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List of works by Leire Garate

Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia

scientific article

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism

scientific article published on 6 September 2017

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

scientific article published on 20 August 2020

Contrasting biological features in morphologically cryptic Mediterranean sponges

scientific article published on 29 June 2017

CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia

scientific article published on 01 August 2006

Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces

scientific article published on 19 July 2018

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy

scientific article published on 19 July 2018

Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells

scientific article published on 6 February 2012

Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth

scientific article

Downregulation of DBC1 expression in acute lymphoblastic leukaemia is mediated by aberrant methylation of its promoter

scientific article published on 01 July 2006

Endosymbiotic calcifying bacteria across sponge species and oceans

scientific article published on 06 March 2017

Epigenetic regulation of PRAME gene in chronic myeloid leukemia

scientific article published on 26 March 2007

Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia

scientific article published on 5 December 2006

Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia

scientific article published on February 2007

Epigenetic regulation of microRNAs in acute lymphoblastic leukemia

scientific article

Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia

scientific article

Identifying Lethal Dependencies with HUGE Predictive Power

scientific article published in 2022

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer.

scientific article published on 30 October 2017

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

scientific article published on 03 July 2019

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response

article

MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations

scientific article published on September 2009

Molecular phylogenies confirm the presence of two cryptic Hemimycale species in the Mediterranean and reveal the polyphyly of the genera Crella and Hemimycale (Demospongiae: Poecilosclerida).

scientific article

Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia

scientific article published in November 2005

Redescription and establishment of a holotype and three paratypes for the species Hemimycale mediterranea sp. nov.

scientific article

Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia

scientific article published on 04 September 2007

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome.

scientific article published on 27 December 2017

Showcasing the role of seawater in bacteria recruitment and microbiome stability in sponges

scientific article published in Scientific Reports

TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia

scientific article

WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia

scientific article published on December 2007

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