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List of works by Cassandra Koole

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

scientific article

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

scientific article

Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.

scientific article published on 28 January 2015

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

scientific article

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery

scientific article published on 17 July 2013

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

scientific article published on 21 February 2018

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

scientific article

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

scientific article published on February 2013

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.

scientific article published on 6 December 2011

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

scientific article published on 6 December 2011

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

scientific article

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.

scientific article published in May 2018

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