List of works - Luigi Zecca

194. Neuromelanin-Sensitive MRI as an Early Indicator of Dopamine Dysfunction in Individuals at Risk for Psychosis.

scientific article

Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease

scientific article published on 21 January 2003

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

scientific article published on 10 March 2021

An XAS study of the sulfur environment in human neuromelanin and its synthetic analogs.

scientific article published on 27 May 2009

Biosynthetic pathway to neuromelanin and its aging process

scientific article published on 01 October 2012

COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside

scientific article published on 20 August 2020

Challenges associated with metal chelation therapy in Alzheimer's disease

scientific article

Contrast mechanisms associated with neuromelanin-MRI.

scientific article published on 26 December 2016

Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson

scientific article published on 15 June 2023

Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases

scientific article published on 21 March 2019

Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry

scientific article

Engineered nanoparticles. How brain friendly is this new guest?

scientific article

Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI

scientific article published on 28 August 2020

High-performance liquid chromatographic analysis of flavonol glycosides of Solidago virgaurea

Highly Effective Protocol for Differentiation of Induced Pluripotent Stem Cells (iPS) into Melanin-Producing Cells

scientific article published in 2021

Human immunodeficiency virus type 1 alters brain-derived neurotrophic factor processing in neurons

scientific article

Human neuromelanin an endogenous microglial activator for dopaminergic neuron death ⬇️

scientific article published on January 1, 2013

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

scientific article

Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain

scientific article published on 19 April 2007

In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage

scientific article published in October 2005

Interaction of Human Substantia Nigra Neuromelanin with Lipids and Peptides

Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models

Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

scientific article

Intraneuronal dopamine-quinone synthesis: A review

scientific article

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

scientific article published on 29 April 2019

Iron, brain ageing and neurodegenerative disorders

scientific article (publication date: November 2004)

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

scientific article

Iron-binding characteristics of neuromelanin of the human substantia nigra.

scientific article published in August 2003

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

scientific article published on 01 September 2019

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

scientific article

Melanins and melanogenesis: from pigment cells to human health and technological applications

scientific article

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

scientific article (publication date: 2007)

Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease

scientific article published on 22 August 2016

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

scientific article

Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease

scientific article

Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease

scientific article published on 4 July 2008

Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease

scientific article published on 10 April 2018

Neuromelanin inhibits CXCL10 expression in human astroglial cells ⬇️

scientific article published on September 17, 2010

Neuromelanin of the human substantia nigra: an update

scientific article published on 24 October 2013

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics ⬇️

scientific article published on November 1, 2003

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease.

scientific article

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

scientific article published on 22 February 2019

Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role

Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids

scientific article published on 20 January 2009

Neuromelanins isolated from different regions of the human brain exhibit a common surface photoionization threshold

scientific article published on 19 November 2008

Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure

scientific article

Neuronal MHC-I display in T-cell mediated neurodegeneration

Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases

scientific article published on 26 July 2019

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

scientific article published on April 2008

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

scholarly article

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

scientific article

Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease

Onset and mortality of Parkinson's disease in relation to type II diabetes

Overexpression of Vesicular Monoamine Transporter-2 may Block Neurotoxic Metabolites from Cytosolic Dopamine: a Potential Neuroprotective Therapy for Parkinson's Disease

scientific article published on 06 May 2019

Protective and toxic roles of dopamine in Parkinson's disease

scientific article published on 18 March 2014

Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin.

scientific article published on 16 June 2014

Structure and Function of Neuromelanin

Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis ⬇️

scientific article published on October 31, 2012

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease.

scientific article published on 28 November 2016

Ten years of Nature Reviews Neuroscience: insights from the highly cited

scientific article

The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

scientific article published on 01 January 2002

The effect on rat thymocytes of the simultaneous in vivo exposure to 50-Hz electric and magnetic field and to continuous light.

