List of works - Haruhiko Akiyama

4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy.

scientific article

A mouse reporter line to conditionally mark nuclei and cell membranes for in vivo live-imaging

scientific article

ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice

scientific article published on 28 March 2018

Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

scientific article

Arid1a is essential for intestinal stem cells through Sox9 regulation

scientific article published on 11 January 2019

Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.

scientific article

Contributions of biarticular myogenic components to the limitation of the range of motion after immobilization of rat knee joint

scientific article

Cthrc1 is a positive regulator of osteoblastic bone formation

scientific journal article

Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

scientific article

Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.

scientific article

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa

scientific journal article

Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain ⬇️

scientific article published on October 29, 2003

Generation of transgenic mice for conditional overexpression of Sox9 ⬇️

scientific article published on July 30, 2010

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

scientific article

Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts

scientific article

Lung epithelial branching program antagonizes alveolar differentiation

scientific journal article

Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

scientific article

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

scientific article

Morphometric analysis of testis cord formation in Sox9-EGFP mice

scientific article

Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia

scientific article (publication date: July 2002)

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

scientific article

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

scientific article

Pathological alpha-synuclein propagates through neural networks

scientific article

Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

scientific article

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

scientific article

Positive florbetapir PET amyloid imaging in a subject with frequent cortical neuritic plaques and frontotemporal lobar degeneration with TDP43-positive inclusions

scientific article

Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix

scientific article

Progressive nonfluent aphasia: A rare clinical subtype of FTLD‐TDP in Japan ⬇️

scientific article published on October 6, 2011

Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells

scientific article

SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells

scientific journal article

Sequential and Coordinated Actions of c-Myc and N-Myc Control Appendicular Skeletal Development ⬇️

scientific article published on April 11, 2011

Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse.

scientific article

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest

scientific article

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways ⬇️

scientific article published on March 2, 2011

Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists: additional autopsy case with a clinical course of 19 years

scientific article

Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy: a report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions

scientific article

Tau accumulation in the nucleus accumbens in tangle-predominant dementia

scientific article

Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation

scientific journal article

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis

article by Motoyuki Tsuda et al published 1 August 2018 in Journal of Clinical Investigation

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

scientific article

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

scientific journal article

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.

scientific article

Transient development of ovotestes in XX Sox9 transgenic mice ⬇️

scientific article published on October 19, 2010

Two nested developmental waves demarcate a compartment boundary in the mouse lung

scientific article

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

scientific article (publication date: April 2008)

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

scientific journal article

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation

scientific journal article

List of works by Haruhiko Akiyama

4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy.

A mouse reporter line to conditionally mark nuclei and cell membranes for in vivo live-imaging

ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice

Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

Arid1a is essential for intestinal stem cells through Sox9 regulation

Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.

Contributions of biarticular myogenic components to the limitation of the range of motion after immobilization of rat knee joint

Cthrc1 is a positive regulator of osteoblastic bone formation

Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa

Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain ⬇️

Generation of transgenic mice for conditional overexpression of Sox9 ⬇️

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts

Lung epithelial branching program antagonizes alveolar differentiation

Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

Morphometric analysis of testis cord formation in Sox9-EGFP mice

Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

Pathological alpha-synuclein propagates through neural networks

Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

Positive florbetapir PET amyloid imaging in a subject with frequent cortical neuritic plaques and frontotemporal lobar degeneration with TDP43-positive inclusions

Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix

Progressive nonfluent aphasia: A rare clinical subtype of FTLD‐TDP in Japan ⬇️

Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells

SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells

Sequential and Coordinated Actions of c-Myc and N-Myc Control Appendicular Skeletal Development ⬇️

Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse.

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways ⬇️

Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists: additional autopsy case with a clinical course of 19 years

Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy: a report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions

Tau accumulation in the nucleus accumbens in tangle-predominant dementia

Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.

Transient development of ovotestes in XX Sox9 transgenic mice ⬇️

Two nested developmental waves demarcate a compartment boundary in the mouse lung

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation