List of works - Hyoung-gon Lee

4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal

scientific article published on August 2005

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

scientific article

Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease

scientific article published on 11 February 2004

Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease

scientific article published on 27 October 2006

Accumulation of intraneuronal amyloid-β is common in normal brain.

scientific article

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

scientific article

Alzheimer Disease: Oxidative Stress and Compensatory Responses

article

Alzheimer disease pathology as a host response

scientific article published on June 2008

Alzheimer disease, the two-hit hypothesis: an update

scientific article published on 27 October 2006

Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome

scientific article published on 15 February 2012

Amyloid beta: the alternate hypothesis

scientific article

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

scientific article

Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!

scientific article published on September 2006

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain ⬇️

scientific article published on March 10, 2011

Amyloids, Aggregates and Neuronal Inclusions: Good or Bad News for Neurons?

article

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

scientific article

Antioxidant approaches for the treatment of Alzheimer's disease

scientific article published on July 2010

Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.

scientific article

Autophagy in Alzheimer's disease

scientific article published on July 2010

BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease

scientific article published on 12 May 2007

Biomarkers in Alzheimer's disease: past, present and future

scientific article

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease

scientific article

CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease

scientific article

Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis

scientific article

Cell cycle deregulation in the neurons of Alzheimer's disease

scientific article published on January 2011

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

scientific article

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

scientific article published on 09 December 2008

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

scientific article published on 18 November 2011

Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease

scientific article published in June 2004

Chapter 19. Targeting Oxidative Mechanisms in Alzheimer Disease

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

scientific article

Chronological primacy of oxidative stress in Alzheimer disease

scientific article published in May 2005

Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders

scientific article

Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model

scientific article published on 20 April 2015

Current approaches in the treatment of Alzheimer's disease

scientific article published on 17 March 2008

Differential regulation of glutamate receptors in Alzheimer's disease

scientific article

Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study

article

Disturbance in AMP-activated protein kinase (AMPK) signaling pathway in Alzheimer's disease

Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship.

scientific article

Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice

scientific article

Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits

scientific article

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

scientific article published on 21 August 2013

Early induction of c-Myc is associated with neuronal cell death ⬇️

scientific article published on October 8, 2011

Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity

scientific article

Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?

scientific article published in December 2006

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

scientific article published on 23 July 2009

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

scientific article published on 26 February 2003

Emerging evidence for the neuroprotective role of alpha-synuclein

scientific article

Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain.

scientific article published on 20 October 2008

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

scientific article published on April 2009

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

scientific article published on 23 April 2008

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

scientific article published on December 2008

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

scientific journal article

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

scientific article published on 8 December 2011

Increased p27, an essential component of cell cycle control, in Alzheimer's disease

scientific article published in April 2003

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

scientific article

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

scientific article

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

scientific article published on 23 December 2009

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease

scientific article

Iron: A Pathological Mediator of Alzheimer Disease? ⬇️

scientific article published on January 31, 2009

Mark A. Smith

Mark A. Smith, 1965-2010: consummate student of pathogenesis

scientific article published on 10 October 2011

Mark A. Smith: neurocytochemistry innovator

scientific article published on 23 January 2012

Mark A. Smith: the scientist, the man.

scientific article published in October 2011

Mark Smith: Pioneer of Alzheimer Disease Research

Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease

scientific article

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

scientific article

Mitochondria: a therapeutic target in neurodegeneration

scientific article published on 21 October 2009

Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease

scientific article published in February 2005

Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation

scientific article published in January 2013

Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats

scientific article

Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress

scientific article

Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches

scientific article published on 26 March 2009

Neurodegenerative processes in Alzheimer’s disease: an overview of pathogenesis with strategic biomarker potential

Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease

article

Neurogenesis in Alzheimer’s Disease

Neurogenesis in Human Hippocampus: Implications for Alzheimer Disease Pathogenesis

Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

scientific article

Neuronal leptin resistance in Alzheimer's disease

scholarly article by David Bonda et al published July 2013 in Alzheimer's and Dementia

Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?

scientific article published on May 2007

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream

scientific article published on 3 May 2006

Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

scientific article

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

scientific article

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

Neuroprotective properties of Bcl-w in Alzheimer disease

scientific article

Novel therapeutics for Alzheimer's disease: an update

scientific article

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

scientific article published on 23 January 2012

Oxidative Adaptation in Aging and Alzheimer’s Disease

Oxidative Stress and Alzheimer Disease: Mechanisms and Therapeutic Opportunities

Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy

article

Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

scientific article

Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?

scientific article

Oxidative damage to RNA in aging and neurodegenerative disorders

scientific article published on 06 June 2012

Oxidative imbalance in Alzheimer's disease

scientific article

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

scientific article

Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways

scientific article published on October 2003

Oxidative stress signalling in Alzheimer's disease

scientific article published on March 2004

P1-266 The critical role of the ERK pathway in the pathogenesis of Alzheimer's disease

scholarly article by Xiongwei Zhu et al published July 2004 in Neurobiology of Aging

P1-351: A novel approach to diagnosis: Antigen-antibody disassociation in Alzheimer's disease

scholarly article by Mark A. Smith et al published July 2008 in Alzheimer's and Dementia

