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List of works by Benoit de Crombrugghe

A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6.

scientific article published on 23 November 2016

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

scientific article

A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.

scientific article

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene ⬇️

scientific article published on October 1, 1998

A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene

scientific article (publication date: 27 December 2002)

Abnormal craniofacial morphology and cartilage structure in transgenic mice harboring a Gly --> Cys mutation in the cartilage-specific type II collagen gene

scientific article published on 01 July 1993

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements

scientific article

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice

scientific article

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

scientific article

Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes ⬇️

scientific article published on September 15, 1993

Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice

scientific article published on 01 August 1994

Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification ⬇️

scientific article published on January 21, 2012

Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice

scientific article

Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain

scientific article published on July 1992

Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor

scientific article

Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes

scientific journal article

Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

scientific article published on June 1995

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

scientific article

Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation

scientific article

Coordinate patterns of expression of type I and III collagens during mouse development

scientific article published in December 1995

Correction: SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters.

scientific article published on 12 November 2015

Cthrc1 is a positive regulator of osteoblastic bone formation

scientific journal article

Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure

scientific article

Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice

scientific article published in October 1995

E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein

scientific article published on 23 October 2013

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa

scientific journal article

Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors

scientific article

Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family

scientific article (publication date: 13 April 2001)

Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage

scientific article published on December 2009

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

scientific journal article

Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix

scientific article

Identification of SOX9 interaction sites in the genome of chondrocytes

scientific article

Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9.

scientific article

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

scientific article

Joint formation requires muscle formation and contraction

scientific article published in May 2009

Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis

scientific article published on May 2002

Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation

scientific article published on 3 March 2015

Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation

scientific article published on 6 March 2015

Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing

scientific article

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

scientific article

NFAT and Osterix cooperatively regulate bone formation

scientific article

Normal long bone growth and development in type X collagen-null mice

scientific article published on 01 October 1994

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

scientific article

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

scientific article published on 01 July 2000

Osterix is required for cranial neural crest-derived craniofacial bone formation

scientific article

Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma

scientific article

Persistent low level of osterix accelerates interleukin-6 production and impairs regeneration after tissue injury

scientific article

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer

scientific article

Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix

scientific article

Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance

scientific article

Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

scientific article

Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor

scientific journal article

Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3

scientific journal article

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

scientific journal article

Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase

scientific article

SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc.

scientific article published on 20 July 2016

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium

scientific journal article

SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters

scientific article

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

scientific article

Sox9 is required for cartilage formation

scientific journal article

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest

scientific article

Sp7 and Runx2 molecular complex synergistically regulate expression of target genes

scientific article

Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter

scientific article

Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs.

scientific article published in February 1992

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs

scientific article published in June 1991

Specificity protein 7 is not essential for tooth morphogenesis.

scientific article

Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression

scientific article

TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation

scientific article

Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation

scientific journal article

The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor

scientific article

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones

scientific journal article

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

scientific article

The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene

scientific article published on February 1994

The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern

scientific article published on January 1993

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

scientific article

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

scientific journal article

Toward understanding S0X9 function in chondrocyte differentiation ⬇️

scientific article published on March 1, 1998

Transcriptional control mechanisms for the expression of type I collagen genes ⬇️

scientific article published on November 1, 1991

Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts

scientific article published on 22 November 2011

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.

scientific article published on 4 April 2008

Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth

scientific article

Transgenic mice with deficiencies in cartilage collagens: possible models for gene therapy.

scientific article published on February 1995

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

scientific journal article

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

scientific article

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