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List of works by Christiaan Leeuwenburgh

"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content

scientific article published on 9 September 2016

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

scientific article

A better understanding of why murine models of trauma do not recapitulate the human syndrome

scientific article

A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat.

scientific article

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

scientific article published in 2008

A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration

scientific article published in January 2006

Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults

scientific article

Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart

scientific article published on 17 December 2018

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle

scientific article published on 27 November 2019

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

scientific article

Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding.

scientific article published on 04 September 2012

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

scientific article published on 21 May 2008

Age-related cellular changes in the long-lived bivalve A. islandica

scientific article published on 29 August 2015

Age-related differences in apoptosis with disuse atrophy in soleus muscle

scientific journal article

Age-related differences in lower extremity tissue compartments and associations with physical function in older adults

scientific article published on 12 October 2011

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

scientific article

Aged mice are unable to mount an effective myeloid response to sepsis

scientific article published on 13 December 2013

Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver.

scientific article published on 13 September 2013

Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12

scientific article published on 01 January 2004

Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

scientific article published on 02 December 2020

Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase

scientific article published on 08 May 2007

Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review

scientific article published on 23 September 2011

Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease

scientific article published on 29 June 2019

Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice

scientific article published on August 18, 2011

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.

scientific article published on 18 January 2013

Autophagy in the liver: cell's cannibalism and beyond

scientific article

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

scientific article published on 14 December 2017

Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats

scientific article

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle

scientific article published on 27 October 2015

Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction.

scientific article published on 29 January 2009

Brown adipose tissue and the cold war against obesity

scientific article

Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility

scientific article published on December 2013

Caloric restriction in humans: potential pitfalls and health concerns

scientific article

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity

scientific article

Calorie restriction for optimal cardiovascular aging: the weight of evidence

scientific article

Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives

scientific article

Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction

scientific journal article

Changes in lipid distribution during aging and its modulation by calorie restriction

scientific article published on 11 March 2009

Chronic pain, perceived stress, and cellular aging: an exploratory study

scientific article published on 12 February 2012

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders.

scientific article published on 10 November 2017

Clinical Characteristics and Response to Supervised Exercise Therapy in People with Lower Extremity Peripheral Artery Disease

scientific article published on 13 May 2020

Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial

scientific article published on 14 February 2020

Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease

scientific article published on 23 December 2019

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

scientific article

Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities

scientific article

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice.

scientific article

Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease

scientific article published on 09 May 2020

Critical role of autophagy in ischemia/reperfusion injury to aged livers

scientific article published on January 1, 2012

Current nutritional recommendations and novel dietary strategies to manage sarcopenia

scientific article published on January 2013

Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults

scientific article published on 11 August 2017

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.

scientific article

Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.

scientific article published in August 2002

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging

scientific article

ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design

scientific article

Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial

scientific article published on 12 April 2017

Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial

article

Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.

scientific article

Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials.

scientific article

Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial

scientific article published on June 15, 2011

Effects of age and caloric restriction on brain neuronal cell death/survival

scientific article published in June 2004

Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men

scientific article

Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6

scientific article published on 01 March 2006

Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus

scientific article

Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats

scientific article published on 14 November 2007

Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice.

scientific article published on 21 November 2006

Exercise-Induced Autophagy in Fatty Liver Disease

scientific article published on 17 April 2017

Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation

scientific article published on 27 April 2017

Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.

scientific article

Fasting or caloric restriction for Healthy Aging

scientific article published on April 29, 2013

Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study

scientific article published on May 2006

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study

scientific article

HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock

scientific article published in PLoS ONE

Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise

scientific article published on 01 March 2006

Host responses to sepsis vary in different low-lethality murine models

scientific article

Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle

scientific article published on 18 July 2016

Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.

scientific article published on 13 October 2016

Impaired Iron Status in Aging Research

scientific article published on February 22, 2012

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart

scientific article published on 30 June 2018

Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects

scientific article published on 24 July 2015

Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

scientific journal article

Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity

scientific article published on 06 May 2009

Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney

scientific article published on March 3, 2011

Innovations in Geroscience to enhance mobility in older adults

scientific article published on 22 October 2020

Integrated control of brown adipose tissue

scientific article published on March 2016

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

scientific article published on 26 October 2016

Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study

scientific article published on November 1, 2011

Iron accumulation with age, oxidative stress and functional decline

scientific article

LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock

scientific article published on 18 September 2019

Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats

scientific article published on 01 January 2005

Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat.