P3-306 Differential expression of metabotrophic glutamate receptors (MGlurs) in Alzheimer disease

P3-317: Failure in the control of cell cycle causes neurodegeneration

P38 activation mediates amyloid-beta cytotoxicity

scientific article published on June 2005

Pathological implications of cell cycle re-entry in Alzheimer disease

scientific article

Pathological phenotype in familial neurodegenerative disease: implications for families and therapeutic constructs

Pathology's new role: defining disease process and protective responses.

scientific article published in January 2008

Perspectives on the amyloid-beta cascade hypothesis

scientific article published on April 2004

Phosphorylated tau: toxic, protective, or none of the above

scientific article published on August 2008

Posttranslational modifications of α-tubulin in alzheimer disease

scientific article

Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".

scientific article published on 19 January 2006

Presenilin mutations impair mitochondrial dynamics in neurons

Protein Misfolding in Alzheimer's Disease

scholarly article published 3 December 2007

R-_-Lipoic Acid as a Potent Agent of Mitochondrial Protectionin Alzheimer’s Disease

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

scientific article

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

scientific article published on January 2008

Role of metal dyshomeostasis in Alzheimer's disease

scientific article

Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy

scientific article published on March 2006

Signal transduction cascades associated with oxidative stress in Alzheimer's disease

scientific article published on May 2007

Staying connected: synapses in Alzheimer disease

scientific article

Tau modifiers as therapeutic targets for Alzheimer's disease

scientific article

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

scientific article (publication date: April 2005)

The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

scientific article

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

scientific article

The concept of redox balance in Alzheimer's disease: Mark Anthony Smith 1965–2010

scholarly article by Xiongwei Zhu et al published March 2011 in Redox Report

The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons

scientific article published on March 2012

The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

scientific article

The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells

scientific article published on 13 January 2009

The fallacy of amyloid and cognition in Alzheimer's disease

scientific article published in January 2006

The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention

scientific article published on January 2011

The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

scientific article published on 22 January 2009

The origin of oxidative stress in neurodegenerative disease: Mark Anthony Smith 1965–2010

The role of E2F1 in the development of hypertrophic cardiomyopathy ⬇️

scientific article published on June 7, 2011

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

scientific article

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

scientific article

Therapeutic opportunities in Alzheimer disease: one for all or all for one?

scientific article

Thinking Outside the Box in Alzheimer Disease Treatment

Treatment advances in Alzheimer's disease based on the oxidative stress model

scientific article

Untangling the Vascular Web from Alzheimer Disease and Oxidative Stress ⬇️

scientific article published on January 1, 2012

Widespread distribution of reticulon-3 in various neurodegenerative diseases

scientific article

Will Preventing Protein Aggregates Live Up to Its Promise as Prophylaxis Against Neurodegenerative Diseases?

article

Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?

scientific article published on October 2003

List of works by Hyoung-gon Lee

4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease

Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease

Accumulation of intraneuronal amyloid-β is common in normal brain.

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

Alzheimer Disease: Oxidative Stress and Compensatory Responses

Alzheimer disease pathology as a host response

Alzheimer disease, the two-hit hypothesis: an update

Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome

Amyloid beta: the alternate hypothesis

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain ⬇️

Amyloids, Aggregates and Neuronal Inclusions: Good or Bad News for Neurons?

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

Antioxidant approaches for the treatment of Alzheimer's disease

Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.

Autophagy in Alzheimer's disease

BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease

Biomarkers in Alzheimer's disease: past, present and future

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease

CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease

Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis

Cell cycle deregulation in the neurons of Alzheimer's disease

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease

Chapter 19. Targeting Oxidative Mechanisms in Alzheimer Disease

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

Chronological primacy of oxidative stress in Alzheimer disease

Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders

Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model

Current approaches in the treatment of Alzheimer's disease

Differential regulation of glutamate receptors in Alzheimer's disease

Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study

Disturbance in AMP-activated protein kinase (AMPK) signaling pathway in Alzheimer's disease

Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship.

Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice

Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

Early induction of c-Myc is associated with neuronal cell death ⬇️

Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity

Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

Emerging evidence for the neuroprotective role of alpha-synuclein

Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain.

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

Increased p27, an essential component of cell cycle control, in Alzheimer's disease

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease

Iron: A Pathological Mediator of Alzheimer Disease? ⬇️

Mark A. Smith

Mark A. Smith, 1965-2010: consummate student of pathogenesis

Mark A. Smith: neurocytochemistry innovator

Mark A. Smith: the scientist, the man.

Mark Smith: Pioneer of Alzheimer Disease Research

Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

Mitochondria: a therapeutic target in neurodegeneration

Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease

Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation

Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats

Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress

Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches

Neurodegenerative processes in Alzheimer’s disease: an overview of pathogenesis with strategic biomarker potential

Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease

Neurogenesis in Alzheimer’s Disease

Neurogenesis in Human Hippocampus: Implications for Alzheimer Disease Pathogenesis

Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

Neuronal leptin resistance in Alzheimer's disease