List of works - Harvey Wong

A reversed sulfonamide series of selective RORc inverse agonists

scientific article

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) i

scientific article published on 23 June 2015

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

scientific article

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

scientific article

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

scientific article

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

scientific article published on 28 May 2015

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

scientific article published on 3 August 2016

Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism

scientific article

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists

scientific article published on 14 August 2015

Identification of tertiary sulfonamides as RORc inverse agonists

scientific article published on 21 March 2014

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.

scientific article published on 4 December 2014

N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists

scientific article

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold

scientific article

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834

scientific article

Presentation, management and outcomes of thrombosis for children with cardiomyopathy

scientific article

Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: correlation with drug exposure and anxiolytic efficacy

scientific article published in April 2003

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

scientific article

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc

scientific article

List of works by Harvey Wong

A reversed sulfonamide series of selective RORc inverse agonists

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) i

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism

Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists

Identification of tertiary sulfonamides as RORc inverse agonists

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.

N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834

Presentation, management and outcomes of thrombosis for children with cardiomyopathy

Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: correlation with drug exposure and anxiolytic efficacy

Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc