List of works - P Edward Purdue

Adverse local tissue reaction (ALTR) associated with corrosion products in metal-on-metal and dual modular neck total hip replacements is associated with upregulation of interferon gamma-mediated chemokine signaling.

scientific article published on 18 May 2015

Alternative macrophage activation in periprosthetic osteolysis

scientific article published on April 2008

Bone remodelling in inflammatory arthritis

scientific article published on 19 December 2012

Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate

scientific article published on 23 December 2014

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

scientific article

Development of polymeric nanocarrier system for early detection and targeted therapeutic treatment of peri-implant osteolysis

scientific article published on 27 December 2012

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates

scientific article

Early diagnosis of orthopedic implant failure using macromolecular imaging agents

scientific article published on 4 March 2014

Elevation of serum tumor necrosis factor α in patients with periprosthetic osteolysis: a case-control study

scientific article published on February 2014

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

scientific article published on 4 October 2009

Functional analysis of the 5'-flanking region of the human alanine:glyoxylate aminotransferase gene AGXT.

scientific article

HPMA-Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer.

scientific article

Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases

scientific article

Implant based differences in adverse local tissue reaction in failed total hip arthroplasties: a morphological and immunohistochemical study

scientific article

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

scientific article published on 08 December 2013

Nano-analyses of wear particles from metal-on-metal and non-metal-on-metal dual modular neck hip arthroplasty ⬇️

scientific article published on 22 November 2016

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling

scientific article

Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis.

scientific article published on 9 October 2015

Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis

scientific article published on 22 April 2015

Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae

scientific article

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

scientific article published on 25 March 2017

Simvastatin prodrug micelles target fracture and improve healing

scientific article

Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy

scientific article

The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

scientific article published on 10 May 2016

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

scientific article

The cellular and molecular biology of periprosthetic osteolysis

scientific article published on January 2007

The central role of wear debris in periprosthetic osteolysis

scientific article published on September 2006

The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate

scientific article

Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis

scientific article published in April 2006

List of works by P Edward Purdue

Adverse local tissue reaction (ALTR) associated with corrosion products in metal-on-metal and dual modular neck total hip replacements is associated with upregulation of interferon gamma-mediated chemokine signaling.

Alternative macrophage activation in periprosthetic osteolysis

Bone remodelling in inflammatory arthritis

Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

Development of polymeric nanocarrier system for early detection and targeted therapeutic treatment of peri-implant osteolysis

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates

Early diagnosis of orthopedic implant failure using macromolecular imaging agents

Elevation of serum tumor necrosis factor α in patients with periprosthetic osteolysis: a case-control study

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

Functional analysis of the 5'-flanking region of the human alanine:glyoxylate aminotransferase gene AGXT.

HPMA-Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer.

Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases

Implant based differences in adverse local tissue reaction in failed total hip arthroplasties: a morphological and immunohistochemical study

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

Nano-analyses of wear particles from metal-on-metal and non-metal-on-metal dual modular neck hip arthroplasty ⬇️

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling

Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis.

Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis

Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Simvastatin prodrug micelles target fracture and improve healing

Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy

The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

The cellular and molecular biology of periprosthetic osteolysis

The central role of wear debris in periprosthetic osteolysis

The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate

Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis