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List of works by Irena Mlinarič-Raščan

5,10-Methylenetetrahydrofolate reductase (MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL).

scientific article published in October 2009

99mTc-labelled rituximab, a new non-Hodgkin's lymphoma imaging agent: first clinical experience

scientific article published on 01 December 2008

A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering

scientific article

A focused structure-activity relationship study of psoralen-based immunoproteasome inhibitors

scientific article published on 13 September 2019

A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types

scientific article published on 11 October 2007

ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics

scientific article published on 16 December 2019

Advanced therapies of skin injuries

scientific article published on 24 September 2015

Antioxidant and anti-inflammatory properties of 1,2,4-oxadiazole analogs of resveratrol.

scientific article published on 31 August 2015

Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy

scientific article

Azaphenylalanine-based serine protease inhibitors induce caspase-mediated apoptosis

scientific article

B cell receptor-mediated nuclear fragmentation proceeds in WEHI 231 cells in the absence of detectable DEVDase and FRase activity.

scientific article published in October 2003

Characterization of human lymphoblastoid cell lines as a novel in vitro test system to predict the immunotoxicity of xenobiotics

scientific article published on 24 December 2014

Chemo-sensitizing effects of EP4 receptor-induced inactivation of nuclear factor-κB.

scientific article published on 9 September 2014

Cinnamic acid derivatives induce cell cycle arrest in carcinoma cell lines.

scientific article published in August 2013

Design, synthesis and biological evaluation of novel desmuramyldipeptide analogs.

scientific article published on 27 May 2011

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

scientific article published on 21 December 2016

Discovery of Nanomolar Desmuramylpeptide Agonists of the Innate Immune Receptor Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (NOD2) Possessing Immunostimulatory Properties

scientific article published on 15 March 2018

Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening

scientific article published on 19 November 2014

EP4 receptor agonist L-902688 augments cytotoxic activities of ibrutinib, idelalisib, and venetoclax against chronic lymphocytic leukemia cells

scientific article published on 02 December 2020

EP4 receptor signalling in immature B cells involves cAMP and NF-κB dependent pathways ⬇️

scientific article published on March 22, 2012

Endocrine disrupting activities and immunomodulatory effects in lymphoblastoid cell lines of diclofenac, 4-hydroxydiclofenac and paracetamol

scientific article published on 16 May 2018

Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate

scientific article published on 02 September 2020

From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity

scientific article published in August 2014

Harnessing the untapped potential of nucleotide-binding oligomerization domain ligands for cancer immunotherapy

scientific article published on 13 December 2018

Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2.

scientific article published on 24 August 2016

Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides

scientific article published on 05 July 2012

Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond

scientific article

Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood

scientific article published in October 2009

Internucleosomal DNA cleavage in apoptotic WEHI 231 cells is mediated by a chymotrypsin-like protease

scientific article

MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females.

scientific article published on 11 September 2009

Methylation of Selenocysteine catalysed by Thiopurine S-Methyltransferase

article

Molecular docking revealed potential disruptors of glucocorticoid receptor-dependent reporter gene expression

scientific article published on 8 February 2014

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

scientific article published on April 2016

Novel N-amidinopiperidine-based proteasome inhibitor preserves dendritic cell functionality and rescues their Th1-polarizing capacity in Ramos-conditioned tumor environment.

scientific article published on 25 September 2014

Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT*3 alleles

article

PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy

scientific article published on 25 July 2016

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine.

scientific article published on 12 November 2009

Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies

scientific article

Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes

scientific article

Prostaglandin EP4 receptor enhances BCR-induced apoptosis of immature B cells ⬇️

scientific article published on May 10, 2011

Repositioning drugs for rare immune diseases: hopes and challenges for a precision medicine

scientific article published on 29 August 2017

Risk factors for symptomatic osteonecrosis in childhood ALL: A retrospective study of a Slovenian pediatric ALL population between 1970 and 2004.

scientific article published on 25 May 2016

S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts.

scientific article

Screening of bisphenol A, triclosan and paraben analogues as modulators of the glucocorticoid and androgen receptor activities

scientific article published on 2 September 2014

Selective Cytotoxicity of Amidinopiperidine Based Compounds Towards Burkitt’s Lymphoma Cells Involves Proteasome Inhibition ⬇️

scientific article published on July 30, 2012

Simultaneous quantification of intracellular concentrations of clinically important metabolites of folate-homocysteine cycle by LC-MS/MS

scientific article published on 24 July 2020

Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their <i>In Vivo</i> Adjuvant Activity

scientific article published on 27 May 2021

Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity

scientific article published on June 2014

Structural features and functional activities of benzimidazoles as NOD2 antagonists

scientific article published on 24 January 2020

Structural features of subtype-selective EP receptor modulators

scientific article

Structural requirements of acylated Gly-l-Ala-d-Glu analogs for activation of the innate immune receptor NOD2.

scientific article published on 16 March 2016

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase

scientific article published on 20 November 2015

Surface active stabilizer tyloxapol in colloidal dispersions exerts cytostatic effects and apoptotic dismissal of cells.

scientific article

Synthesis of conformationally constrained γ-D-glutamyl-meso-diaminopimelic acid derivatives as ligands of nucleotide-binding oligomerization domain protein 1 (Nod1).

scientific article published on 30 August 2013

The presence of the CYP11A1 (TTTTA)6 allele increases the risk of biochemical relapse in organ confined and low-grade prostate cancer

scientific article

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