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List of works by Kazuyuki Takata

3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats

scientific article

A novel dipeptide type inhibitor of the Wnt/β-catenin pathway suppresses proliferation of acute myelogenous leukemia cells

scientific article published on 17 December 2020

Accelerative effects of carbazole-type alkaloids from Murraya koenigii on neurite outgrowth and their derivative's in vivo study for spatial memory

scientific article published on 20 January 2020

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mous

scientific article published on 22 November 2017

Bone-Marrow-Derived Microglia-Like Cells Ameliorate Brain Amyloid Pathology and Cognitive Impairment in a Mouse Model of Alzheimer's Disease

scientific article published on 01 January 2018

CG13250, a novel bromodomain inhibitor, suppresses proliferation of multiple myeloma cells in an orthotopic mouse model

scientific article published on 20 January 2017

DJ-1 Contributes to Self-renewal of Stem Cells in the U87-MG Glioblastoma Cell Line

scientific article published on 01 November 2019

DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats

scientific article published on 19 September 2007

Daphnetin inhibits invasion and migration of LM8 murine osteosarcoma cells by decreasing RhoA and Cdc42 expression

scientific article published on February 2016

Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration

scientific article published on 23 October 2007

Detoxification of 6-hydroxydopamine-induced Parkinsonian neurodegeneration by G-CYPMPO, a novel radical trapper

scientific article published on 17 February 2011

Detoxification of 6-hydroxydopamine-induced dopaminergic neurodegeneration by 5,5-dimethyl-1-pyrroline N-oxide, a radical trapper, in hemiparkinsonian rats

scientific article published in January 2012

Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus

scientific article published on 16 October 2006

Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain

scientific journal article

Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model

scientific article published on 18 April 2012

Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components

scientific article

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.

scientific article published on 21 September 2016

Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease

scientific article

Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

scientific article

Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules

Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo

scientific article

High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity

scientific article published in December 2004

Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells

scientific article

Hyperbilirubinemia protects against focal ischemia in rats

scientific article published in February 2003

Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells

scientific article published on 7 September 2006

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

scientific article published on 01 February 2020

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

scientific article published on July 2017

Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells

scientific article published on 22 February 2016

Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.

scientific article published in August 2008

Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model

scientific article published in June 2003

Intracerebroventricular injection of microglia protects against focal brain ischemia

scientific article published on 01 February 2004

Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease

scientific article published on 04 June 2009

Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia

scientific article

Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease

scientific article

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins

scientific article published in April 2002

Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats

scientific article

Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: tangle formation, amyloid-β, and microglia in Alzheimer's disease

scientific article

Molecular targeting and translational research for new therapeutic strategies on Alzheimer's disease

scientific article

Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells

scientific article published on 10 November 2006

Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ

scientific article published on 01 July 2020

Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

scientific article

Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice.

scientific article

Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke

scientific article published on 01 August 2020

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

scientific article

Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.

scientific article

Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury

scientific article (publication date: 2009)

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model

scientific article published on 24 July 2006

Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice

scientific article published in January 2011

Pathological changes induced by amyloid-β in Alzheimer's disease

scientific article published in January 2011

Peripheral Blood-Derived Microglia-Like Cells Decrease Amyloid-β Burden and Ameliorate Cognitive Impairment in a Mouse Model of Alzheimer's Disease

scientific article published on 01 January 2020

Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome

scientific article published on 04 July 2019

Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica

scientific article

Poised for action: USP18 restrains microglial activation in the white matter

scientific article published on 13 May 2015

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation

scientific article published on April 1, 2003

Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats

scientific article published in June 2008

Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease

scientific article

Possible involvement of both endoplasmic reticulum-and mitochondria-dependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells

scientific article published in July 2003

Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.

scientific article

Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.

scientific article

Protection against oxidative stress-induced neurodegeneration by a modulator for DJ-1, the wild-type of familial Parkinson's disease-linked PARK7.

scientific article published on 11 March 2009

Protective effect of planarian DJ-1 against 6-hydroxydopamine-induced neurotoxicity

scientific article

Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates

scientific article published in July 2007

Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia

scientific article

Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis

scientific article published in February 2003

Role of transient receptor potential vanilloid subtype 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice

scientific article published on 10 December 2019

Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats

scientific article published on 31 August 2005

Stress proteins and regulation of microglial amyloid-beta phagocytosis

scientific article

Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model

scientific article

Targeting innate immunity for neurodegenerative disorders of the central nervous system

scientific article

Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models

scientific article published in January 2015

The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra

scientific article published on November 2010

The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues

scientific article published on 17 August 2009

Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice.

scientific article

Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats

scientific article published on October 2005

[Next stages of drug discovery and evolution for intractable diseases created by young pharmacologists]

scientific article published on 01 January 2014

α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior

scientific article

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