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List of works by David A Largaespada

A Comprehensive Guide to Sleeping Beauty-Based Somatic Transposon Mutagenesis in the Mouse

scientific article

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

scientific article

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

scientific article published on 11 May 2015

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.

scientific article

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

scientific article

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

scientific article

A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.

scientific article published on November 2002

A transposon and transposase system for human application

scientific article

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

scientific article

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

scientific article

Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

scientific article published on 7 November 2006

CADD-14. TARGETING THE CD200 CHECKPOINT FOR THE FIGHT AGAINST CENTRAL NERVOUS SYSTEM TUMORS

CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy

scientific article published on 17 October 2019

CRISPR/Cas9 library screening for drug target discovery

scientific article published on 20 November 2017

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

scientific article published on July 2005

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance

scientific article published on 27 March 2013

Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen.

scientific article

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.

scientific article

Comparative transcriptome analysis quantifies immune cell transcript levels, metastatic progression and survival in osteosarcoma.

scientific article published on 24 October 2017

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

scientific article published on 18 December 2012

Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon

scientific article published on 26 June 2006

Coping with cancer genes altered by copy number

scientific article published on November 2015

DNA methylation of Sleeping Beauty with transposition into the mouse genome

scientific article published in August 2005

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells

scientific article published on 02 October 2011

Engineered Swine Models of Cancer

scientific article

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

scientific article published on 13 June 2019

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy ⬇️

scientific article published on January 10, 2013

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

scientific article published on 19 May 2013

Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

scientific article published in September 2003

Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers

scientific article published on 3 August 2006

Gene transfer into genomes of human cells by the sleeping beauty transposon system.

scientific article

Generating and manipulating transgenic animals using transposable elements

scientific article

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice

scientific article (publication date: 2014)

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

scientific article published on 02 October 2018

Genetically modified mice in cancer research

scientific article

Harnessing a high cargo-capacity transposon for genetic applications in vertebrates

scientific article published on 28 August 2006

HomeRun Vector Assembly System: a flexible and standardized cloning system for assembly of multi-modular DNA constructs

scientific article

IMMU-23. TARGETING THE CD200 CHECKPOINT TO ENHANCE IMMUNOTHERAPY FOR CNS TUMORS

scientific article published on 23 April 2019

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

scientific article published in Scientific Reports

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis

scientific article

Implication of ZNF217 in accelerating tumor development and therapeutically targeting ZNF217-induced PI3K-AKT signaling for the treatment of metastatic osteosarcoma

scientific article published on 30 September 2020

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

scientific article published on 21 January 2016

Insertional mutagenesis in mice: new perspectives and tools

scientific article

MMuFLR: missense mutation and frameshift location reporter

scientific article published on 3 July 2013

MTID: a database of Sleeping Beauty transposon insertions in mice

scientific article published on January 2003

Mammalian germ-line transgenesis by transposition.

scientific article

Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system.

scientific article

Modular assembly of transposon integratable multigene vectors using RecWay assembly.

scientific article published on 26 February 2013

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies

scientific article

NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

scientific article

New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens

scientific article

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach

scientific article

PCM-15SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING.

scientific article

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

scientific article published on 03 April 2020

PM-05ARHGAP36 AS A NOVEL DRIVER IN HIGH-RISK HUMAN MEDULLOBLASTOMA.

scientific article published in November 2014

PTPS-02FOXR2: AN ONCOGENE IN MEDULLOBLASTOMA.

scientific article

PVT1 dependence in cancer with MYC copy-number increase.

scientific article published on 22 June 2014

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

scientific article published on 02 August 2016

Pluripotency of mesenchymal stem cells derived from adult marrow

scientific article (publication date: 4 July 2002)

R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers

scientific article published on 15 December 2020

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

scientific article published on 20 August 2016

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

scientific article

Retrotransposons: A new and credible source of inherited and somatically acquired hepatocellular carcinoma mutations ⬇️

scientific article published on May 9, 2013

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.

scientific article

Simple and efficient methods for enrichment and isolation of endonuclease modified cells

scientific article (publication date: 2014)

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma

scientific article published on 24 October 2018

Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery

scientific article published on February 2015

Sleeping Beauty-mediated transposition and long-term expression in vivo: use of the LoxP/Cre recombinase system to distinguish transposition-specific expression

scientific article published on 13 December 2005

Sleeping beauty transposon-mediated gene therapy for prolonged expression

scientific article

Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas

scientific article

Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.

scientific article published on 14 December 2016

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

scientific article published on 11 June 2015

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

scientific article

Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish

scientific article

Structure-based prediction of insertion-site preferences of transposons into chromosomes

scientific article

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

scientific article

TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data

scientific article

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

scientific article

Transcriptomic analysis of gene signatures associated with sickle pain.

scientific article published on 16 May 2017

Transposable elements and the dynamic somatic genome

scientific article (publication date: 2007)

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.

scientific article

Transposon Mutagenesis of the Mouse Germline ⬇️

scientific article published on September 1, 2003

Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma.

scientific article

Transposon mutagenesis in mice

scientific article

Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctions

scientific article

Transposon-mediated mutagenesis of somatic cells in the mouse for cancer gene identification

scientific article

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis

scientific article

Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia

scientific article

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

scientific article

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

scientific article published on 10 February 2016

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