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List of works by Edward K Geissler

A cell-based approach to the minimization of immunosuppression in renal transplantation

scientific article published on 10 July 2008

A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma

scientific article

AAV plasmid DNA simplifies liver-directed in vivo gene therapy: comparison of expression levels after plasmid DNA-, adeno-associated virus- and adenovirus-mediated liver transfection

scientific article published in October 2010

ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases

scientific article published on 07 March 2017

Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible.

scientific article published in January 2009

Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol

scientific article published on 3 May 2016

Allogeneic bone marrow transplantation restores liver function in Fah-knockout mice

scientific article

Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs ⬇️

scientific article published on September 28, 2012

Anti-BAFF Treatment Interferes With Humoral Responses in a Model of Renal Transplantation in Rats

scientific article published on 01 January 2020

Benefit of Kupffer cell modulation with glycine versus Kupffer cell depletion after liver transplantation in the rat: effects on postischemic reperfusion injury, apoptotic cell death graft regeneration and survival

scientific article published in September 2005

Bile duct regeneration and immune response by passenger lymphocytes signals biliary recovery versus complications after liver transplantation

scientific article published on 01 November 2017

Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy

scientific article published in March 2004

Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis.

scientific article

Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo

scientific article published on November 2007

C5aR1 governs Mreg migration, development and function

article

Calcineurin Inhibitor Free De Novo Immunosuppression in Liver Transplant Recipients With Pretransplant Renal Impairment: Results of a Pilot Study (PATRON07).

scientific article

Can Mycophenolic Acid-based Immunosuppression Benefit Liver Transplant Patients With HCC?

scientific article published on 01 May 2019

Cell therapy as a strategy to minimize maintenance immunosuppression in solid organ transplant recipients ⬇️

scientific article published on August 1, 2013

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

scientific article

Clinical management of patients receiving cell-based immunoregulatory therapy.

scientific article published on 04 April 2014

Conversion of Th17 into IL-17A(neg) regulatory T cells: a novel mechanism in prolonged allograft survival promoted by mesenchymal stem cell-supported minimized immunosuppressive therapy

scientific article published on 10 October 2014

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

scientific article published on 29 July 2011

DHRS9 is a Stable Marker of Human Regulatory Macrophages

scientific article

DX5+ NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1

scientific article published on 01 May 2006

DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice ⬇️

scientific article published on April 29, 2011

Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo.

scientific article

Development of de novo cancer in p53 knock-out mice is dependent on the type of long-term immunosuppression used

scientific article published on 01 September 2006

Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas

scientific article published on 11 December 2012

Differential effects of heat-inactivated, secretome-deficient MSC and metabolically active MSC in sepsis and allogenic heart transplantation

scientific article published on 26 February 2020

Donor-specific Anti-HLA Antibodies Present in Pooled Human Serum Do Not Prevent Development of Human Mreg_UKR From Monocytes in Culture

scientific article published on 01 May 2017

Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer.

scientific article

Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

scientific article

Early Enrichment and Restitution of the Peripheral Blood Treg Pool Is Associated With Rejection-Free Stable Immunosuppression After Liver Transplantation

scientific article published in July 2016

Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells.

scientific article

European Reflections on New Indications for Extracorporeal Photopheresis in Solid Organ Transplantation.

scientific article published on 17 April 2018

Evidence-based medicine in daily surgical decision making: a survey-based comparison between the UK and Germany

scientific article published on 09 October 2014

Extended Pancreas Donor Program - The EXPAND Study A prospective multicenter trial testing the use of pancreas donors over age 50.

scientific article published on 5 February 2018

Extended pancreas donor program - the EXPAND study rationale and study protocol

scientific article published on July 2013

Extracellular Citrate and Cancer Metabolism-Response

scientific article published on 16 August 2018

Extracellular citrate affects critical elements of cancer cell metabolism and supports cancer development in vivo.

scientific article published on 6 March 2018

Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model

scientific article published on 17 June 2011

First-in-Human Case Study: Multipotent Adult Progenitor Cells for Immunomodulation After Liver Transplantation

scientific article published on 3 June 2015

GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term tumor development studies in immunocompetent mice

scientific article published in January 2003

HCC recurrence in HCV patients after liver transplantation: SiLVER Study reveals benefits of sirolimus in combination with CNIs

scientific article published on 21 April 2020

Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression ⬇️

scientific article published on 08 July 2013

Hepatocyte expression of soluble donor MHC class I antigen via gene transfer inhibits multiple aspects of the antidonor immune response in fully sensitized rat transplant recipients

scientific article published in October 2002

High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice

scientific article published in May 2010

Human Regulatory Macrophages ⬇️

scientific article published on 01 January 2011

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

scientific article published on 01 December 2019

Human regulatory macrophages as a cell-based medicinal product.

scientific article published on February 2012

Human transplant acceptance-inducing cells suppress mitogen-stimulated T cell proliferation.

scientific article published on 2 April 2009

Hurdles in therapy with regulatory T cells

scientific article published on September 2015

IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients

scientific article published on 28 August 2012

IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β.

scientific article published on 14 March 2014

IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis

scientific article

Immunological investigations empower transplant drug trials

scientific article published on 14 June 2018

Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model

scientific article published on 01 June 2006

Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of rapamycin

scientific article published on 05 December 2007

Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells

scientific article

Improved Outcome after ‘Bottom-Up’ Immunosuppression in Liver Transplant Recipients with Preoperative Renal Impairment ⬇️

scientific article published on November 22, 2010

In question: the scientific value of preclinical safety pharmacology and toxicology studies with cell-based therapies

scientific article

Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis

scientific article published on 01 May 2007

Influence of Immunosuppressive Drugs on the Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Gap Between Basic Science and Clinical Evidence ⬇️

scientific article published on June 15, 2011

Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo

scientific article published on March 2007

Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis

scientific article published on 27 April 2008

Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models

scientific article published on April 2017

Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis

Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice

scientific article published on 23 September 2011

Interleukin-33 prolongs allograft survival during chronic cardiac rejection

scientific article published on 28 July 2011

Lack of benefits of mammalian target of rapamycin inhibitor in patients transplanted for hepatocellular carcinoma: Is this the end of the story?

