List of works - Takayuki Hattori

ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells

scientific article

Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase

scientific article published on 13 August 2009

C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer

scientific article

C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform

scientific article (publication date: 24 April 2003)

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

scientific article

Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats

scientific article published on 18 June 2009

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

scientific article published on September 2006

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

scientific article published on 15 March 2018

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

scientific article published on 15 September 2016

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

scientific article published on 8 June 2017

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

scientific article published on 9 September 2016

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

scientific article published on 11 October 2013

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

scientific article

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)

scientific article published on 26 October 2018

Distinct and site-specific phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells

scientific article published on 21 January 2014

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

scholarly article

Effects of MdmX on Mdm2-mediated downregulation of pRB

scientific article

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

scientific article

Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor.

scientific article published on March 2006

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

scientific article

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

scientific article

Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015.

scientific article published on 13 May 2015

Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner

scientific article published on 6 December 2005

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

scientific article published in January 2016

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

scientific article published in Scientific Reports

Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit

scientific journal article

Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

scientific article

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

scientific article

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy

scientific article

Reduction of Anterior Chamber Contamination Rate After Cataract Surgery by Intraoperative Surface Irrigation With 0.25% Povidone–Iodine ⬇️

scientific article published on October 20, 2010

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

scientific article

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

scientific article published on 2 August 2017

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

scientific article

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

scientific article

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

scientific article published on 14 September 2017

Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta

scientific article (publication date: 9 May 2005)

Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.

scientific article

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

scientific article

List of works by Takayuki Hattori

ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells

Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase

C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer

C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)

Distinct and site-specific phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

Effects of MdmX on Mdm2-mediated downregulation of pRB

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor.

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015.

Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit

Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy

Reduction of Anterior Chamber Contamination Rate After Cataract Surgery by Intraoperative Surface Irrigation With 0.25% Povidone–Iodine ⬇️

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta

Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis