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List of works by Christina Yau

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

scientific article published in April 2018

A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer ⬇️

scientific article published on October 14, 2010

A phase 1b study of the Akt-inhibitor MK-2206 in combination with weekly paclitaxel and trastuzumab in patients with advanced HER2-amplified solid tumor malignancies.

scientific article published on 13 February 2016

A response to "Personalised medicine and population health: breast and ovarian cancer"

scientific article published on 27 February 2019

A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population

scientific article published on 31 July 2020

Abstract 2679: Integration of DNA repair deficiency and immune biomarkers to predict which early-stage triple-negative breast cancer patients are likely to respond to platinum-containing regimens vs. immunotherapy: The neoadjuvant I-SPY 2 trial

scholarly article

Abstract 2985: Predicting the impact of mutations in cancer using an integrated pathway approach

Abstract 3314: Normal breast tissue at risk for cancer development: A breast cancer initiating role for mammary adipocytes

scholarly article

Abstract 3361: A prescription for new trial designs for drug development focused on the neoadjuvant setting: Save lives, resources, and time

scholarly article

Abstract 5402: A new anticancer strategy based on inhibiting mitochondrial proline dehydrogenase (PRODH) and exploiting synthetic lethal interactions with p53 restoration and/or glutaminase (GLS1) inhibition

scientific article published on 05 August 2015

Activation of nuclear factor-kappaB (NFkappaB) identifies a high-risk subset of hormone-dependent breast cancers.

scientific article published on May 2005

Adaptive Randomization of Neratinib in Early Breast Cancer

scientific article published on July 2016

Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer

scientific article published on July 2016

Ageing, oxidative stress and cancer: paradigms in parallax

scientific article

Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers

scientific article

An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

scientific article published on 26 February 2016

An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk

scientific article published on January 2013

Androgen receptor gene expression in primary breast cancer

scientific article published on 10 December 2019

Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer

scientific article published on 08 August 2019

Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical T

scientific article published on 23 July 2020

Association of Residual Ductal Carcinoma In Situ With Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial

scientific article published in 2022

Biologic markers determine both the risk and the timing of recurrence in breast cancer ⬇️

scientific article published on May 20, 2011

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

scientific article published in April 2018

Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).

scientific article published on 25 December 2011

Clinically Meaningful Tumor Reduction Rates Vary by Prechemotherapy MRI Phenotype and Tumor Subtype in the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657) ⬇️

scientific article published on June 19, 2013

Co-expression modules identified from published immune signatures reveal five distinct immune subtypes in breast cancer

scientific article

Comparison of residual cancer burden, American Joint Committee on Cancer staging and pathologic complete response in breast cancer after neoadjuvant chemotherapy: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).

scientific article published on 2 June 2017

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer

scientific article published on 01 May 2020

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

scientific article

DGCR8 is essential for tumor progression following PTEN loss in the prostate

scientific article published on 23 July 2015

DNA defects, epigenetics, and gene expression in cancer-adjacent breast: a study from The Cancer Genome Atlas

scientific article

DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial

scientific article published on 25 August 2017

Discovery of internalizing antibodies to basal breast cancer cells

scientific article published on 28 December 2017

Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial

scientific article published on 13 February 2020

Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

scientific article

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL

scientific article published on 16 August 2018

FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index

scientific article published on 12 October 2015

Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL.

scientific article published on 23 December 2017

First Pregnancy Characteristics, Postmenopausal Breast Density, and Salivary Sex Hormone Levels in a Population at High Risk for Breast Cancer

scientific article

Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer

scientific article published on 05 October 2021

Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity

scientific article

Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers

scientific article published on 17 July 2008

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

scientific article published in April 2018

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

scientific article published in April 2018

High-Throughput Kinase Activity Mapping (HT-KAM) system: analysis of phospho-catalytic profiles

scholarly article

Impact of body mass index on pathological response after neoadjuvant chemotherapy: results from the I-SPY 2 trial

scholarly article published on 12 January 2024

Integrated genomic characterization of endometrial carcinoma ⬇️

scientific article published on May 2, 2013

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

scientific article published on August 2017

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

scientific article

Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer

scientific article published on 19 January 2018

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

scientific article published on 12 December 2014

Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer.

scientific article published on 8 September 2012

Local recurrence rates are low in high-risk neoadjuvant breast cancer in the I-SPY 1 Trial (CALGB 150007/150012; ACRIN 6657)

scientific article

Locally advanced breast cancers are more likely to present as Interval Cancers: results from the I-SPY 1 TRIAL (CALGB 150007/150012, ACRIN 6657, InterSPORE Trial) ⬇️

scientific article published on July 28, 2011

MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial

scientific article published on 07 February 2019

Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities

scientific article published on 03 June 2019

Mechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial

scientific article published on 02 October 2020

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

scientific article

Novel pathways associated with quinone-induced stress in breast cancer cells

scientific article published on January 2006

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

scientific article published on 24 October 2016

PRoBE the cloud toolkit: finding the best biomarkers of drug response within a breast cancer clinical trial

scientific article

Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL--CALGB 150007/150012, ACRIN 6657.

scientific article

Proteasome-regulated ERBB2 and estrogen receptor pathways in breast cancer

scientific article published on 28 March 2007

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

scientific article

Receptor activator of nuclear factor kappa B (RANK) expression in primary breast cancer correlates with recurrence-free survival and development of bone metastases in I-SPY1 (CALGB 150007/150012; ACRIN 6657).

scientific article published on 2 June 2017

Response to Carter et al

scientific article published on 05 March 2020

Rethinking the Standard for Ductal Carcinoma In Situ Treatment

scientific article published on 20 August 2015

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer ⬇️

scientific article published on March 17, 2011

Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

scientific article published on 29 May 2015

Synchronous Detection of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow Predicts Adverse Outcome in Early Breast Cancer

scientific article published on 29 May 2019

Tamoxifen therapy benefit for patients with 70-gene signature high and low risk

scientific article

Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition

scientific article published on 12 June 2019

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

scientific article published on 25 August 2017

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer

scientific article published on 24 February 2015

The WISDOM Personalized Breast Cancer Screening Trial: Simulation Study to Assess Potential Bias and Analytic Approaches

scientific article published on 01 October 2018

The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context

scientific article

Treatment and Long-Term Risks for Patients With a Diagnosis of Ductal Carcinoma In Situ-Reply.

scientific article

Use of 18F-FDG PET/CT as an Initial Staging Procedure for Stage II-III Breast Cancer: A Multicenter Value Analysis

scientific article published on 02 November 2020

Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades.

scientific article published on 29 June 2017

Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway

scientific article published on 2 February 2021

Young age, increased tumor proliferation and FOXM1 expression predict early metastatic relapse only for endocrine-dependent breast cancers ⬇️

scientific article published on January 12, 2011

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