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List of works by Jeffrey A Sosman

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts: National Harbor, MD, USA. 9-13 November 2016.

scientific article published on 8 December 2016

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance

scientific article

A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors

scientific article published on 21 September 2016

Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms

scientific article

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

scientific article

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.

scientific article published on 12 February 2018

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors

scientific article

Beyond histology: translating tumor genotypes into clinically effective targeted therapies

scientific article

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

scientific article

Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach

scientific article

Combined BRAF (Dabrafenib) and MEK inhibition (Trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor

scientific article

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

scientific article

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial

scientific article published on 18 June 2014

Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel

scientific article

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study

scientific article published on 15 December 2017

Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients with BRAF V600-mutated Metastatic Melanoma

scientific article published on 01 March 2019

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

scientific article

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

scientific article (publication date: 26 August 2010)

Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference

scientific article published on January 2007

Ipilimumab Therapy in Patients With Advanced Melanoma and Preexisting Autoimmune Disorders.

scientific article

Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression

scientific article published on 13 May 2015

Marked, homogeneous, and early [18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma.

scientific article

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

scientific article

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

scientific article

Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

scientific article

Overall Survival and Durable Responses in Patients With BRAF V600-Mutant Metastatic Melanoma Receiving Dabrafenib Combined With Trametinib.

scientific article

Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma

scientific article

Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors

scientific article

Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor

scientific article published on 17 December 2012

Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors

scientific article published on April 2012

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

scientific article published on January 2012

Relationship between physician-adjudicated adverse events and patient-reported health-related quality of life in a phase II clinical trial (NCT01143402) of patients with metastatic uveal melanoma

scientific article published on 05 December 2016

Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

scientific article (publication date: 2012)

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

scientific article

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

scientific article

The state of melanoma: challenges and opportunities

scientific article

Two phase 2 trials of the novel Akt inhibitor perifosine in patients with advanced renal cell carcinoma after progression on vascular endothelial growth factor-targeted therapy ⬇️

scientific article published on 06 June 2012

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

scientific article published on 4 April 2016

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