List of works - Clifford J Steer

A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.

scientific article published on 7 April 2005

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

scientific article

A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication

scientific article published on 13 November 2017

Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.

scientific article

Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation ⬇️

scientific article published on September 24, 2010

Bile acids: regulation of apoptosis by ursodeoxycholic acid

scientific article

Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines

scientific article

DNA methylation of Sleeping Beauty with transposition into the mouse genome

scientific article published in August 2005

Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes

scientific article published on 12 April 2007

Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation

scientific article published on October 2004

Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage.

scientific article

Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease

scientific article published on 18 May 2007

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells

scientific article

Evaluation of a new high-dimensional miRNA profiling platform

scientific article published on 27 August 2009

Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing

scientific article

Gene networks and microRNAs implicated in aggressive prostate cancer

scientific article published on December 2009

Gene repair and transposon-mediated gene therapy

scientific article

Gene repair in the new age of gene therapy

scientific article

Gene therapy and CVD: how near are we?

scientific article published on May 2004

Gene therapy as an alternative to liver transplantation

scientific article

Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines

scientific article

Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration

scientific article

Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease.

scientific article

High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene

scientific article

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

scientific article

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

scientific article

Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors

scientific article

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

scientific article published on 21 January 2016

In vivo application of non-viral vectors to the liver

scientific article

Liver-targeted gene therapy: Approaches and challenges

scientific article

Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon

scientific article

MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.

scientific article

MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis

scientific article

MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases

scientific article

Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.

scientific article

Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice

scientific article published on 08 June 2009

One Medicine One Science: a framework for exploring challenges at the intersection of animals, humans, and the environment

scientific article

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

scientific article

Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy

scientific article

Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models.

scientific article

Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217.

scientific article

Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria

scientific article

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans

scientific article

Site-specific base changes in the coding or promoter region of the human beta- and gamma-globin genes by single-stranded oligonucleotides

scientific article

Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion

scientific article published on 22 May 2006

Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference.

scientific article published on April 2005

Strategies for hepatic gene correction

scientific article

Synthesis and evaluation of water-soluble prodrugs of ursodeoxycholic acid (UDCA), an anti-apoptotic bile acid.

scientific article

Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway

scientific article

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

scientific article

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

scientific article

The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases

scientific article

The application of DNA repair vectors to gene therapy

scientific article

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

scientific article

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes ⬇️

scientific article

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

scientific article published on 20 May 2016

Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes

scientific article published on 26 September 2003

miR-34a regulates mouse neural stem cell differentiation

scientific article

miRNA expression in colon polyps provides evidence for a multihit model of colon cancer

scientific article published in 2011

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

scientific journal article

β-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model

scientific article

β‐globin matrix attachment region improves stable genomic expression of the Sleeping beauty transposon ⬇️

scientific article published on September 1, 2011

List of works by Clifford J Steer

A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication

Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.

Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation ⬇️

Bile acids: regulation of apoptosis by ursodeoxycholic acid

Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines

DNA methylation of Sleeping Beauty with transposition into the mouse genome

Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes

Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation

Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage.

Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells

Evaluation of a new high-dimensional miRNA profiling platform

Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing

Gene networks and microRNAs implicated in aggressive prostate cancer

Gene repair and transposon-mediated gene therapy

Gene repair in the new age of gene therapy

Gene therapy and CVD: how near are we?

Gene therapy as an alternative to liver transplantation

Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines

Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration

Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease.

High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

In vivo application of non-viral vectors to the liver

Liver-targeted gene therapy: Approaches and challenges

Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon

MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.

MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis

MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases

Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.

Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice

One Medicine One Science: a framework for exploring challenges at the intersection of animals, humans, and the environment

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy

Prevention of acute kidney injury by tauroursodeoxycholic acid in rat and cell culture models.

Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217.

Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans

Site-specific base changes in the coding or promoter region of the human beta- and gamma-globin genes by single-stranded oligonucleotides

Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion

Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference.

Strategies for hepatic gene correction

Synthesis and evaluation of water-soluble prodrugs of ursodeoxycholic acid (UDCA), an anti-apoptotic bile acid.

Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases

The application of DNA repair vectors to gene therapy

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes ⬇️

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes

miR-34a regulates mouse neural stem cell differentiation

miRNA expression in colon polyps provides evidence for a multihit model of colon cancer

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

β-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model

β‐globin matrix attachment region improves stable genomic expression of the Sleeping beauty transposon ⬇️