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List of works by Hideshi Ishii

A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer: Research for Reprogramming of Cancer Cells by MicroRNAs.

scientific article published on 11 November 2014

A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones

scientific article published on 25 September 2018

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma

scientific article published on 04 July 2019

A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells

scientific article published on 11 February 2016

A case of lateral lymph node metastasis of submucosal rectal cancer

scientific article published on 01 November 2010

A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients

scientific article published on 20 November 2015

A long-term survival case of rectal cancer with Virchow's lymph node metastasis by multimodality therapy

scientific article published on November 1, 2010

ANXA9 gene expression in colorectal cancer: A novel marker for prognosis

scientific article

ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer.

scientific article

Abnormal expression of PFDN4 in colorectal cancer: a novel marker for prognosis

scientific article published on 15 June 2010

Adipose-derived mesenchymal stem cells and regenerative medicine

scientific article published on 03 March 2013

Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy

scientific article published on 22 February 2013

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice

scientific article published on 10 September 2019

Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer.

scientific article published on 26 March 2018

BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

scientific article

Biological and clinical availability of adipose-derived stem cells for pelvic dead space repair

scientific article

CD13 is a therapeutic target in human liver cancer stem cells

scientific article

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure

scientific article published on 16 October 2019

CD49f-positive cell population efficiently enriches colon cancer-initiating cells

scientific article published on 24 May 2013

CD90- (Thy-1-) high selection enhances reprogramming capacity of murine adipose-derived mesenchymal stem cells

scientific article published on 27 October 2013

Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges ⬇️

scientific article published on August 20, 2011

Cancer stem cells depend on their own niche

scientific article published in April 2013

Cancer stem cells of the digestive system

scientific article

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review).

scientific article published on September 2015

Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure.

scientific article published on 21 June 2018

Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo

scientific article

Cell-free culture conditioned medium elicits pancreatic β cell lineage-specific epigenetic reprogramming in mice.

scientific article published on 21 June 2018

Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

scientific article published on 3 December 2013

Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer

scientific article published on 29 July 2016

Clinical significance of ASB9 in human colorectal cancer.

scientific article

Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer

scientific article published on 27 April 2010

Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.

scientific article published on 16 September 2014

Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells

scientific article published on 17 January 2018

Correction: Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

scientific article published on 19 May 2017

Cyclin G2: A novel independent prognostic marker in pancreatic cancer

scientific article published on 2 September 2015

Decreased miR-340 expression in bone marrow is associated with liver metastasis of colorectal cancer.

scientific article published on 21 January 2014

Defined factors induce reprogramming of gastrointestinal cancer cells

scientific article

Depletion of JARID1B induces cellular senescence in human colorectal cancer

scientific article published on 25 January 2013

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

scientific article

Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells

scientific article

Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells

scientific article published on 14 February 2019

Distinct methylation levels of mature microRNAs in gastrointestinal cancers

scientific article published on 29 August 2019

Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance

scientific article published on 9 February 2012

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2

Effect of in vivo administration of reprogramming factors in the mouse liver

scientific article published on 20 June 2013

Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.

scientific article published on 15 July 2015

Emerging Methods for Preparing iPS Cells ⬇️

scientific article published on July 23, 2012

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis

scientific article published on 10 January 2018

Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer

scientific article published on 25 October 2009

Expression of CLDN1 in colorectal cancer: a novel marker for prognosis

scientific article published on 28 June 2011

FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma.

scientific article

Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model.

scientific article

Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.

scientific article

GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

scientific article published on 17 February 2018

Genetic alteration of stemness factors and p53 in mouse forestomach by chemical carcinogen-induced carcinogenesis ⬇️

scientific article published on March 13, 2012

Genetic susceptibility to gastrointestinal cancer: minireview of the genomewide studies

scientific article published on 13 May 2009

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

scientific article published on 24 June 2020

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.

scientific article

Genotoxic therapy stimulates error-prone DNA repair in dormant hepatocellular cancer stem cells ⬇️

scientific article published on March 22, 2012

High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer

scientific article published on 21 November 2016

Human colorectal CD24+ cancer stem cells are susceptible to epithelial-mesenchymal transition

scientific article

Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer ⬇️

scientific article published on January 24, 2012

Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer

scientific article published on 7 December 2017

Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system for proteasome activity

scientific article published on 24 September 2014

Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon

scientific article

Innovative cell-modifying technology targeting cancer stem cell

scientific article published on May 2013

Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

scientific article

Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line

scientific article

Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth

scientific article published on 21 May 2013

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer

scientific article

Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells

scientific article published on 7 April 2010

Low expression of the GOPC is a poor prognostic marker in colorectal cancer

scientific article published on 24 August 2017

MACC1 expression levels as a novel prognostic marker for colorectal cancer

scientific article published on 19 August 2014

Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating β-oxygenation pathway in colorectal cancer

scientific article published on 12 January 2015

Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer.

