List of works by Dave Sprengers

Action and clinical significance of CCAAT/enhancer-binding protein delta in hepatocellular carcinoma

scientific article published on 01 March 2019

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

scientific article published on 04 December 2012

Alpha-galactosylceramide in chronic hepatitis B infection: results from a randomized placebo-controlled Phase I/II trial.

scientific article published on January 2009

Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans.

scientific article

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-infiltrating T cells in Hepatocellular Carcinomas

scientific article published on 22 June 2017

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer.

scientific article published on 25 April 2018

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling

scientific article published on 13 November 2016

Coarse vs. fine needle aspiration biopsy

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV.

scientific article

Critical Role for CD1d-Restricted Invariant NKT Cells in Stimulating Intrahepatic CD8 T-Cell Responses to Liver Antigen

article

Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication

scientific article published on 29 February 2016

Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid.

scientific article published on 13 October 2015

Distinct Antiviral Potency of Sofosbuvir Against Hepatitis C and E Viruses.

scientific article published in November 2016

Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells

scientific article

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury

scientific article published on 14 July 2017

Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis

scientific article published on 18 May 2020

Evidence of good prognosis of hepatocellular adenoma in post-menopausal women

scientific article published on 11 August 2016

Factors associated with ethnical disparity in overall survival for patients with hepatocellular carcinoma

scientific article published on 20 January 2017

Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV

scientific article published on 01 October 2006

FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells

scientific article published on 01 September 2020

Flowcytometric quantitation of hepatitis B viral antigens in hepatocytes from regular and fine-needle biopsies

scientific article published on 27 February 2007

Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B.

scientific article published in September 2004

GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo

scientific article

Hepatitis E Virus Infects Neurons and Brains.

scientific article published on 11 February 2017

Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands

scientific article

Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis.

scientific article

IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes

scientific article published on 21 June 2016

Induction of regulatory T-cells and interleukin-10-producing cells in non-responders to pegylated interferon-alpha therapy for chronic hepatitis B

scientific article published on 01 January 2007

Inhibition of Calcineurin or IMP Dehydrogenase Exerts Moderate to Potent Antiviral Activity against Norovirus Replication

scientific article published on 14 August 2017

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

scientific article published on 01 March 2019

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

scientific article published on 23 September 2015

Multiple biopsy passes and the risk of complications of percutaneous liver biopsy

scientific article published on 23 August 2016

Multipotent mesenchymal stromal cells in liver cancer: implications for tumor biology and therapy.

scientific article published on 06 September 2014

Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development

scientific article published on 25 July 2016

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma

scientific article published on 03 January 2017

Prognostic value of intra-tumoral CD8 /FoxP3 lymphocyte ratio in patients with resected colorectal cancer liver metastasis

Protocol for the STRONG trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma, a phase I feasibility study

scientific article published on 15 October 2018

Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication

scientific article published on 22 October 2015

Short article: Management of ruptured hepatocellular carcinoma in a European tertiary care center

scientific article published on 25 April 2016

Surveillance for hepatocellular carcinoma is associated with increased survival: Results from a large cohort in the Netherlands

scientific article published on 19 June 2015

T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

scientific article published on January 2013

To target or not to target viral antigens in HBV related HCC?

scientific article published on 21 February 2015

Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors.

scientific article published on 19 March 2015

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