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List of works by Aesop Cho

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity ⬇️

scientific article published on December 13, 2011

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease ⬇️

scientific article published on February 2012

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

scientific article published on 20 February 2017

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

scientific article

Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.

scientific article published on 13 January 2014

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.

scientific article published on 13 January 2014

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

scientific article published on 01 January 2004

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

scientific article published in May 2004

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease ⬇️

scientific article published on May 3, 2011

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

scholarly article by Joy Y Feng et al published August 2018 in Antimicrobial Agents and Chemotherapy

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

scientific article published on 18 April 2006

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

scientific article

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors

scientific article published on 22 May 2014

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives

scientific article published in October 2004

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization

scientific article published on 27 February 2007

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

scientific article published in October 2004

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).

scientific article

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

scientific article

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

scientific article published on 8 March 2012

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

scientific article

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors

scientific article published on 20 April 2012

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors

scientific article

Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase

scientific article

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