scientific article published on 07 December 2016

Micro-RNA-130a-3p Regulates Gemcitabine Resistance via PPARG in Cholangiocarcinoma

scientific article

MicroRNA miR-125b is a prognostic marker in human colorectal cancer

scientific article published on 10 March 2011

MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy

scientific article published on 22 September 2016

MicroRNA profiles involved in trifluridine resistance

scientific article published on 23 May 2017

MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells.

scientific article published on 10 February 2012

MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab

scientific article published on 10 January 2011

MicroRNA-372 is associated with poor prognosis in colorectal cancer

scientific article published on 26 March 2012

MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells

scientific article published on 13 May 2015

Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters

scientific article

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial-mesenchymal transition and radioresistance

scientific article published on 01 April 2019

Mitochondrial pyruvate carrier modulates the epithelial-mesenchymal transition in cholangiocarcinoma

scientific article published on 20 December 2017

Molecular biology of colon cancer

scientific article published on 01 April 2011

Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors.

scientific article

Novel drug discovery system for cancer stem cells in human squamous cell carcinoma of the esophagus

scientific article published on 30 December 2013

Novel therapeutic target for cancer stem cells in hepatocellular carcinoma ⬇️

scientific article published on November 1, 2012

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer

scientific article published on 21 December 2017

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

scientific article

Perspective beyond cancer genomics: bioenergetics of cancer stem cells

scientific article

Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells

scientific article published on 08 August 2018

Polyamine flux suppresses histone lysine demethylases and enhances expression in cancer stem cells

scientific article published on 13 November 2018

Postoperative complications in elderly patients with colorectal cancer: comparison of open and laparoscopic surgical procedures.

scientific article published on December 2009

Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer

scientific article published on 24 December 2015

Prognostic Impact of Peritumoral IL-17-Positive Cells and IL-17 Axis in Patients with Intrahepatic Cholangiocarcinoma

scientific article published on 31 July 2015

Properties and identification of cancer stem cells: a changing insight into intractable cancer

scientific article published on 26 June 2010

Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

scientific article published on 09 March 2015

RGS16 is a marker for prognosis in colorectal cancer.

scientific article published on 4 September 2009

Reprogramming of gastrointestinal cancer cells ⬇️

scientific article published on January 17, 2012

Reprogramming of mouse and human cells to pluripotency using mature microRNAs.

scientific article

Reprogramming using microRNA-302 improves drug sensitivity in hepatocellular carcinoma cells.

scientific article

Risk factors for postoperative delirium in elderly patients with colorectal cancer

scientific article published on 23 February 2010

Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer

scientific article

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

scientific article

SCRN1 is a novel marker for prognosis in colorectal cancer

scientific article

SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers

scientific article published on 22 November 2012

Significance of INHBA expression in human colorectal cancer

scientific article published on October 2013

Significance of Lgr5(+ve) cancer stem cells in the colon and rectum

scientific article published on 02 December 2010

Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer.

scientific article published on 22 April 2015

Surgically resected human tumors reveal the biological significance of the gastric cancer stem cell markers CD44 and CD26.

scientific article published on 20 March 2015

Susceptibility of pancreatic cancer stem cells to reprogramming

scientific article

TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer

scientific article

TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer.

scientific article published on 22 December 2009

The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer

scientific article published on 22 January 2015

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells

scientific article published on 7 December 2017

The future prospects and subject of the liver cancer stem cells study for the clinical application

scientific article

The importance of mitochondrial folate enzymes in human colorectal cancer.

scientific article published on 22 November 2016

The mitochondrial one-carbon metabolic pathway is associated with patient survival in pancreatic cancer

The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).

scientific article published on 20 February 2017

The significance of PITX2 overexpression in human colorectal cancer

scientific article (publication date: October 2011)

Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA

scientific article published on 24 January 2020

Transcriptomic study of dormant gastrointestinal cancer stem cells

scientific article

Visualization and characterization of cancer stem-like cells in cervical cancer

scientific article published on 24 September 2014

[CANCER REPROGRAMMING AND ITS CLINICAL APPLICABILITY].

scientific article published in November 2015

[Cancer stem cell]

scientific article published on 01 April 2011

[Cancer stem cells in solid tumors]

scientific article published on 01 December 2010

[Development of cancer stem cell research in gastrointestinal tumors]

scientific article published on 01 August 2010

[Esophageal cancer].

scientific article published in November 2012

[Metabolism enzyme controls cancer stemness].

scientific article

[Novel mechanism for invasion and metastasis involving metabolic enzymes in intractable cancer cells].

scientific article

[Perspectives on current status and future directions for cancer stem cells theory in gastrointestinal cancer].

scientific article

[Therapeutic Implication Targeting for Cancer Stem Cells].

scientific article published in September 2015

c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.

scientific article published on 24 May 2018

microRNA-181a is associated with poor prognosis of colorectal cancer

scientific article published on 26 September 2012

microRNA-based cancer cell reprogramming technology

scientific article published on 23 April 2012

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