavir

scientific article published on 31 January 2011

Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL in 2009: a French nationwide study

scientific article published on 12 February 2013

Prevalence of resistance mutations related to integrase inhibitor S/GSK1349572 in HIV-1 subtype B raltegravir-naive and -treated patients

article

Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients

scientific article published in April 2007

Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients

scientific article published on 16 February 2009

Raltegravir has no residual antiviral activity in vivo against HIV-1 with resistance-associated mutations to this drug

scientific article published on 27 August 2009

Resistance mutations before and after tenofovir regimen failure in HIV-1 infected patients

scientific article published in July 2005

Resistance profiles observed in virological failures after 24 weeks of amprenavir/ritonavir containing regimen in protease inhibitor experienced patients

scientific article published in September 2004

Resistance-associated mutations to etravirine (TMC-125) in antiretroviral-naïve patients infected with non-B HIV-1 subtypes

scientific article published on 14 December 2009

Risk factors for selection of the L74I reverse transcriptase mutation in human immunodeficiency virus type 1-infected patients

scientific article published on July 2006

Role of HIV-1 minority populations on resistance mutational pattern evolution and susceptibility to protease inhibitors

scientific article published in January 2006

Similar evolution of cellular HIV-1 DNA level in darunavir/ritonavir monotherapy versus triple therapy in MONOI-ANRS136 trial over 96 weeks

scientific article

The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype.

scientific article published on 19 September 2011

Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure

scientific article published in January 2004

Ultradeep sequencing detection of the R263K integrase inhibitor drug resistance mutation

scientific article published on 14 January 2017

Very early ART resulting in the absence of HIV-1 antibodies and in a sustained undetectable plasma HIV-1-RNA and proviral-DNA in an HLA-B*5701 and Δ32 heterozygote HIV-1-infected patient was not associated with functional cure

scientific article published on 19 September 2014

Virologic outcome after switching from a nucleoside reverse transcriptase inhibitor to tenofovir in patients with undetectable HIV-1 RNA plasma level

scientific article

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