List of works - Vega Masignani

4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp

scientific article published on 02 October 2020

A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells

scientific article

A universal vaccine for serogroup B meningococcus

scholarly article

An extended multi-locus molecular typing schema for Streptococcus pneumoniae demonstrates that a limited number of capsular switch events is responsible for serotype heterogeneity of closely related strains from different countries

scientific article

Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens

scientific article published in September 2004

Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6

scientific article published on 05 October 2019

Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae

scientific article

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

scientific article

Emerging experience with meningococcal serogroup B protein vaccines

scientific article

Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries

scientific article

Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components

scientific article

Exploring host-pathogen interactions through genome wide protein microarray analysis

scientific article

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined

scientific article published on 17 February 2016

Functional characterization of a monoclonal antibody epitope using a lambda phage display-deep sequencing platform.

scientific article

Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome"

scientific article

Genome-based approaches to develop vaccines against bacterial pathogens

scientific article

Genome-based vaccine development: a short cut for the future

scientific article published on January 2009

Genome‑based vaccine development: A short cut for the future ⬇️

scientific article published on May 1, 2008

HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells

scientific article published on 12 March 2009

Identification of a Monoclonal Antibody Against Pneumococcal Pilus 1 Ancillary Protein Impairing Bacterial Adhesion to Human Epithelial Cells

scientific article published on 23 September 2015

Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization

scientific article published on June 2007

Identification of a universal Group B streptococcus vaccine by multiple genome screen

scientific article

Immune responses to pneumococcal pilus RrgA and RrgB antigens and their relationship with pneumococcal carriage in humans

scientific article published on 6 February 2014

Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressing Streptococcus pneumoniae populations ⬇️

scientific article published on December 30, 2011

In silico identification of novel bacterial ADP-ribosyltransferases

scientific article published on April 2004

Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54

scientific article published on 03 April 2019

Meningococcal B vaccine (4CMenB): the journey from research to real world experience

scientific article published on 05 December 2018

NadA, a novel vaccine candidate of Neisseria meningitidis

scientific article

NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis

scientific article published in November 2003

Neisseria adhesin A variation and revised nomenclature scheme

scientific article published on 7 May 2014

Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells.

scientific article published on February 2005

Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.

scientific article

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells

scientific article

Opinion: Cell entry machines: a common theme in nature?

scientific article published on 01 April 2005

Phage display revisited: Epitope mapping of a monoclonal antibody directed against Neisseria meningitidis adhesin A using the PROFILER technology

scientific article published on 10 March 2016

Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A

scientific article

Reverse vaccinology: a genome-based approach for vaccine development

scientific article

RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies

scientific article published on 14 November 2011

SARS--beginning to understand a new virus

scientific article published on December 2003

Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis

scientific article

Sortase A confers protection against Streptococcus pneumoniae in mice

scientific article published on 11 May 2009

Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related

scientific article published in March 2008

Streptococcus pneumoniae pilus subunits protect mice against lethal challenge

scientific article published on 4 December 2006

Structural and functional characterization of the Streptococcus pneumoniae RrgB pilus backbone D1 domain

scientific article

Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein

scientific article published on 26 June 2019

Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096

scientific article published on 18 April 2022

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

scientific article

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody

scientific article

Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus pneumoniae Pilus

scientific article

The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern

scientific article (publication date: 2011)

The microbial pan-genome

scientific article

The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials

scientific article

The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies

scientific article published in February 2005

The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo

scientific article

Towards a universal group B Streptococcus vaccine using multistrain genome analysis

scientific article published on October 2006

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870

scientific article

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

scientific article published on 08 January 2014

Vir90, a virulence-activated gene coding for a Bordetella pertussis iron-regulated outer membrane protein

scientific article published on July 2003

List of works by Vega Masignani

4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp

A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells

A universal vaccine for serogroup B meningococcus

An extended multi-locus molecular typing schema for Streptococcus pneumoniae demonstrates that a limited number of capsular switch events is responsible for serotype heterogeneity of closely related strains from different countries

Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens

Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6

Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

Emerging experience with meningococcal serogroup B protein vaccines

Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries

Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components

Exploring host-pathogen interactions through genome wide protein microarray analysis

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined

Functional characterization of a monoclonal antibody epitope using a lambda phage display-deep sequencing platform.

Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome"

Genome-based approaches to develop vaccines against bacterial pathogens

Genome-based vaccine development: a short cut for the future

Genome‑based vaccine development: A short cut for the future ⬇️

HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells

Identification of a Monoclonal Antibody Against Pneumococcal Pilus 1 Ancillary Protein Impairing Bacterial Adhesion to Human Epithelial Cells

Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization

Identification of a universal Group B streptococcus vaccine by multiple genome screen

Immune responses to pneumococcal pilus RrgA and RrgB antigens and their relationship with pneumococcal carriage in humans

Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressing Streptococcus pneumoniae populations ⬇️

In silico identification of novel bacterial ADP-ribosyltransferases

Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54

Meningococcal B vaccine (4CMenB): the journey from research to real world experience

NadA, a novel vaccine candidate of Neisseria meningitidis

NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis

Neisseria adhesin A variation and revised nomenclature scheme

Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells.

Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells

Opinion: Cell entry machines: a common theme in nature?

Phage display revisited: Epitope mapping of a monoclonal antibody directed against Neisseria meningitidis adhesin A using the PROFILER technology

Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A

Reverse vaccinology: a genome-based approach for vaccine development

RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies

SARS--beginning to understand a new virus

Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis

Sortase A confers protection against Streptococcus pneumoniae in mice

Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related

Streptococcus pneumoniae pilus subunits protect mice against lethal challenge

Structural and functional characterization of the Streptococcus pneumoniae RrgB pilus backbone D1 domain

Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein

Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody

Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus pneumoniae Pilus

The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern

The microbial pan-genome

The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials

The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies

The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo

Towards a universal group B Streptococcus vaccine using multistrain genome analysis

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

Vir90, a virulence-activated gene coding for a Bordetella pertussis iron-regulated outer membrane protein