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List of works by Kazunari Taira

A Direct and efficient synthesis method for dumbell-shaped linear DNA using PCR in vitro ⬇️

scientific article published on 01 January 2003

A fast, simple method for screening radiation susceptibility genes by RNA interference

article

A functional gene discovery in cell differentiation by hybrid ribozyme and siRNA libraries

scientific article published on 01 January 2002

A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries

scientific article published in August 2002

A major functional difference between the mouse and human ARF tumor suppressor proteins

scientific article published on 26 July 2002

A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.

scientific article published in September 2005

A novel fluorescent nonnatural amino acid that can be incorporated into a specific position of streptavidin

scientific article published on 01 January 2002

A novel maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article published on 23 March 2004

A novel putative collaborator of p19ARF

scientific article

A novel strategy by the action of ricin that connects phenotype and genotype without loss of the diversity of libraries.

scientific article published in January 2002

A reappraisal, based on (31)P NMR, of the direct coordination of a metal ion with the phosphoryl oxygen at the cleavage site of a hammerhead ribozyme

scientific article published on 01 July 2002

A small modulatory dsRNA specifies the fate of adult neural stem cells

scientific article

A system based on specific protein-RNA interactions for analysis of target protein-protein interactions in vitro: successful selection of membrane-bound Bak-Bcl-xL proteins in vitro

scientific article

A20 is a negative regulator of IFN regulatory factor 3 signaling.

scientific article published on February 2005

Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells

scientific article published on 26 January 2004

Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

scientific article published on July 2004

Allosterically controllable maxizymes for molecular gene therapy.

scientific article

Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control

scientific article

An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?

scientific article

An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

scientific article

Analysis of a mitochondrial apoptotic pathway using Bid-targeted ribozymes in human MCF7 cells in the absence of a caspase-3-dependent pathway

scientific article published on April 2003

Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library

scientific article published on 21 April 2005

Analysis of processing-defective variants of human tRNA(Val) ⬇️

scientific article published on 01 January 2003

Analysis of the conserved P9-G10.1 metal-binding motif in hammerhead ribozymes with an extra nucleotide inserted between A9 and G10.1 residues

scientific article published in October 2004

Analysis on a cooperative pathway involving multiple cations in hammerhead reactions

scientific article published on 01 October 2004

Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis AttenuatesIn vivoTumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent Manner

article

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

scientific article

Cancer gene validation using ribozymes and macroarray ⬇️

scientific article published on 01 January 2003

Cancer-derived VEGF plays no role in malignant ascites formation in the mouse

scientific article

Cell migration and metastasis as targets of small RNA-based molecular genetic analyses.

scientific article

Chemistry-based RNA technologies: demonstration of usefulness of libraries of ribozymes and short hairpin RNAs (shRNAs).

scientific article

Cleavage of an inaccessible site by the maxizyme with two independent binding arms: an alternative approach to the recruitment of RNA helicases.

scientific article

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article

Comparison of metal-ion-dependent cleavages of RNA by a DNA enzyme and a hammerhead ribozyme

scientific article published on 01 January 2002

Comparison of the Suppressive Effects of Antisense Oligonucleotides and siRNAs Directed Against the Same Targets in Mammalian Cells

scientific article published on 01 February 2003

Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation

scientific article

Construction of an allosteric trans-maxizyme targeting for two distinct oncogenes

scientific article published on 01 January 2002

Construction of microRNA-containing vectors for expression in mammalian cells

scientific article

Control of siRNA expression using the Cre-loxP recombination system.

scientific article

Control of siRNA expression utilizing Cre-loxP recombination system

scientific article published on 01 January 2003

Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones

scientific article published on 01 October 2005

Correlation of structure and activity of short hairpin RNA

scientific article published on 01 January 2006

Crystallographic snapshots of an entire reaction cycle for a retaining xylanase from Streptomyces olivaceoviridis E-86

scientific article

Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival

scientific article published on May 2006

Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4.

scientific article published on 23 November 2005

Design of efficient DNAzymes against muscle AChR alpha-subunit cRNA in vitro and in HEK 293 cells.

scientific article published on 14 October 2005

Design of hammerhead ribozymes that cleave murine Sry mRNA in vitro and in vivo

scientific article published on 17 November 2005

Detection of a proton-transfer process by kinetic solvent isotope effects in NH(4)(+)-mediated reactions catalyzed by a hammerhead ribozyme

scientific article published on 01 April 2002

Determination of the role of DDX3 a factor involved in mammalian RNAi pathway using an shRNA-expression library

scientific article

Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease

scientific article published in January 2005

Down-regulation of endogenous Wt1 expression by Sry transgene in the murine embryonic mesonephros-derived M15 cell line

scientific article published on 27 March 2006

Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi.

scientific article published in January 2006

Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs

scientific article published on October 2002

Effects on RNAi of the tight structure, sequence and position of the targeted region.

scientific article published on 03 February 2004

Efficient inhibition of β‐secretase gene expression in HEK293 cells by tRNAVal‐driven and CTE‐helicase associated hammerhead ribozymes ⬇️

scientific article published on October 1, 2003

Emerging technologies: trendy RNA tools for aging research

scientific article published in August 2004

Enhancement in the cleavage activity of a hammerhead ribozyme by cationic comb-type polymers and an RNA helicase in vitro

scientific article published in May 2002

Erratum to “siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme” [Biochem. Biophys. Res. Commun. 314 (2004) 283–291]

scholarly article published in Biochemical and Biophysical Research Communications

Erratum: Corrigendum: Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

scientific article published in Nature

Erratum: corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

scientific article published in Nature

Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA.

scientific article published on 7 November 2005

Establishment of Stable hFis1 Knockdown Cells with an siRNA Expression Vector

scientific article published on 01 October 2004

Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme

scientific article

Exploration of human miRNA target genes in neuronal differentiation

scientific article published on January 2005

Expression of siRNA from a single transcript that includes multiple ribozymes in mammalian cells

scientific article published on January 2003

Functional gene discovery using hybrid ribozyme libraries

scientific article published in January 2004

Functional gene-discovery systems based on libraries of hammerhead and hairpin ribozymes and short hairpin RNAs

scientific article

GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements.

scientific article published in July 2004

Gene discovery by ribozyme and siRNA libraries

scientific article published in May 2005

Gene discovery system with randomized ribozyme libraries

scientific article published on March 1, 2003

Generation of an shRNAi expression library against the whole human transcripts

scientific article

Genome-wide application of RNAi to the discovery of potential drug targets

scientific article published on 22 August 2005

Genome-wide sreening by using small-interfering RNA expression libraries

scientific article

Hammerhead ribozyme-based target discovery

scientific article

Helicase-attached novel hybrid ribozymes

scientific article published in January 2004

Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells

retracted scientific article

Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.

scientific article

Identification of AP-2-regulated genes by macroarray profiling of gene expression in human A375P melanoma

scientific article published on 01 January 2002

Identification of a caspase 3-independent role of pro-apoptotic factor Bak in TNF-alpha-induced apoptosis

scientific article published on September 2002

Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors

scientific article

Identification of functional genes by libraries of ribozymes and siRNAs ⬇️

scientific article published on 01 January 2003

Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase

scientific article

Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes ⬇️

scientific article published on April 28, 2003

Identification of genes responsible for cell migration by a library of randomized ribozymes.

scientific article

Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries

article

Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes

scientific article

Identification of the metal ion binding site on an RNA motif from hammerhead ribozymes using (15)N NMR spectroscopy

scientific article published in May 2002

Imminent approaches towards molecular interventions in ageing.

scientific article

Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme

scientific article published on 09 August 2004

Importance of magnesium ions in the mechanism of catalysis by a hammerhead ribozyme: strictly linear relationship between the ribozyme activity and the concentration of magnesium ions

scientific article published on 01 September 2003

In vivo gene discovery system with libraries of randomized ribozymes

scientific article

Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

retracted scientific article published on 15 August 2004

Induction of apoptosis in HeLa cells with siRNA expression vector targeted against bcl-2

scientific article published on 01 January 2002

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.

scientific article published on August 2004

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

scientific article

Inhibition of type I procollagen production by tRNAVal CTE-HSP47 ribozyme

scientific article published on 01 September 2003

Introduction of short interfering RNA to silence endogenous E-selectin in vascular endothelium leads to successful inhibition of leukocyte adhesion.

scientific article published on October 2003

Involvement of template-activating factor I/SET in transcription of adenovirus early genes as a positive-acting factor

scientific article published on January 2006

Know-how of RNA interference and its applications in research and therapy

scientific article published in September 2004

LIM kinase-2 targeting as a possible anti-metastasis therapy

scientific article

Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids

scientific article

Leucyl/phenylalanyl (L/F)-tRNA-protein transferase-mediated N-terminal specific labelling of a protein in vitro

scientific article published on 01 January 2003

Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis

scholarly article

Maxizyme technology

scientific article published in January 2004

Maxizymes and small hairpin-type RNAs that are driven by a tRNA promoter specifically cleave a chimeric gene associated with leukemia in vitro and in vivo ⬇️

scientific article published on October 15, 2003

Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity

scientific article

Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations.

scientific article published in January 2005

Modified peptide selection in vitro by introduction of a protein-RNA interaction

scientific article published in December 2003

Modulation of beta-secretase gene expression by action of catalytic nucleic acids

scientific article published on 01 January 2002

Molecular design and delivery of siRNA.

scientific article published on January 2006

Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates

scientific article published on December 2003

Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation

scientific article

Mortalin: present and prospective

scientific article

Mouse microRNA-23b regulates expression of Hes1 gene in P19 cells

scientific article published in January 2004

Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.

scientific article published on June 2006

NMR spectroscopic analyses of functional nucleic acids-metal interaction and their solution structure analyses.

