List of works - Michael Piatak

A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants

scientific article

A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge

scientific article

A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

scientific article

A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo

scientific article published on 10 June 2013

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV

scientific article

A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.

scientific article

A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation

scientific article

A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge

scientific article

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

scientific article (publication date: August 2015)

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

scientific article

ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge

scientific article

Absence of detectable HIV-1 viremia after treatment cessation in an infant

scientific article

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques

scientific article

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

scientific article

An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques

scientific article published on 9 June 2017

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

scientific article

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

scientific article

CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection

scientific article (publication date: February 2015)

Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.

scientific article

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

scientific article published on 8 February 2016

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

scientific article published on January 2016

Distinct phenotype, longitudinal changes of numbers and cell-associated virus in blood dendritic cells in SIV-infected CD8-lymphocyte depleted macaques

scientific article

Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection

scientific article

Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques

scientific article

Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus

scientific article

Effects of treatment with suppressive combination antiretroviral drug therapy and the histone deacetylase inhibitor suberoylanilide hydroxamic acid; (SAHA) on SIV-infected Chinese rhesus macaques

scientific article (publication date: 2014)

Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity

scientific article

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

scientific article published on 28 December 2015

Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge

scientific article

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

scientific article (publication date: 2014)

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

scientific article published on 12 July 2018

HIV-1-induced AIDS in monkeys

scientific article

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

scientific article

HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infection

scientific article (publication date: December 2014)

IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates

scientific article

Immune clearance of highly pathogenic SIV infection

scientific article

Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239

scientific article

Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.

scientific article

Improved single-copy assays for quantification of persistent HIV-1 viremia in patients on suppressive antiretroviral therapy

scientific article

In vivo binding and retention of CD4-specific DARPin 57.2 in macaques

scientific article (publication date: 2010)

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1 ⬇️

scientific article

Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.

scientific article

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

scientific article

Live simian immunodeficiency virus vaccine correlate of protection: local antibody production and concentration on the path of virus entry

scientific article

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge

scientific article (publication date: 2013)

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

scientific article

Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis

scientific article

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

scientific article

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates

scientific article published on 14 September 2016

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

scientific article

Persistence of viral reservoirs in multiple tissues after antiretroviral therapy suppression in a macaque RT-SHIV model

scientific article (publication date: 2013)

PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

scientific article (publication date: 2016)

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

scientific article

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

scientific article published on 13 May 2017

Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate

scientific article

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

scientific article published on 19 October 2012

Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides

scientific article

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy

scientific article

TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection

scientific article

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

scientific article published on December 2013

The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection

scientific article

Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239.

scientific article published on December 2009

Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques

scientific article

Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239

scientific article

Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques

scientific article

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

scientific article

Vaccine-induced CD8+ T cells control AIDS virus replication

scientific article published on 30 September 2012

Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge

scientific article published on 29 April 2009

List of works by Michael Piatak

A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants

A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge

A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV

A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.

A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation

A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge

Absence of detectable HIV-1 viremia after treatment cessation in an infant

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection

Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

Distinct phenotype, longitudinal changes of numbers and cell-associated virus in blood dendritic cells in SIV-infected CD8-lymphocyte depleted macaques

Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection

Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques

Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus

Effects of treatment with suppressive combination antiretroviral drug therapy and the histone deacetylase inhibitor suberoylanilide hydroxamic acid; (SAHA) on SIV-infected Chinese rhesus macaques

Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

HIV-1-induced AIDS in monkeys

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infection

IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates

Immune clearance of highly pathogenic SIV infection

Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239

Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.

Improved single-copy assays for quantification of persistent HIV-1 viremia in patients on suppressive antiretroviral therapy

In vivo binding and retention of CD4-specific DARPin 57.2 in macaques

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1 ⬇️

Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

Live simian immunodeficiency virus vaccine correlate of protection: local antibody production and concentration on the path of virus entry

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

Persistence of viral reservoirs in multiple tissues after antiretroviral therapy suppression in a macaque RT-SHIV model

PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy

TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection

Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239.

Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques

Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239

Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

Vaccine-induced CD8+ T cells control AIDS virus replication

Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge