List of works by Marilena Manea

A new daunomycin-peptide conjugate: synthesis, characterization and the effect on the protein expression profile of HL-60 cells in vitro.

scientific article

Anthracycline-GnRH derivative bioconjugates with different linkages: synthesis, in vitro drug release and cytostatic effect

scientific article

Antibody recognition and conformational flexibility of a plaque-specific beta-amyloid epitope modulated by non-native peptide flanking regions

scientific article

Antigen-bound and free β-amyloid autoantibodies in serum of healthy adults

scientific article

Correction: Antigen-Bound and Free β-Amyloid Autoantibodies in Serum of Healthy Adults.

scientific article published in November 2012

Design, structural, and immuno-analytical properties of antigenic bioconjugates comprising a beta-amyloid-plaque specific epitope

scientific article

Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug-bioconjugates containing GnRH-III as a targeting moiety

scientific article published on 20 April 2011

Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction

scientific article published on 13 July 2016

Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-III conjugate as a potential anticancer drug

scientific article published on April 2009

Drug targeting to decrease cardiotoxicity - determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

scientific article published on 28 June 2018

Efficient synthesis of an (aminooxy) acetylated-somatostatin derivative using (aminooxy)acetic acid as a 'carbonyl capture' reagent

scientific article published on 2 September 2010

Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates

scientific article published on 23 August 2012

Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4.

scientific article published on 23 June 2011

Epitope structure and binding affinity of single chain llama anti-β-amyloid antibodies revealed by proteolytic excision affinity-mass spectrometry

scientific article

Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks.

scientific article published in June 2009

GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate

scientific article published on 16 March 2012

Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies

scientific article published on 03 January 2013

Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry

scientific article published in January 2005

Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice

scientific article published on 05 May 2016

In vitro degradation and antitumor activity of oxime bond-linked daunorubicin-GnRH-III bioconjugates and DNA-binding properties of daunorubicin-amino acid metabolites

scientific article published on 16 October 2010

In-vivo antitumour effect of daunorubicin-GnRH-III derivative conjugates on colon carcinoma-bearing mice

scientific article published in January 2012

Increased levels of antigen-bound β-amyloid autoantibodies in serum and cerebrospinal fluid of Alzheimer's disease patients

scientific article published on 18 July 2013

Interaction of beta-amyloid(1-40) peptide with pairs of metal ions: An electrospray ion trap mass spectrometric model study.

scientific article

Interaction structure of the complex between neuroprotective factor humanin and Alzheimer's β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling

scientific article

Luteinizing hormone-releasing hormone antagonists

scientific article published on December 2009

Mass spectrometric approaches for elucidation of antigenantibody recognition structures in molecular immunology

scientific article published in January 2007

Mass spectrometric identification of the trypsin cleavage pathway in lysyl-proline containing oligotuftsin peptides.

scientific article published in April 2007

Modification of daunorubicin-GnRH-III bioconjugates with oligoethylene glycol derivatives to improve solubility and bioavailability for targeted cancer chemotherapy.

scientific article published in May 2015

Molecular characterization of the β-amyloid(4-10) epitope of plaque specific Aβ antibodies by affinity-mass spectrometry using alanine site mutation.

scientific article published in January 2018

New derivatives of GnRH as potential anticancer therapeutic agents

scientific article published on January 2008

New insights into coenzyme A interaction with mercury ions provided by mass spectrometric and circular dichroism spectroscopic approaches.

scientific article

Oxime bond-linked daunorubicin-GnRH-III bioconjugates exert antitumor activity in castration-resistant prostate cancer cells via the type I GnRH receptor.

scientific article published on 24 October 2014

Polypeptide conjugates comprising a beta-amyloid plaque-specific epitope as new vaccine structures against Alzheimer's disease.

scientific article

Protein expression profile of HT-29 human colon cancer cells after treatment with a cytotoxic daunorubicin-GnRH-III derivative bioconjugate

scientific article (publication date: 2014)

Receptor-mediated tumor targeting based on peptide hormones

scientific article published on January 2010

Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives

scientific article

Synthesis and antibody recognition of cyclic epitope peptides, together with their dimer and conjugated derivatives based on residues 9-22 of herpes simplex virus type 1 glycoprotein D.

scientific article published on April 2009

Synthesis and structural characterization of bioactive peptide conjugates using thioether linkage approaches.

scientific article published in December 2004

Synthesis, enzymatic stability and in vitro cytostatic effect of Daunorubicin-GnRH-III derivative dimers

scientific article published on 31 January 2013

Synthesis, solution conformation, and antibody recognition of oligotuftsin-based conjugates containing a beta-amyloid(4-10) plaque-specific epitope

scientific article published in July 2005

Targeting hormonal signaling pathways in castration resistant prostate cancer.

scientific article published on January 2014

Zinc binding agonist effect on the recognition of the beta-amyloid (4-10) epitope by anti-beta-amyloid antibodies

scientific article

[Studying the tumor growth inhibitory effect of modified GnRH-III-anthracycline bioconjugates in subcutaneous vs. orthotopic models in vivo]

scientific article published on 15 October 2015

lGnRH-III -- a promising candidate for anticancer drug development

scientific article published on April 2013

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