scientific article published on January 2005

NMR spectroscopic investigations of the roles of the metal ion at A9/G10.1 site in hammerhead ribozymes

scientific article published on 01 January 2003

NMR-based reappraisal of the coordination of a metal ion at the pro-Rp oxygen of the A9/G10.1 site in a hammerhead ribozyme

scientific article published on 01 December 2004

Nature of the chemical bond formed with the structural metal ion at the A9/G10.1 motif derived from hammerhead ribozymes

scientific article published in January 2004

Novel Methods for Expressing RNA Interference in Human Cells

scientific article published on 01 January 2005

Novel approach for linking genotype to phenotype in vitro by exploiting an extremely strong interaction between RNA and protein

scientific article published on April 2002

Novel method for selection of tRNA-driven ribozymes with enhanced stability in mammalian cells

scientific article published on 01 October 2002

Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells.

scientific article published in July 2004

Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts

scientific article published on 01 May 2003

Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma

scientific article published on 7 March 2002

Overexpression of Dicer enhances RNAi-mediated gene silencing by short-hairpin RNAs (shRNAs) in human cells

scientific article published in January 2004

Phosphorylation at 5' end of guanosine stretches inhibits dimerization of G-quadruplexes and formation of a G-quadruplex interferes with the enzymatic activities of DNA enzymes

scientific article published on 27 August 2004

Position-specific incorporation of a fluorophore-quencher pair into a single streptavidin through orthogonal four-base codon/anticodon pairs

scientific article published in December 2002

Proteomic analysis of the TGF-beta signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression.

scientific article published on May 2004

Quantum dots in bio-imaging: Revolution by the small

scientific article

RNAi expression vectors in mammalian cells

scientific article published on January 2004

RNAi expression vectors in plant cells

scientific article published in January 2004

RNAi-mediated specific gene silencing and its application to medical treatments of viral infectious disease

scientific article

Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells.

scientific article published on April 2004

Retraction Note to: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells ⬇️

scientific article published on November 6, 2003

Retraction: Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries

scientific article published on 01 September 2006

Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo

scientific article published on August 2002

Ribosome-inactivation display system

scientific article published in January 2007

Ribozyme expression systems

scientific article published in January 2004

Ribozymes: applications to functional analysis and gene discovery.

scientific article published in August 2004

Screening of siRNA target sequences by using fragmentized DNA.

scientific article

Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA.

scientific article published in July 2004

Sequence-specific interference by small RNAs derived from adenovirus VAI RNA

scientific article

Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells

scientific article

Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components

scientific article

Site-directed incorporation of non-natural amino acid into Streptomyces xylanase.

scientific article published on January 2004

Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta.

scientific article

Small-interfering-RNA expression in cells based on an efficiently constructed dumbbell-shaped DNA.

scientific article published in June 2004

Specific 3'-terminal modification of DNA with a novel nucleoside analogue that allows a covalent linkage of a nuclear localization signal and enhancement of DNA stability

scientific article

Stimulatory effect of an indirectly attached RNA helicase-recruiting sequence on the suppression of gene expression by antisense oligonucleotides.

scientific article

Strategies for generation of an siRNA expression library directed against the human genome.

scientific article published in January 2003

Synthesis of a novel histidine analogue and its efficient incorporation into a protein in vivo.

scientific article published in September 2003

TRAIL-induced cell death cooperates with IFN-γ activation in the graft-versus-tumor effect against colon tumors

scientific article published on 01 May 2006

Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes

scientific article

The NRSE smRNA specifies the fate of adult hippocampal neural stem cells

scientific article published in January 2005

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

scientific article

Theoretical study about remarkable stability of guanine tetramer

scientific article published on 01 January 2004

Theoretical study of substitution effect of the hydrogen bond stability of 9-methylguanine derivatives and 1-methylcytosine

scientific article published on 01 January 2002

Transcriptional gene silencing by short interfering RNAs.

scientific article

Transgenic Small Interfering RNA Halts Amyotrophic Lateral Sclerosis in a Mouse Model

scientific article published in Journal of Biological Chemistry

Transglutaminase-mediated N- and C-terminal fluorescein labeling of a protein can support the native activity of the modified protein

scientific article published on 12 January 2004

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

scientific article published in May 2002

Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation.

scientific article published on 24 September 2004

Use of a ribozyme library for validation of gene functions and cellular pathways ⬇️

scientific article published on 01 January 2003

Vector-Based in Vivo RNA Interference: Dose- and Time-Dependent Suppression of Transgene Expression

scientific article published on 10 November 2003

Vectors for RNA interference

scientific article published in August 2004

World of small RNAs: from ribozymes to siRNA and miRNA.

scientific article published on March 2004

[Basic research on and application of RNA interference]

scientific article published on 01 June 2004

[In vitro selection for protein: linkage between genotype and phenotype].

scientific article

[Target site independent cleavage by RNA protein hybrid ribozyme]

scientific article published on 01 August 2003

[Visualization of activated caspase 8 using fluorescent resonance energy transfer (FRET)].

scientific article

p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells

scientific article published on December 2005

siRNA becomes smart and intelligent.

scientific article published in August 2005

siRNA induced transcriptional gene silencing in mammalian cells

scientific article

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme

scientific article published on January 2004

siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells

scientific journal article

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