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List of works by David A Largaespada

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Pluripotency of mesenchymal stem cells derived from adult marrow

scientific article (publication date: 4 July 2002)
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

scientific article
PVT1 dependence in cancer with MYC copy-number increase.

scientific article published on 22 June 2014
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

scientific article published on July 2005
Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

scientific article
Gene transfer into genomes of human cells by the sleeping beauty transposon system.

scientific article
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates

scientific article published on 28 August 2006
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

scientific article
Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

scientific article published on 02 August 2016
A transposon and transposase system for human application

scientific article
Mammalian germ-line transgenesis by transposition.

scientific article
Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

scientific article published on 11 May 2015
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

scientific article published on 19 May 2013
Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

scientific article published on 11 June 2015
Sleeping beauty transposon-mediated gene therapy for prolonged expression

scientific article
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

scientific article
Transposon Mutagenesis of the Mouse Germline

scientific article published on September 1, 2003
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers

scientific article published on 3 August 2006
Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system

scientific article published in September 2003
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

scientific article
Structure-based prediction of insertion-site preferences of transposons into chromosomes

scientific article
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

scientific article
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.

scientific article
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance

scientific article published on 27 March 2013
Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis

scientific article
Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.

scientific article
Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

scientific article published on January 10, 2013
Insertional mutagenesis in mice: new perspectives and tools

scientific article
TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data

scientific article
A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.

scientific article published on November 2002
Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas

scientific article
Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.

scientific article
Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.

scientific article
mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

scientific article published on February 11, 2016
Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system.

scientific article
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon

scientific article published on 26 June 2006
A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

scientific article
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach

scientific article
Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctions

scientific article
Trp53 Haploinsufficiency Modifies EGFR-Driven Peripheral Nerve Sheath Tumorigenesis

scientific article published on May 13, 2014
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

scientific article published on 18 December 2012
Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery

scientific article published on February 2015
Comparative transcriptome analysis quantifies immune cell transcript levels, metastatic progression and survival in osteosarcoma.

scientific article published on 24 October 2017
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

scientific article published on 7 November 2006
Simple and efficient methods for enrichment and isolation of endonuclease modified cells

scientific article (publication date: 2014)
Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish

scientific article
Sleeping Beauty-mediated transposition and long-term expression in vivo: use of the LoxP/Cre recombinase system to distinguish transposition-specific expression

scientific article published on 13 December 2005

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