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List of works by Kiichi Nakahira

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS

scientific article published on 06 December 2018

A protective role of interleukin 11 on hepatic injury in acute endotoxemia

scientific article published in February 2004

Apolipoprotein E and Periostin Are Potential Biomarkers of Nasal Mucosal Inflammation. A Parallel Approach of In Vitro and In Vivo Secretomes

scientific article published on 01 January 2020

Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome

scientific article published on 01 August 2019

Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

scientific article published on 26 April 2021

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

scientific article published on 13 February 2020

Autophagy in Pulmonary Diseases

scientific article

Autophagy in pulmonary diseases

scientific article published on 24 October 2011

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

scientific article (publication date: March 2011)

Autophagy: Friend or Foe in Lung Disease?

scientific article published on March 2016

Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease

scientific article published on 26 September 2013

Autophagy: a potential therapeutic target in lung diseases ⬇️

scientific article published on May 24, 2013

BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension

scientific article

Carbon Monoxide Confers Protection in Sepsis by Enhancing Beclin 1-Dependent Autophagy and Phagocytosis ⬇️

scientific article published on 05 October 2013

Carbon Monoxide Protects against Hyperoxia-induced Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Formation

scientific article published in Journal of Biological Chemistry

Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation

scientific article published on 25 March 2011

Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

scientific article

Carbon monoxide in the treatment of sepsis

scientific article

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages

scientific article published on 13 March 2015

Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages

scientific article

Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

scientific article published on 25 November 2020

Cell-free DNA in human ex vivo lung perfusate as a potential biomarker to predict the risk of primary graft dysfunction in lung transplantation

scientific article published on 11 August 2020

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

scientific article

Circulating Mitochondrial DNA as Predictor of Mortality in Critically Ill Patients: A Systematic Review of Clinical Studies

scientific article published on 02 August 2019

Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation

scientific article (publication date: December 2013)

Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit.

scientific article published on 26 March 2017

Dampening insulin signaling by an NLRP3 'meta-flammasome' ⬇️

scientific article published on 01 May 2011

Diurnal Rhythms Spatially and Temporally Organize Autophagy

article published in 2019

Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease

scientific article

Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts

scientific article published on 16 July 2008

Fatty acid synthesis and NLRP3-inflammasome

scientific article published on 3 July 2015

Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner

scientific article published on August 2009

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses

scientific article published on 01 January 2006

Heteroplasmy concordance between mitochondrial DNA and RNA

scientific article published on 10 September 2019

Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity

scientific article published on 01 October 2006

Inflammasome-regulated cytokines are critical mediators of acute lung injury

scientific article

Inflammasomes: Key Mediators of Lung Immunity

scientific article published on February 2017

Mechanisms of cell death in oxidative stress

scientific article published on January 2007

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.

scientific article published on 16 September 2016

Metabolomic derangements are associated with mortality in critically ill adult patients

scientific article published on 30 January 2014

Mitochondria in lung biology and pathology: more than just a powerhouse

scientific article

Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy

scientific article published on 01 August 2019

Mitochondrial DNA in Sepsis

scientific article published on 27 May 2017

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

scientific article published on 29 July 2019

Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis

scientific article published on 05 December 2019

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

scientific article

Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1

scientific article published on 05 November 2020

NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis

scientific article published on 28 February 2017

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

scientific article published on 25 July 2016

Plasma mitochondrial DNA and metabolomic alterations in severe critical illness

scientific article published on 29 December 2018

Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system

scientific article published on December 2007

Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis

scientific article published in March 2003

Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity

scientific article published in September 2003

RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury.

scientific article

RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase.

scientific article published on 8 February 2018

Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation

scientific article

Targeting the mitogen-activated protein kinase-mediated vascular smooth muscle cell remodeling by angiotensin II

scientific article published on 01 March 2020

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

scientific article

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

scientific article

The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.

scientific article published in March 2009

Tin chloride pretreatment prevents renal injury in rats with ischemic acute renal failure

scientific article

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

scientific article

Upregulation of iNOS Protects Cyclic Mechanical Stretch-Induced Cell Death in Rat Aorta Smooth Muscle Cells

scientific article published on 17 November 2020

Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma

scientific article

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.

scientific article published on 25 June 2015

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