scientific article published on 20 October 2004

The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects

scientific article published on 18 August 2020

The neuromelanin of human substantia nigra: physiological and pathogenic aspects

scientific article

The protective and toxic role of neuromelanins in brain aging and Parkinson’s disease

scientific article published on 12 June 2015

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

scholarly article

The role of iron in brain ageing and neurodegenerative disorders.

scientific article

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease

The structure of neuromelanin as studied by chemical degradative methods

scientific article published in August 2003

The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface

scientific article

Tracemetals, neuromelanin and neurodegeneration: An interesting area for research

scientific article

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

scientific article published on 21 December 2018

List of works by Luigi Zecca

194. Neuromelanin-Sensitive MRI as an Early Indicator of Dopamine Dysfunction in Individuals at Risk for Psychosis.

Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

An XAS study of the sulfur environment in human neuromelanin and its synthetic analogs.

Biosynthetic pathway to neuromelanin and its aging process

COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside

Challenges associated with metal chelation therapy in Alzheimer's disease

Contrast mechanisms associated with neuromelanin-MRI.

Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson

Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases

Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano-secondary ion mass spectrometry

Engineered nanoparticles. How brain friendly is this new guest?

Evidence for Dopamine Abnormalities in the Substantia Nigra in Cocaine Addiction Revealed by Neuromelanin-Sensitive MRI

High-performance liquid chromatographic analysis of flavonol glycosides of Solidago virgaurea

Highly Effective Protocol for Differentiation of Induced Pluripotent Stem Cells (iPS) into Melanin-Producing Cells

Human immunodeficiency virus type 1 alters brain-derived neurotrophic factor processing in neurons

Human neuromelanin an endogenous microglial activator for dopaminergic neuron death ⬇️

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain

In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage

Interaction of Human Substantia Nigra Neuromelanin with Lipids and Peptides

Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models

Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

Intraneuronal dopamine-quinone synthesis: A review

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

Iron, brain ageing and neurodegenerative disorders

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

Iron-binding characteristics of neuromelanin of the human substantia nigra.

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Melanins and melanogenesis: from pigment cells to human health and technological applications

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease

Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease

Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease

Neuromelanin inhibits CXCL10 expression in human astroglial cells ⬇️

Neuromelanin of the human substantia nigra: an update

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics ⬇️

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease.

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role

Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids

Neuromelanins isolated from different regions of the human brain exhibit a common surface photoionization threshold

Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure

Neuronal MHC-I display in T-cell mediated neurodegeneration

Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease

Onset and mortality of Parkinson's disease in relation to type II diabetes

Overexpression of Vesicular Monoamine Transporter-2 may Block Neurotoxic Metabolites from Cytosolic Dopamine: a Potential Neuroprotective Therapy for Parkinson's Disease

Protective and toxic roles of dopamine in Parkinson's disease

Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin.

Structure and Function of Neuromelanin

Synthesis and structural characterization of soluble neuromelanin analogs provides important clues to its biosynthesis ⬇️

Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease.

Ten years of Nature Reviews Neuroscience: insights from the highly cited

The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

The effect on rat thymocytes of the simultaneous in vivo exposure to 50-Hz electric and magnetic field and to continuous light.

The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects

The neuromelanin of human substantia nigra: physiological and pathogenic aspects

The protective and toxic role of neuromelanins in brain aging and Parkinson’s disease

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

The role of iron in brain ageing and neurodegenerative disorders.

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease

The structure of neuromelanin as studied by chemical degradative methods

The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface

Tracemetals, neuromelanin and neurodegeneration: An interesting area for research

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

Water‐Soluble Melanin–Protein–Fe/Cu Conjugates Derived from Norepinephrine as Reliable Models for Neuromelanin of Human Brain Locus Coeruleus

Water‐Soluble Melanin–Protein–Fe/Cu Conjugates Derived from Norepinephrine as Reliable Models for Neuromelanin of Human Brain Locus Coeruleus