scientific article

Laser Ablation Inductively Coupled Plasma Mass Spectrometry: An Emerging Technology for Multiparametric Analysis of Tissue Antigens

scientific article

Laser ablation-inductively coupled plasma mass spectrometry: an emerging technology for detecting rare cells in tissue sections

scientific article

Late Deaths: What Can We Learn? ⬇️

scientific article published on June 15, 2011

MITAP-compliant characterization of human regulatory macrophages

scientific article

Macrophages driven to a novel state of activation have anti-inflammatory properties in mice

scientific article published on 01 January 2008

Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model

scientific article published on April 2007

Mesenchymal stem cells as immunomodulators after liver transplantation

scientific article published on October 2009

Mesenchymal stem cells can affect solid organ allograft survival

scientific article published on May 2009

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

scientific article published on 8 March 2017

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

scientific article published in January 2017

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

scientific article

Morbidity of hepatic resection for intermediate and advanced hepatocellular carcinoma

scientific article published on December 2015

Mouse β-Defensin 14 (Defb14) Promotes Tumor Growth by Inducing Angiogenesis in a CCR6-Dependent Manner ⬇️

scientific article published on April 13, 2012

Murine DX5NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4CD62L T Cells through Fas Ligand

scientific article published on 30 September 2018

Mycophenolate mofetil inhibits tumor growth and angiogenesis in vitro but has variable antitumor effects in vivo, possibly related to bioavailability

scientific article published on March 2007

Negative pressure wound therapy (NPWT) on closed incisions to prevent surgical site infection in high-risk patients in hepatopancreatobiliary surgery: study protocol for a randomized controlled trial-the NP-SSI trial

scientific article published on 09 November 2020

No Acceleration of UV-Induced Skin Carcinogenesis from Evenly Spread Dietary Intake of Cyclosporine in Contrast to Oral Bolus Dosages ⬇️

scientific article published on November 27, 2013

No contribution of multipotent mesenchymal stromal cells to liver regeneration in a rat model of prolonged hepatic injury

scientific article published on 16 November 2006

Now or never? The case for cell-based immunosuppression in kidney transplantation.

scientific article

Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors

scientific article published on February 1, 2012

Paclitaxel saves rat heart allografts from rejection by inhibition of the primed anti-donor humoral and cellular immune response: implications for transplant patients with cancer

scientific article published on 04 April 2003

Postoperative cellular stress in the kidney is associated with an early systemic γδ T-cell immune cell response.

scientific article published on 4 July 2018

Potential Use of Gluconate in Cancer Therapy

scientific article published on 19 June 2019

Predicting Early Viral Control under Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus Using Pretreatment Immunological Markers

scientific article published on 7 February 2018

Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells.

scientific article published on 10 July 2008

Procedures for ethical review for clinical trials within the EU.

scientific article published on 22 May 2009

RORγt(+) hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice

scientific article published on 15 May 2015

Randomized Sirolimus-based early calcineurin inhibitor reduction in liver transplantation: impact on renal function

scientific article published on 30 September 2019

Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis

scientific article

Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF.

scientific article published on 25 January 2005

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

scientific article published in February 2002

Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice

scientific article

Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer

scientific article published in March 2004

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

scientific article published on 01 May 2020

Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation.

scientific article published on August 2012

Reply to "How Far can we Expand Donor Age Criteria for Pancreas Transplantation?"

scientific article published on 04 September 2018

Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation--a phase I study (MISOT-I).

scientific article

Single cell tracking of gadolinium labeled CD4+ T cells by laser ablation inductively coupled plasma mass spectrometry

scientific article

Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial.

scientific article

Sirolimus promotes tolerance for donor and recipient antigens after MHC class II disparate bone marrow transplantation in rats

scientific article published on 01 January 2007

Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study

scientific article published on 25 October 2013

Study Protocol: A Pilot Study to Determine the Safety and Efficacy of Induction-Therapy, De Novo MPA and Delayed mTOR-Inhibition in Liver Transplant Recipients with Impaired Renal Function. PATRON-Study ⬇️

scientific article published on September 14, 2010

Subcutaneous Murine Xenograft Models: A Critical Tool for Studying Human Tumor Growth and Angiogenesis In Vivo

scientific article published on 01 January 2016

TIGIT iTregs elicited by human regulatory macrophages control T cell immunity

scientific article published in Nature Communications

Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer.

scientific article

Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.

scientific article

Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces or

scientific article published on November 2007

Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice

scientific article

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scientific article published on 01 August 2016

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The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation ⬇️

scientific article published on September 22, 2010

Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group

article

Toward cell-based therapy of type I diabetes

scientific article published on 07 January 2008

Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation.

scientific article published on 10 July 2008

Transplantation: can sirolimus prevent skin cancer in transplant recipients?

scientific article published on November 1, 2010

Treatment-emergent adverse events after infusion of adherent stem cells: the MiSOT-I score for solid organ transplantation ⬇️

scientific article published on November 15, 2012

Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha

scientific article published on 11 August 2009

Use of an adenoviral vector to express soluble donor-major histocompatibility complex molecules capable of suppressing the immune response in rat transplant recipients

scientific article published on 01 October 2002

Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

scientific article published on 22 February 2019

mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors

scientific article published on 03 September 2020

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