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List of works by Alan G Olivero

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma

scientific article

Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

scientific article

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

scientific article published on 26 June 2019

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and ro

scientific article published on 3 June 2013

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.

scientific article published on 16 February 2016

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer ⬇️

scientific article published on October 7, 2011

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform

scientific article

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

scientific article published on 12 March 2010

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform ⬇️

scientific article published on October 21, 2011

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase ⬇️

scientific article published on May 13, 2011

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase ⬇️

scientific article published on August 19, 2010

Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier

scientific article

The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.

scientific article published on 11 September 2012

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