scientific article published on 17 January 2008

Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial

scientific article published on 18 November 2020

Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans

scientific article published on August 2008

Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy.

scientific article

Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers

scientific article published on 17 May 2018

MEANINGFUL CHANGE IN SIX-MINUTE WALK IN PEOPLE WITH PERIPHERAL ARTERY DISEASE

scientific article published on 23 April 2020

Mitochondria and aging

scientific article published on 25 July 2011

Mitochondrial DNA mutations and apoptosis in mammalian aging.

scientific article published on August 2006

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice

scientific article

Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle

scientific article

Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy.

scientific article published on 18 May 2009

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

scientific article

Mitochondrial iron accumulation with age and functional consequences

scientific article published on October 2008

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.

scientific article published on March 2013

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

scientific article published on 01 September 2018

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

scientific article

Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise

scientific article published on 01 March 2006

Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults

scientific article published on 13 August 2008

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.

scientific article published on 31 May 2007

Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging

scientific article published on 23 February 2009

Molecular inflammation: underpinnings of aging and age-related diseases

scientific article published on 18 July 2008

Molecular mechanism of PPAR in the regulation of age-related inflammation

scientific article published on 19 January 2008

Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging

scientific article published on 19 February 2010

Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction

scientific article published on 21 January 2005

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis

scientific article published on 13 November 2019

Myeloperoxidase levels and mortality in frail community-living elderly individuals.

scientific article

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

scientific article published on August 1, 2010

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model

scientific article published on 01 November 2019

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival

scientific article published on 15 April 2020

Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach

scientific article

Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance

scientific article published on 08 May 2018

Persistent inflammation and anemia among critically ill septic patients

scientific article published on 01 February 2019

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery

scientific article published on 26 May 2018

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma

scientific article

Persistent injury-associated anemia and aging: Novel insights.

scientific article published in March 2018

Persistent injury-associated anemia in aged rats.

scientific article published on 4 January 2018

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery

scientific article published in October 2014

Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism

scientific article

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

scientific article published on 24 June 2019

Protective immunity and defects in the neonatal and elderly immune response to sepsis

scientific article published on 03 March 2014

Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial

scientific article published on 14 October 2020

Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial

scientific article published on 18 March 2017

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.

scientific article published on 07 June 2013

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study

scientific article

Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction

scientific article published on January 2009

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients

scientific article

Septic Stability? Gut Microbiota in Young Adult MICE Maintains Overall Stability After Sepsis Compared to Old Adult MICE

scientific article published on 20 August 2020

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals

scientific article published on June 7, 2013

Skeletal muscle apoptosis, sarcopenia and frailty at old age.

scientific article published on 18 October 2006

Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.

scientific article

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise

scientific article

Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults

scientific article published on 9 October 2012

Successful aging: Advancing the science of physical independence in older adults.

scientific article

Systemic inflammation, body composition, and physical performance in old community-dwellers.

scientific article published on 08 August 2016

Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise

scientific article published on 22 December 2018

The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods

scientific article published on 10 May 2018

The Effect of Aging Physiology on Critical Care

scientific article published on 28 October 2020

The Role of Genome Instability in Frailty: Mitochondria versus Nucleus

scientific article

The authors reply

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

scientific article published on 29 April 2010

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

scientific article

The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity

scientific article

The role of apoptosis in age-related skeletal muscle atrophy

scientific article

The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging

scientific article

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis

scientific article published on 02 November 2020

Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction

scientific article

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity

scientific article published on January 8, 2013

Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress

scientific article published on 17 August 2007

Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia

scientific article published on 2 June 2011

Vascular dysfunction as a potential culprit of sarcopenia

scientific article published on 26 December 2020

WITHDRAWN: Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors

retracted scientific article published on 26 September 2005